Hydrolases (EC 3.) and regulators superfamilies

1.11.01. Peptidase clan AA (CL0129) (2 families)
1.11.02. Peptidase clan CD (CL0093) (3 families)
1.11.03. Peptidase clan MA (CL0126) (11 family)
1.11.04. Peptidase clan MH/MC/MF (CL0035) (6 families)
1.11.05. Peptidase clan MO (1 family) PF04225 (Pfam)
1.11.06. Peptidase clan PA (CL0124) (4 families)
1.11.07. Peptidase clan SB (2 families)
1.11.08. Peptidase clan SF (CL0299) (2 families)
1.11.09. Dipeptidylpeptidase IV (1 family) PF00930 (Pfam)
1.11.10. Peptidase C19 (1 family)
1.11.11. Peptidase S49 family (1 family) PF01343 (Pfam)
1.11.12. Signal peptidase complex subunit 3 (1 family) PF04573 (Pfam)
1.11.13. Serine dehydrogenase proteinase (1 family) PF01972 (Pfam)
1.11.14. Mitochondrial inner membrane i-AAA protease subunits (1 family)
1.11.15. Nicastrin (2 families) PF05450 (Pfam)
1.11.16. Metalloprotease TIKI (1 family)
1.11.17. Putative zinc metallopeptidase (1 family)
1.11.18. Lipase, GDSL (1 family) PF00657 (Pfam)
1.11.19. Patatin-like phospholipase domain-containing proteins (3 families) PF01734 (Pfam)
1.11.20. AB hydrolase (19 family)
1.11.21. Phospholipase D (1 family) PF00614 (Pfam)
1.11.22. Neutral/alkaline nonlysosomal ceramidase (1 family) PF04734 (Pfam)
1.11.23. NAPE-PLD family (1 family)
1.11.24. Regulatory protein phosphatase (1 family) PF00481 (Pfam)
1.11.25. Histidine phosphatase (2 families) PF00300 (Pfam)
1.11.26. Inositol monophosphatase (1 family) PF00459 (Pfam)
1.11.27. Glycoside hydrolase (beta-propeller) (1 family) PF04616 (Pfam)
1.11.28. Nucleotide pyrophosphatase/phosphodiesterase (1 family) PF01663 (Pfam)
1.11.29. Glycoside hydrolase, family 28 (1 family) PF00295 (Pfam)
1.11.30. CDP-diacylglycerol pyrophosphatase. (1 family) PF02611 (Pfam)
1.11.31. Alkaline phosphatase (2 families) PF00245 (Pfam)
1.11.32. GDA1/CD39 nucleoside phosphatase (1 family) PF01150 (Pfam)
1.11.33. Acid phosphatase family (1 family) PF03767 (Pfam)
1.11.34. Endonuclease/Exonuclease/phosphatase family (1 family) PF03372 (Pfam)
1.11.35. Glycerophosphoryl diester phosphodiesterase (2 families) PF03009 (Pfam)
1.11.36. Mitochondrial sphingomyelin phosphodiesterase (1 family) PF14724 (Pfam)
1.11.37. Phosphatidylglycerophosphatase C (1 family)
1.11.38. N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (1 family)
1.11.39. Tim barrel glycosyl hydrolase superfamily (CL0058) (8 families)
1.11.40. Glycoside hydrolase/deacetylase (CL0158) (1 family)
1.11.41. Six-hairpin glycosidase (CL0059) (3 families)
1.11.42. Lysozyme-like hydrolases (CL0037) (1 family)
1.11.43. ADP-ribosyl cyclase (CD38/157) (1 family) PF02267 (Pfam)
1.11.44. Apyrase (1 family) PF06079 (Pfam)
1.11.45. Probable endonuclease (1 family)
1.11.46. Ribonuclease MRP subunit (1 family)
1.11.47. Pectinesterase (1 family) PF01095 (Pfam)
1.11.48. Strictosidine synthase (1 family) PF03088 (Pfam)
