Lyases (EC 4.) and regulators superfamilies

1.12.01. Carbonic anhydrase (1 family) PF00194 (Pfam)
1.12.02. NAD-dependent epimerase/dehydratase (2 families) PF16363 (Pfam)
1.12.03. tRNA wybutosine-synthase (1 family)
1.12.04. 2-hydroxyglutaryl-CoA dehydratase (1 family) PF06050 (Pfam)
1.12.05. Pyridoxal phosphate-dependent decarboxylase (1 family) PF00282 (Pfam)
1.12.06. Phosphatidylserine decarboxylase (1 family) PF02666 (Pfam)
1.12.07. Pectate lyase (2 families) PF00544 (Pfam)
1.12.08. Chromophore lyase (1 family) PF06206 (Pfam)

Lyases (EC 4.) and regulators (37 proteins)

Family Protein Name Protein ID Species Localization Topology TM Segment (helix) Hydrophobic Thickness (Å) Tilt Angle (°) ΔGfold (kcal/mol) ΔGtransf (kcal/mol)
1.12.01.01. Carbonic anhydrase 12 CAH12_HUMAN Homo sapiens Plasma memb. Out 299-331 (296-333) 42.8 ± 0.8 0 ± 0 -23.7 -62.0
1.12.01.01. Carbonic anhydrase 14 CAH14_HUMAN Homo sapiens Plasma memb. Out 287-312 (287-324) 31.2 ± 1.6 0 ± 2 -19.1 -43.0
1.12.01.01. Carbonic anhydrase 9 CAH9_HUMAN Homo sapiens Plasma memb. Out 414-435 (414-440) 30.4 ± 2.4 0 ± 1 -18.1 -36.7
1.12.01.01. Carbonic anhydrase 4 CAH4_HUMAN Homo sapiens Plasma memb. Out 290-311 (290-311) 32.8 ± 2.2 5 ± 4 -7.8 -19.6
1.12.01.01. Alpha carbonic anhydrase 6 ATCA6_ARATH Arabidopsis thaliana Plasma memb. Out 233-259 (233-260) 34.8 ± 2.6 30 ± 2 -12.9 -24.3
1.12.02.01. Probable UDP-arabinose 4-epimerase 3 ARAE3_ARATH Arabidopsis thaliana Golgi memb. In 31-52 (24-52) 31.6 ± 3.4 8 ± 10 -12.0 -20.3
1.12.02.01. Putative UDP-arabinose 4-epimerase 4 ARAE4_ARATH Arabidopsis thaliana Golgi memb. In 56-78 (56-79) 32.4 ± 2.7 0 ± 0 -14.9 -23.9
1.12.02.01. Putative UDP-arabinose 4-epimerase 2 ARAE2_ARATH Arabidopsis thaliana Golgi memb. In 32-51 (30-53) 29.6 ± 2.8 7 ± 5 -11.7 -18.0
1.12.02.01. UDP-arabinose 4-epimerase 1 ARAE1_ARATH Arabidopsis thaliana Golgi memb. In 33-54 (33-54) 29.4 ± 2.4 15 ± 14 -9.6 -16.3
1.12.02.01. UDP-glucuronic acid decarboxylase 1 B3H4I6_ARATH Arabidopsis thaliana Golgi memb. In 45-67 (45-72) 30.8 ± 2.2 2 ± 2 -12.2 -40.4
1.12.02.01. AT2G47650 protein C0Z2I3_ARATH Arabidopsis thaliana Golgi memb. In 40-62 (40-65) 29.6 ± 1.2 0 ± 0 -16.8 -39.8
1.12.02.02. UDP-glucuronic acid decarboxylase 1 UXS1_HUMAN Homo sapiens Golgi memb. In 17-38 (12-42) 30.4 ± 1.6 0 ± 2 -13.7 -30.4
1.12.02.02. UDP-glucuronic acid decarboxylase 1 UXS1_ARATH Arabidopsis thaliana Golgi memb. In 45-67 (45-72) 30.8 ± 2.2 2 ± 2 -12.2 -40.4
1.12.02.02. UDP-glucuronic acid decarboxylase 2 UXS2_ARATH Arabidopsis thaliana Golgi memb. In 41-62 (40-64) 28.4 ± 2.8 3 ± 2 -16.0 -32.9
1.12.02.02. UDP-glucuronic acid decarboxylase 4 UXS4_ARATH Arabidopsis thaliana Golgi memb. In 40-62 (40-65) 34.2 ± 3.2 15 ± 13 -16.8 -23.4
1.12.03.01. S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1_HUMAN Homo sapiens Membrane Out 22-44 (21-45) 26.0 ± 2.4 1 ± 1 -9.1 -22.6
