Isomerases (EC 5.) and regulators superfamilies

1.13.01. D-glucuronyl C5-epimerase (1 family) PF06662 (Pfam)
1.13.02. Thioredoxin superfamily (9 families)
1.13.03. Peptidyl-prolyl cis-trans isomerase, FKBP-type (2 families) PF00254 (Pfam)
1.13.04. Cyclophilin type peptidyl-prolyl cis-trans isomerase (1 family) PF00160 (Pfam)
1.13.05. Peptidyl-prolyl cis-trans isomerase D (1 family) PF13145 (Pfam)
1.13.06. C-8 sterol isomerase family (1 family) PF04622 (Pfam)

Isomerases (EC 5.) and regulators (56 proteins)

Family Protein Name Protein ID Species Localization Topology TM Segment (helix) Hydrophobic Thickness (Å) Tilt Angle (°) ΔGfold (kcal/mol) ΔGtransf (kcal/mol)
1.13.01.01. D-glucuronyl C5-epimerase GLCE_HUMAN Homo sapiens Golgi memb. In 10-31 (10-35) 31.2 ± 3.4 2 ± 2 -16.0 -21.1
1.13.01.01. Uncharacterized protein MJ1128 Y1128_METJA Methanococcus jannaschii Archaebacterial memb. Und 2-27 (2-30) 34.8 ± 3.6 28 ± 0 -22.2 -32.8
1.13.02.01. Protein disulfide-isomerase 5-4 PDI54_ARATH Arabidopsis thaliana ER memb. Out 439-463 (434-468) 31.2 ± 3.6 30 ± 0 -8.6 -18.1
1.13.02.01. Protein disulfide-isomerase 5-2 PDI52_ARATH Arabidopsis thaliana ER memb. Out 378-399 (376-399) 30.4 ± 3.2 11 ± 10 -12.7 -21.4
1.13.02.01. Protein disulfide-isomerase 5-3 PDI53_ARATH Arabidopsis thaliana ER memb. Out 442-467 (439-471) 30.4 ± 3.6 42 ± 2 -7.6 -18.2
1.13.02.02. Thioredoxin domain-containing protein 11 TXD11_HUMAN Homo sapiens ER memb. In 63-84 (63-88) 31.0 ± 3.2 21 ± 12 -13.1 -16.3
1.13.02.02. Thioredoxin domain-containing protein 15 TXD15_HUMAN Homo sapiens ER memb. Out 322-344 (322-347) 33.4 ± 2.6 23 ± 9 -17.8 -25.7
1.13.02.02. Uncharacterized protein Q86HI2_DICDI Dictyostelium discoideum Membrane Out 265-290 (260-293) 28.4 ± 1.0 3 ± 1 -10.4 -26.9
1.13.02.02. Uncharacterized protein Q54BW3_DICDI Dictyostelium discoideum Membrane Out 389-411 (388-415) 32.2 ± 3.1 7 ± 9 -15.7 -22.1
1.13.02.02. Uncharacterized protein Q869Q9_DICDI Dictyostelium discoideum Membrane Out 292-316 (289-319) 30.8 ± 2.4 30 ± 0 -21.0 -27.7
1.13.02.02. ER-retained PMA1-suppressing protein 1 EPS1_YEAST Saccharomyces cerevisiae ER memb. Out 652-672 (652-684) 30.4 ± 2.0 13 ± 0 -14.0 -20.2
1.13.02.03. Thioredoxin-related transmembrane protein 1 TMX1_HUMAN Homo sapiens ER memb. Out 181-203 (180-203) 29.6 ± 1.8 0 ± 0 -16.0 -34.3
1.13.02.03. Thioredoxin-related transmembrane protein 2 TMX2_HUMAN Homo sapiens ER memb. In 108-128 (108-128) 30.0 ± 1.6 15 ± 1 -9.0 -17.6
1.13.02.03. Protein disulfide-isomerase TMX3 TMX3_HUMAN Homo sapiens ER memb. Out 375-396 (375-401) 32.0 ± 2.7 10 ± 12 -8.1 -19.5
1.13.02.03. Thioredoxin-related transmembrane protein 4 TMX4_HUMAN Homo sapiens ER memb. Out 186-210 (184-212) 35.6 ± 2.4 0 ± 1 -23.2 -49.3
1.13.02.04. Thiol:disulfide interchange protein DsbE DSBE_ECOLI Escherichia coli Gram-neg. inner In 4-24 (4-29) 31.4 ± 1.7 8 ± 1 -19.3 -26.5