1.11.49. Amidase (1 family) PF01425 (Pfam)
1.11.50. Calcineurin-like phosphoesterase (4 families) PF00149 (Pfam)
1.11.51. Nudix hydrolase (1 family) PF00293 (Pfam)
1.11.52. Adenosine and AMP deaminases (1 family) PF00962 (Pfam)
1.11.53. Complement regulators (3 families)
1.11.54. MANSC domain-containing proteins (1 family) PF07502 (Pfam)
1.11.55. Proteinase BPTI/Kunitz inhibitor domain-containing protein (1 family) PF00014 (Pfam)
1.11.56. Proteinase inhibitor latexin (1 family) PF06907 (Pfam)
1.11.57. Apoptosis regulator, Bcl2-like (3 families)
1.11.58. Cathepsin inhibitor domain protein (1 family)
1.11.59. Protein RCAS1 (1 family)
1.11.60. Acetylcholinesterase anchor (1 family)
1.11.61. Tissue factor/coagulation factor III (1 family) PF01108 (Pfam)
1.11.63. Cysteine-rich secretory protein family (1 family) PF00188 (Pfam)
1.11.64. Lipopolysaccharide assembly proteins (1 family)
1.11.65. Probable glycoside hydrolase (2 families)

Hydrolases (EC 3.) and regulators (415 proteins)

Family Protein Name Protein ID Species Localization Topology TM Segment (helix) Hydrophobic Thickness (Å) Tilt Angle (°) ΔGfold (kcal/mol) ΔGtransf (kcal/mol)
1.11.01.01. Beta-secretase 1 BACE1_HUMAN Homo sapiens Plasma memb. Out 450-479 (450-487) 34.4 ± 0.0 44 ± 0 -20.8 -27.3
1.11.01.01. Beta-secretase 2 BACE2_HUMAN Homo sapiens Plasma memb. Out 465-494 (465-499) 34.0 ± 3.8 45 ± 4 -23.8 -29.3
1.11.01.01. Aspartyl protease family protein Q9SN13_ARATH Arabidopsis thaliana Membrane Out 583-605 (583-611) 30.8 ± 4.2 30 ± 9 -18.4 -16.7
1.11.01.01. Aspartyl protease family protein F4K4L3_ARATH Arabidopsis thaliana Membrane Out 575-600 (570-607) 30.8 ± 3.8 35 ± 4 -15.4 -18.5
1.11.01.01. Uncharacterized protein Q54WT3_DICDI Dictyostelium discoideum Membrane Out 682-708 (680-710) 40.0 ± 3.2 1 ± 1 -22.4 -26.1
1.11.01.02. Retroviral-like aspartic protease 1 APRV1_HUMAN Homo sapiens ER memb. In 56-77 (55-77) 24.8 ± 1.2 0 ± 2 -10.5 -22.8
1.11.02.01. GPI-anchor transamidase GPI8_HUMAN Homo sapiens ER memb. Out 366-386 (366-386) 30.4 ± 2.4 20 ± 5 -11.1 -21.3
1.11.02.01. Peptidase C13-like protein Q8GYI6_ARATH Arabidopsis thaliana ER memb. Out 366-386 (365-387) 29.8 ± 3.7 1 ± 14 -12.1 -17.5
1.11.02.01. Uncharacterized protein Q54N74_DICDI Dictyostelium discoideum ER memb. Out 402-422 (402-427) 29.6 ± 4.0 0 ± 0 -13.4 -20.7
1.11.02.01. GPI-anchor transamidase GPI8_YEAST Saccharomyces cerevisiae ER memb. Out 378-398 (375-398) 30.8 ± 2.5 4 ± 3 -14.9 -23.4
1.11.02.02. Inactive ubiquitin thioesterase FAM105A F105A_HUMAN Homo sapiens Plasma memb. In 40-63 (38-65) 34.0 ± 2.0 10 ± 8 -16.0 -24.0
1.11.02.03. Gamma-glutamyl hydrolase B GGHB_DICDI Dictyostelium discoideum Plasma memb. Out 326-347 (326-347) 32.4 ± 1.4 2 ± 0 -14.0 -25.3
1.11.03.01. Glutamyl aminopeptidase AMPE_HUMAN Homo sapiens Plasma memb. In 14-40 (7-42) 30.0 ± 2.0 0 ± 2 -16.2 -34.8