1.12.03.01. S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B_HUMAN Homo sapiens Membrane Out 22-44 (21-45) 30.4 ± 2.2 1 ± 0 -11.0 -26.2
1.12.03.01. S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1_ARATH Arabidopsis thaliana Membrane Out 7-28 (3-35) 33.0 ± 4.0 6 ± 6 -11.0 -17.0
1.12.03.01. S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1_YEAST Saccharomyces cerevisiae ER memb. Out 3-23 (2-23) 26.0 ± 1.2 0 ± 2 -7.0 -27.2
1.12.04.01. Uncharacterized protein MJ0007 Y007_METJA Methanococcus jannaschii Archaebacterial memb. Und 30-50 (26-50) 30.2 ± 3.9 11 ± 11 -4.5 -14.1
1.12.05.01. Sphingosine-1-phosphate lyase 1 SGPL1_HUMAN Homo sapiens ER memb. Out 39-60 (39-61) 27.2 ± 1.7 27 ± 1 -10.0 -18.5
1.12.05.01. Sphingosine-1-phosphate lyase SGPL_ARATH Arabidopsis thaliana ER memb. Out 27-48 (27-56) 31.4 ± 2.8 5 ± 16 -11.5 -20.4
1.12.05.01. Sphingosine-1-phosphate lyase SGPL_DICDI Dictyostelium discoideum ER memb. Out 12-33 (11-37) 30.8 ± 2.8 7 ± 0 -11.8 -14.6
1.12.06.01. Phosphatidylserine decarboxylase proenzyme 1, mitochondrial PSD1_ARATH Arabidopsis thaliana Mito. inner memb. Und 71- 90 (69-104) 27.2 ± 1.8 2 ± 1 -11.8 -33.1
1.12.06.01. Phosphatidylserine decarboxylase C7FZZ8_DICDI Dictyostelium discoideum Membrane Und 91-109 (91-112) 29.0 ± 2.4 24 ± 9 -8.8 -21.2
1.12.06.01. Phosphatidylserine decarboxylase proenzyme 1, mitochondrial PSD1_YEAST Saccharomyces cerevisiae Mito. inner memb. Und 76-97 (70-98) 24.4 ± 2.4 0 ± 0 -12.0 -32.6
1.12.06.01. Phosphatidylserine decarboxylase proenzyme PSD_METJA Methanococcus jannaschii Archaebacterial memb. Und 3-23 (3-24) 24.0 ± 0.8 0 ± 0 -12.1 -27.7
1.12.07.01. Probable pectate lyase 12 PLY12_ARATH Arabidopsis thaliana Membrane Out 456-476 (452-478) 31.2 ± 2.7 5 ± 5 -11.3 -19.0
1.12.07.01. Probable pectate lyase 13 PLY13_ARATH Arabidopsis thaliana Plasma memb. Out 479-501 (478-501) 32.8 ± 2.5 2 ± 1 -10.9 -21.2
1.12.07.02. Uncharacterized protein Q551H1_DICDI Dictyostelium discoideum Membrane Und 517-545 (517-549) 36.8 ± 4.4 0 ± 0 -28.2 -63.3
1.12.07.02. Uncharacterized protein Q54WL1_DICDI Dictyostelium discoideum Membrane Und 501-526 (498-529) 30.8 ± 1.4 0 ± 0 -18.4 -46.6
1.12.07.02. Uncharacterized protein Q54L18_DICDI Dictyostelium discoideum Membrane Und 530-558 (530-561) 32.0 ± 2.2 0 ± 0 -19.7 -40.3
1.12.07.02. Uncharacterized protein Q54KS1_DICDI Dictyostelium discoideum Membrane Und 491-520 (491-525) 39.2 ± 5.0 29 ± 19 -27.1 -32.7
1.12.07.02. Uncharacterized protein Q54SB0_DICDI Dictyostelium discoideum Membrane Und 576-601 (576-607) 29.6 ± 7.0 49 ± 2 -25.2 -26.9
1.12.07.02. Uncharacterized protein Q54YB0_DICDI Dictyostelium discoideum Membrane Und 543-570 (540-574) 32.8 ± 3.4 1 ± 0 -21.0 -41.8
1.12.07.02. Uncharacterized protein Q54YC0_DICDI Dictyostelium discoideum Membrane Und 536-558 (533-561) 33.2 ± 2.0 4 ± 3 -14.5 -32.1
1.12.08.01. Chromophore lyase CRL, chloroplastic CRL_ARATH Arabidopsis thaliana Chlor. outer memb. Out 21-43 (15-46) 30.2 ± 4.0 20 ± 17 -5.8 -20.4