1.13.02.05. 5'-adenylylsulfate reductase-like 4 APRL4_ARATH Arabidopsis thaliana ER memb. Out 215-241 (212-249) 30.8 ± 2.2 40 ± 0 -15.4 -27.3
1.13.02.05. 5'-adenylylsulfate reductase-like 5 APRL5_ARATH Arabidopsis thaliana ER memb. Out 201-223 (201-227) 33.4 ± 2.7 26 ± 6 -15.4 -25.1
1.13.02.05. 5'-adenylylsulfate reductase-like 6 APRL6_ARATH Arabidopsis thaliana ER memb. Out 205-233 (200-234) 38.0 ± 8.2 22 ± 2 -9.2 -25.0
1.13.02.05. 5'-adenylylsulfate reductase-like 7 APRL7_ARATH Arabidopsis thaliana ER memb. Out 196-218 (196-221) 33.6 ± 3.3 21 ± 21 -14.2 -23.1
1.13.02.06. Pheromone-regulated membrane protein 4 PRM4_YEAST Saccharomyces cerevisiae ER memb. In 17-39 (12-42) 33.6 ± 2.1 2 ± 4 -14.7 -23.4
1.13.02.07. Failed axon connections homolog FAXC_HUMAN Homo sapiens Nucleus memb. Und 62-87 (59-91) 33.2 ± 2.8 0 ± 2 -10.1 -28.0
1.13.02.07. Prostaglandin E synthase 2 PGES2_HUMAN Homo sapiens Golgi memb. Out 55-75 (55-82) 22.8 ± 4.4 0 ± 0 -7.7 -20.4
1.13.02.07. Ganglioside-induced differentiation-associated protein 1 GDAP1_HUMAN Homo sapiens Mito. outer memb. Und 317-340 (317-344) 26.0 ± 4.0 0 ± 0 -12.9 -24.7
1.13.02.07. Glutathione S-transferase family protein Q9FHX0_ARATH Arabidopsis thaliana Mito. memb. Und 52-70 (50-81) 28.2 ± 2.8 1 ± 1 -7.2 -12.8
1.13.02.07. Uncharacterized protein Q55BQ6_DICDI Dictyostelium discoideum Membrane Und 15-35 (15-36) 29.2 ± 2.2 10 ± 4 -8.8 -20.7
1.13.02.07. Monothiol glutaredoxin-6 GLRX6_YEAST Saccharomyces cerevisiae ER memb. Und 11-32 (9-37) 31.4 ± 3.4 9 ± 8 -16.6 -22.7
1.13.02.07. Monothiol glutaredoxin-7 GLRX7_YEAST Saccharomyces cerevisiae Golgi memb. Und 9-28 (7-33) 30.2 ± 3.0 2 ± 3 -9.3 -22.1
1.13.02.08. Chloride intracellular channel protein 1 CLIC1_HUMAN Homo sapiens Nucleus inner memb. Out 26-47 (26-51) 30.2 ± 1.7 6 ± 2 -0.4 -15.9
1.13.02.08. Chloride intracellular channel protein 3 CLIC3_HUMAN Homo sapiens Nucleus inner memb. Out 24-45 (24-48) 30.8 ± 2.6 3 ± 1 -2.5 -19.8
1.13.02.08. Chloride intracellular channel protein 4 CLIC4_HUMAN Homo sapiens Nucleus inner memb. Out 37-58 (37-62) 30.8 ± 3.0 5 ± 8 -3.8 -18.9
1.13.02.08. Chloride intracellular channel protein 5 CLIC5_HUMAN Homo sapiens Nucleus inner memb. Out 193-214 (193-218) 30.0 ± 1.3 5 ± 3 -2.2 -17.2
1.13.02.08. Chloride intracellular channel protein 6 CLIC6_HUMAN Homo sapiens Nucleus inner memb. Out 489-510 (489-514) 30.0 ± 1.3 5 ± 1 -2.4 -17.3
1.13.02.09. Sucrase/ferredoxin-like protein F4IWK4_ARATH Arabidopsis thaliana Membrane Und 352-374 (352-378) 25.6 ± 1.6 0 ± 0 -15.2 -27.1
1.13.02.09. Sucrase-like protein Q8LFZ9_ARATH Arabidopsis thaliana Membrane Und 419-439 (416-442) 28.4 ± 1.8 0 ± 0 -13.9 -28.8
1.13.02.09. AT5g40510/MNF13_30 Q8VYI8_ARATH Arabidopsis thaliana Membrane Und 308-330 (306-332) 30.4 ± 1.2 0 ± 0 -19.6 -38.3
1.13.02.09. At5g55900 Q9FG75_ARATH Arabidopsis thaliana Membrane Und 388-409 (385-412) 27.6 ± 1.6 2 ± 2 -12.7 -24.3