1.11.03.01. Aminopeptidase N AMPN_HUMAN Homo sapiens Plasma memb. In 10-33 (6-39) 32.8 ± 1.6 1 ± 1 -18.0 -38.2
1.11.03.01. Aminopeptidase Q AMPQ_HUMAN Homo sapiens Vesicle memb. In 14-36 (6-37) 42.0 ± 4.2 0 ± 5 -25.9 -38.7
1.11.03.01. Endoplasmic reticulum aminopeptidase 1 ERAP1_HUMAN Homo sapiens ER memb. In 6-27 (5-28) 30.8 ± 2.8 16 ± 14 -11.9 -19.0
1.11.03.01. Leucyl-cystinyl aminopeptidase LCAP_HUMAN Homo sapiens Plasma memb. In 108-131 (106-131) 31.6 ± 1.4 2 ± 0 -18.6 -38.1
1.11.03.01. Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE_HUMAN Homo sapiens Plasma memb. In 34-65 (34-65) 38.4 ± 3.0 4 ± 1 -24.6 -49.6
1.11.03.01. Uncharacterized protein Q557I4_DICDI Dictyostelium discoideum Membrane In 58-80 (55-83) 34.4 ± 3.4 8 ± 7 -18.9 -27.9
1.11.03.02. Angiotensin-converting enzyme 2 ACE2_HUMAN Homo sapiens Plasma memb. Out 738-765 (738-770) 35.2 ± 5.8 34 ± 11 -26.4 -30.9
1.11.03.02. Angiotensin-converting enzyme ACE_HUMAN Homo sapiens Plasma memb. Out 1256-1275 (1251-1277) 29.8 ± 3.0 8 ± 4 -18.2 -21.4
1.11.03.02. Collectrin TMM27_HUMAN Homo sapiens Plasma memb. Out 140-167 (139-171) 36.8 ± 4.6 23 ± 3 -29.5 -31.7
1.11.03.03. Matrix metalloproteinase-14 MMP14_HUMAN Homo sapiens Plasma memb. Out 537-562 (536-565) 34.0 ± 4.0 30 ± 0 -27.9 -32.7
1.11.03.03. Matrix metalloproteinase-15 MMP15_HUMAN Homo sapiens Plasma memb. Out 621-646 (618-651) 35.2 ± 2.6 20 ± 10 -22.7 -28.6
1.11.03.03. Matrix metalloproteinase-16 MMP16_HUMAN Homo sapiens Plasma memb. Out 559-588 (558-590) 39.2 ± 4.2 30 ± 15 -22.5 -30.3
1.11.03.03. Matrix metalloproteinase-23 MMP23_HUMAN Homo sapiens Plasma memb. In 19-40 (16-40) 32.2 ± 2.6 15 ± 8 -14.0 -19.9
1.11.03.03. Matrix metalloproteinase-24 MMP24_HUMAN Homo sapiens Plasma memb. Out 601-626 (599-628) 34.4 ± 3.0 19 ± 2 -15.9 -22.7
1.11.03.04. Meprin A subunit alpha MEP1A_HUMAN Homo sapiens Plasma memb. Out 718-740 (717-742) 32.4 ± 2.0 0 ± 2 -12.8 -41.3
1.11.03.04. Meprin A subunit beta MEP1B_HUMAN Homo sapiens Plasma memb. Out 655-677 (652-685) 33.2 ± 2.6 0 ± 0 -23.4 -48.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 10 ADA10_HUMAN Homo sapiens Plasma memb. Out 671-699 (670-702) 38.0 ± 6.4 30 ± 0 -23.3 -25.9
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 11 ADA11_HUMAN Homo sapiens Plasma memb. Out 732-758 (730-764) 34.4 ± 2.8 0 ± 4 -12.9 -41.5
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 12 ADA12_HUMAN Homo sapiens Plasma memb. Out 707-730 (705-732) 34.4 ± 2.8 4 ± 3 -19.5 -22.1
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 15 ADA15_HUMAN Homo sapiens Plasma memb. Out 692-717 (690-719) 34.4 ± 2.8 2 ± 1 -21.7 -42.5
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 17 ADA17_HUMAN Homo sapiens Plasma memb. Out 669-698 (669-698) 30.4 ± 2.2 1 ± 1 -10.7 -32.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 18 ADA18_HUMAN Homo sapiens Plasma memb. Out 687-709 (687-710) 27.2 ± 1.6 3 ± 2 -17.3 -42.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 19 ADA19_HUMAN Homo sapiens Plasma memb. Out 701-725 (701-726) 35.2 ± 1.4 17 ± 10 -20.4 -28.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 20 ADA20_HUMAN Homo sapiens Plasma memb. Out 691-715 (687-720) 36.0 ± 2.8 2 ± 9 -21.8 -27.0
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 21 ADA21_HUMAN Homo sapiens Plasma memb. Out 679-707 (675-711) 42.4 ± 4.8 2 ± 1 -16.0 -29.6
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 22 ADA22_HUMAN Homo sapiens Plasma memb. Out 732-760 (732-767) 36.0 ± 1.2 0 ± 2 -21.7 -51.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 23 ADA23_HUMAN Homo sapiens Plasma memb. Out 791-816 (788-822) 32.0 ± 1.8 40 ± 12 -14.1 -17.1
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 28 ADA28_HUMAN Homo sapiens Plasma memb. Out 661-689 (657-693) 37.6 ± 3.0 20 ± 1 -23.9 -30.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 29 ADA29_HUMAN Homo sapiens Plasma memb. Out 673-695 (668-701) 34.8 ± 2.2 4 ± 3 -23.0 -26.6
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 30 ADA30_HUMAN Homo sapiens Plasma memb. Out 687-711 (683-711) 36.8 ± 2.0 0 ± 1 -17.1 -55.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 32 ADA32_HUMAN Homo sapiens Plasma memb. Out 681-705 (680-705) 34.8 ± 2.0 10 ± 8 -19.6 -25.0
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 33 ADA33_HUMAN Homo sapiens Plasma memb. Out 699-725 (699-727) 34.4 ± 5.6 32 ± 2 -11.4 -21.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 2 ADAM2_HUMAN Homo sapiens Plasma memb. Out 687-711 (686-714) 31.6 ± 1.2 0 ± 0 -21.4 -44.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 7 ADAM7_HUMAN Homo sapiens Plasma memb. Out 665-692 (661-696) 40.0 ± 4.8 16 ± 13 -27.2 -34.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 8 ADAM8_HUMAN Homo sapiens Plasma memb. Out 653-681 (653-683) 35.6 ± 3.8 32 ± 0 -29.4 -33.7
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 9 ADAM9_HUMAN Homo sapiens Plasma memb. Out 693-719 (693-721) 34.4 ± 4.0 30 ± 23 -21.1 -31.5
1.11.03.06. Endothelin-converting enzyme 1 ECE1_HUMAN Homo sapiens Plasma memb. In 64-89 (64-95) 35.6 ± 1.4 1 ± 1 -21.2 -30.4
1.11.03.06. Endothelin-converting enzyme 2 ECE2_HUMAN Homo sapiens Golgi memb. In 176-201 (176-206) 33.6 ± 3.4 29 ± 4 -21.0 -20.7
1.11.03.06. Endothelin-converting enzyme-like 1 ECEL1_HUMAN Homo sapiens Plasma memb. In 60-85 (57-85) 36.4 ± 3.4 11 ± 3 -18.8 -22.7
1.11.03.06. Kell blood group glycoprotein KELL_HUMAN Homo sapiens Plasma memb. In 45-69 (41-70) 36.4 ± 3.0 16 ± 7 -18.6 -26.1
1.11.03.06. Membrane metallo-endopeptidase-like 1 MMEL1_HUMAN Homo sapiens Plasma memb. In 25-49 (25-51) 36.4 ± 2.6 8 ± 10 -20.6 -27.7