1.13.03.01. Peptidyl-prolyl cis-trans isomerase FKBP11 FKB11_HUMAN Homo sapiens ER memb. In 156-177 (156-181) 31.8 ± 2.6 18 ± 5 -11.1 -20.6
1.13.03.01. Peptidyl-prolyl cis-trans isomerase FKBP17-2, chloroplastic FK172_ARATH Arabidopsis thaliana Thyl. memb. Und 72- 97 (68-102) 32.0 ± 3.0 29 ± 20 -10.0 -16.0
1.13.03.01. Peptidyl-prolyl cis-trans isomerase FKBP17-3, chloroplastic FK173_ARATH Arabidopsis thaliana Thyl. memb. Und 64-85 (59-88) 32.0 ± 2.8 1 ± 7 -8.8 -16.0
1.13.03.01. Photosynthetic NDH subunit of lumenal location 4, chloroplastic PNSL4_ARATH Arabidopsis thaliana Thyl. memb. Und 47-69 (41-75) 33.0 ± 2.5 7 ± 2 -3.7 -15.6
1.13.03.01. FK506-binding protein 3 FKBP3_DICDI Dictyostelium discoideum ER memb. In 144-169 (144-171) 34.4 ± 4.8 30 ± 0 -14.7 -26.5
1.13.03.02. Peptidyl-prolyl cis-trans isomerase FKBP8 FKBP8_HUMAN Homo sapiens Mito. outer memb. In 387-409 (385-411) 33.2 ± 3.3 3 ± 2 -14.0 -17.1
1.13.03.02. Peptidyl-prolyl cis-trans isomerase PASTICCINO1 PAS1_ARATH Arabidopsis thaliana ER memb. In 610-634 (609-634) 30.0 ± 2.0 1 ± 2 -13.3 -34.1
1.13.03.02. Outer envelope protein 61, chloroplastic OEP61_ARATH Arabidopsis thaliana Chlor. outer memb. In 526-549 (516-549) 31.2 ± 3.6 26 ± 22 -18.9 -25.3
1.13.03.02. Peptidyl-prolyl cis-trans isomerase FKBP42 FKB42_ARATH Arabidopsis thaliana Plasma memb. In 336-357 (331-361) 29.2 ± 3.6 30 ± 0 -9.2 -16.9
1.13.03.02. Uncharacterized protein Q54MN4_DICDI Dictyostelium discoideum Membrane Und 82-102 (81-105) 28.0 ± 2.2 0 ± 0 -12.8 -33.7
1.13.04.01. Peptidyl-prolyl cis-trans isomerase CYP21-4 CP21D_ARATH Arabidopsis thaliana Golgi memb. In 22-44 (19-51) 33.4 ± 3.9 1 ± 5 -16.9 -20.7
1.13.04.01. Peptidyl-prolyl cis-trans isomerase CYP26-1 CP26A_ARATH Arabidopsis thaliana Membrane Out 211-231 (206-231) 29.0 ± 2.9 18 ± 0 -13.9 -18.7
1.13.04.01. Peptidyl-prolyl cis-trans isomerase CYP21-3, mitochondrial CP21C_ARATH Arabidopsis thaliana Mito. memb. In 23-45 (19-46) 34.8 ± 4.0 12 ± 10 -22.6 -25.4
1.13.04.01. Peptidyl-prolyl cis-trans isomerase CYP8 CYP8_YEAST Saccharomyces cerevisiae Vacuole memb. Out 271-291 (271-294) 30.4 ± 2.6 10 ± 14 -13.1 -21.8
1.13.04.01. Peptidyl-prolyl cis-trans isomerase CPR4 CYPR_YEAST Saccharomyces cerevisiae ER memb. Out 286-306 (284-307) 29.0 ± 2.4 4 ± 3 -7.5 -15.6
1.13.05.01. Peptidyl-prolyl cis-trans isomerase D PPID_ECOLI Escherichia coli Gram-neg. inner In 8-29 (8-34) 29.2 ± 3.4 0 ± 3 -13.5 -37.5
1.13.06.01. Sigma non-opioid intracellular receptor 1 SGMR1_HUMAN Homo sapiens ER memb. Und 8-30 (4-33) 34.4 ± 2.2 3 ± 2 -17.4 -50.0
1.13.06.01. C-8 sterol isomerase Q5Q0I8_ARATH Arabidopsis thaliana ER memb. Und 144-169 (139-171) 30.8 ± 2.8 34 ± 28 -15.9 -24.5
1.13.06.01. C-8 sterol isomerase ERG2_YEAST Saccharomyces cerevisiae ER memb. Und 3-25 (3-25) 29.2 ± 2.2 5 ± 3 -9.7 -27.9