1.11.03.06. Neprilysin NEP_HUMAN Homo sapiens Plasma memb. In 26-51 (26-52) 35.2 ± 2.2 29 ± 6 -25.8 -28.6
1.11.03.06. Phosphate-regulating neutral endopeptidase PHEX_HUMAN Homo sapiens Plasma memb. In 18-40 (17-50) 33.6 ± 1.8 0 ± 1 -14.9 -44.7
1.11.03.07. Probable carboxypeptidase S-like 2 CBPS2_DICDI Dictyostelium discoideum Membrane In 24-52 (24-54) 28.8 ± 3.0 47 ± 0 -14.5 -23.7
1.11.03.07. Putative carboxypeptidase YOL153C CBPS2_YEAST Saccharomyces cerevisiae Membrane In 26-46 (23-49) 29.2 ± 3.7 1 ± 0 -12.7 -22.4
1.11.03.07. Carboxypeptidase S CBPS_YEAST Saccharomyces cerevisiae Vacuole memb. In 20-40 (14-41) 31.8 ± 2.9 1 ± 0 -14.5 -20.9
1.11.03.07. Uncharacterized protein YgeY YGEY_ECOLI Escherichia coli Gram-neg. inner Out 381-401 (378-402) 26.4 ± 2.4 7 ± 0 -7.4 -23.9
1.11.03.08. Uncharacterized peptidase YFR006W YFH6_YEAST Saccharomyces cerevisiae Membrane Out 5-25 (5-31) 32.8 ± 2.7 9 ± 8 -10.8 -20.3
1.11.03.09. MIFR-2 O75086_HUMAN Homo sapiens Plasma memb. In 19-40 (16-40) 32.2 ± 2.6 15 ± 8 -14.0 -19.9
1.11.03.10. GP63 Q6TU47_DICDI Dictyostelium discoideum Plasma memb. Out 660-682 (659-682) 33.4 ± 2.7 5 ± 3 -11.9 -21.7
1.11.03.10. Uncharacterized protein Q54LN5_DICDI Dictyostelium discoideum Plasma memb. Out 745-766 (744-771) 31.8 ± 2.9 4 ± 3 -12.5 -15.8
1.11.03.11. Uncharacterized protein Q54HN7_DICDI Dictyostelium discoideum Membrane Und 350-370 (348-372) 29.8 ± 2.8 5 ± 3 -7.9 -15.1
1.11.04.01. Carboxypeptidase D CBPD_HUMAN Homo sapiens Plasma memb. Out 1301-1325 (1297-1329) 34.0 ± 5.6 21 ± 11 -13.5 -18.8
1.11.04.02. Glutamate carboxypeptidase 2 FOLH1_HUMAN Homo sapiens Plasma memb. In 20-44 (18-49) 30.8 ± 2.0 2 ± 1 -16.7 -46.3
1.11.04.02. Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 NADL2_HUMAN Homo sapiens Plasma memb. In 122-146 (122-148) 34.8 ± 3.8 19 ± 7 -15.1 -23.1
1.11.04.02. N-acetylated-alpha-linked acidic dipeptidase 2 NALD2_HUMAN Homo sapiens Plasma memb. In 8-32 (2-32) 32.8 ± 1.4 0 ± 1 -18.2 -50.7
1.11.04.02. N-acetylated-alpha-linked acidic dipeptidase-like protein NALDL_HUMAN Homo sapiens Plasma memb. In 3-28 (2-28) 37.2 ± 3.8 1 ± 2 -12.1 -21.1
1.11.04.02. Transferrin receptor protein 1 TFR1_HUMAN Homo sapiens Plasma memb. In 66-90 (65-90) 28.4 ± 3.4 0 ± 0 -17.3 -35.4
1.11.04.02. Transferrin receptor protein 2 TFR2_HUMAN Homo sapiens Plasma memb. In 83-104 (83-105) 26.8 ± 1.6 0 ± 1 -17.6 -31.0
1.11.04.02. Probable glutamate carboxypeptidase 2 GCP2_ARATH Arabidopsis thaliana Plasma memb. In 23-42 (23-43) 29.8 ± 2.8 13 ± 6 -16.0 -22.5
1.11.04.02. Vacuolar protein sorting-associated protein 70 VPS70_YEAST Saccharomyces cerevisiae Plasma memb. In 85-106 (77-109) 33.2 ± 2.1 1 ± 10 -18.5 -16.2
1.11.04.02. Putative zinc metalloprotease TRE2 TRE2_YEAST Saccharomyces cerevisiae Plasma memb. In 123-146 (120-149) 32.0 ± 2.4 1 ± 0 -9.3 -29.0
1.11.04.02. Uncharacterized protein TRE1 TRE1_YEAST Saccharomyces cerevisiae Plasma memb. In 106-130 (105-130) 34.8 ± 2.2 10 ± 6 -10.4 -21.2
1.11.04.03. Glutaminyl-peptide cyclotransferase-like protein QPCTL_HUMAN Homo sapiens Golgi memb. In 35-56 (35-62) 30.2 ± 3.1 38 ± 4 -11.0 -18.3
1.11.04.04. Protease-associated domain-containing protein F4JGJ7_ARATH Arabidopsis thaliana Membrane Und 214-232 (214-232) 26.8 ± 0.7 19 ± 5 -5.5 -13.5
1.11.04.05. Putative carboxypeptidase D F4IA17_ARATH Arabidopsis thaliana Plasma memb. Out 384-405 (381-405) 27.6 ± 2.4 4 ± 2 -14.2 -38.9
1.11.04.05. F14O23.7 protein Q9M9H7_ARATH Arabidopsis thaliana Plasma memb. Out 453-474 (450-474) 27.6 ± 2.4 4 ± 2 -14.2 -38.9
1.11.04.05. Zn-dependent exopeptidases superfamily protein F4K1I4_ARATH Arabidopsis thaliana Plasma memb. Out 344-365 (340-369) 33.2 ± 2.9 5 ± 3 -15.7 -21.5
1.11.04.06. Uncharacterized protein YfbL YFBL_ECOLI Escherichia coli Gram-neg. inner Und 2-22 (2-23) 33.6 ± 1.7 12 ± 0 -19.3 -28.6
1.11.05.01. Murein DD-endopeptidase MepM YEBA_ECOLI Escherichia coli Gram-neg. inner In 21-40 (16-45) 29.6 ± 3.4 4 ± 7 -8.6 -18.3
1.11.05.01. Uncharacterized protein YtfB YTFB_ECOLI Escherichia coli Gram-neg. inner Und 30-50 (29-51) 30.0 ± 3.0 2 ± 2 -7.8 -16.5
1.11.06.01. Enteropeptidase ENTK_HUMAN Homo sapiens Plasma memb. In 17-41 (16-47) 37.2 ± 4.0 5 ± 5 -28.2 -28.9
1.11.06.01. Serine protease hepsin HEPS_HUMAN Homo sapiens Plasma memb. In 18-44 (14-46) 36.0 ± 2.8 27 ± 0 -17.6 -22.9
1.11.06.01. Prostasin PRSS8_HUMAN Homo sapiens Plasma memb. Out 316-340 (316-342) 34.4 ± 1.6 18 ± 16 -3.0 -23.3
1.11.06.01. Transmembrane protease serine 11A TM11A_HUMAN Homo sapiens Plasma memb. In 17-42 (17-48) 39.6 ± 3.2 2 ± 1 -25.2 -42.2
1.11.06.01. Transmembrane protease serine 11B TM11B_HUMAN Homo sapiens Plasma memb. In 12-43 (12-43) 38.8 ± 1.6 2 ± 2 -23.9 -59.7
1.11.06.01. Transmembrane protease serine 11D TM11D_HUMAN Homo sapiens Plasma memb. In 16-41 (16-43) 39.6 ± 1.8 0 ± 0 -27.8 -49.8
1.11.06.01. Transmembrane protease serine 11E TM11E_HUMAN Homo sapiens Plasma memb. In 16-41 (16-49) 34.4 ± 3.4 34 ± 3 -22.5 -24.8
1.11.06.01. Transmembrane protease serine 11F TM11F_HUMAN Homo sapiens Plasma memb. In 30-52 (25-57) 34.0 ± 1.6 3 ± 1 -21.8 -44.0
1.11.06.01. Transmembrane protease serine 2 TMPS2_HUMAN Homo sapiens Plasma memb. In 83-109 (79-112) 34.4 ± 4.2 29 ± 1 -18.5 -26.5
1.11.06.01. Transmembrane protease serine 3 TMPS3_HUMAN Homo sapiens ER memb. In 48-69 (48-74) 30.8 ± 4.8 37 ± 21 -22.3 -23.7
1.11.06.01. Transmembrane protease serine 4 TMPS4_HUMAN Homo sapiens Plasma memb. In 25-57 (25-59) 33.6 ± 3.6 48 ± 1 -21.8 -35.8
1.11.06.01. Transmembrane protease serine 5 TMPS5_HUMAN Homo sapiens Plasma memb. In 48-72 (43-72) 35.6 ± 2.4 22 ± 19 -8.7 -15.4
1.11.06.01. Transmembrane protease serine 6 TMPS6_HUMAN Homo sapiens Plasma memb. In 49-76 (41-78) 36.4 ± 4.2 19 ± 10 -24.2 -31.4
1.11.06.01. Transmembrane protease serine 7 TMPS7_HUMAN Homo sapiens Plasma memb. In 59-87 (59-91) 34.0 ± 3.8 32 ± 1 -27.7 -32.8
1.11.06.01. Transmembrane protease serine 9 TMPS9_HUMAN Homo sapiens Plasma memb. In 28-50 (23-59) 36.8 ± 1.8 3 ± 0 -17.8 -43.3
1.11.06.01. Transmembrane protease serine 12 TMPSC_HUMAN Homo sapiens Plasma memb. Out 330-348 (328-348) 28.8 ± 2.7 2 ± 1 -7.2 -17.0
1.11.06.01. Transmembrane protease serine 13 TMPSD_HUMAN Homo sapiens Plasma memb. In 160-186 (160-187) 34.4 ± 4.0 27 ± 3 -22.7 -27.7
1.11.06.01. Tryptase gamma TRYG1_HUMAN Homo sapiens Plasma memb. Out 281-309 (281-309) 34.0 ± 4.8 28 ± 0 -13.8 -27.8
1.11.06.02. Serine protease HTRA2, mitochondrial HTRA2_HUMAN Homo sapiens Mito. inner memb. In 103-124 (99-126) 32.6 ± 3.2 0 ± 0 -9.4 -16.5
1.11.06.02. Serine endoprotease DegS DEGS_ECOLI Escherichia coli Gram-neg. inner In 5-27 (3-29) 30.8 ± 5.2 29 ± 5 -10.5 -20.4
1.11.06.03. Suppressor of tumorigenicity 14 protein ST14_HUMAN Homo sapiens Plasma memb. In 54-79 (54-85) 39.2 ± 2.0 0 ± 1 -25.2 -52.1
1.11.06.04. Atrial natriuretic peptide-converting enzyme CORIN_HUMAN Homo sapiens Plasma memb. In 42-70 (39-74) 40.8 ± 4.6 6 ± 4 -24.2 -36.0
1.11.07.01. Proprotein convertase subtilisin/kexin type 5 PCSK5_HUMAN Homo sapiens Golgi memb. Out 1740-1765 (1737-1768) 35.2 ± 5.6 16 ± 11 -19.8 -25.8
1.11.07.01. Furin FURIN_HUMAN Homo sapiens Golgi memb. Out 714-736 (711-737) 33.6 ± 3.2 2 ± 1 -19.3 -39.0
1.11.07.01. Membrane-bound transcription factor site-1 protease MBTP1_HUMAN Homo sapiens Golgi memb. Out 1001-1022 (1001-1026) 31.0 ± 3.3 13 ± 3 -18.6 -27.0
1.11.07.01. Proprotein convertase subtilisin/kexin type 4 PCSK4_HUMAN Homo sapiens Lysosome memb. Out 706-729 (706-729) 30.8 ± 3.2 26 ± 20 -8.7 -16.9
1.11.07.01. Proprotein convertase subtilisin/kexin type 7 PCSK7_HUMAN Homo sapiens Golgi memb. Out 657-678 (656-685) 30.4 ± 4.6 15 ± 1 -12.1 -22.5
1.11.07.01. Uncharacterized protein Q55E86_DICDI Dictyostelium discoideum Membrane Out 656-680 (652-684) 30.4 ± 5.6 27 ± 1 -15.7 -21.1
1.11.07.01. Uncharacterized protein Q55C28_DICDI Dictyostelium discoideum Membrane Out 658-679 (656-679) 31.4 ± 2.3 12 ± 9 -10.4 -25.7
1.11.07.01. Kexin KEX2_YEAST Saccharomyces cerevisiae Golgi memb. Out 673-701 (673-703) 30.8 ± 4.0 46 ± 11 -24.5 -28.4
1.11.07.02. Serine carboxypeptidase S10 family member 2 SCPL2_DICDI Dictyostelium discoideum Membrane Out 521-550 (521-554) 42.0 ± 2.2 0 ± 0 -13.9 -41.3
1.11.07.02. Pheromone-processing carboxypeptidase KEX1 KEX1_YEAST Saccharomyces cerevisiae Golgi memb. Out 616-637 (609-645) 31.6 ± 2.8 6 ± 9 -21.8 -23.7
1.11.08.01. Mitochondrial inner membrane protease subunit 2 IMP2L_HUMAN Homo sapiens Mito. inner memb. In 12-34 (7-38) 29.4 ± 3.4 31 ± 16 -4.8 -21.2
1.11.08.01. Thylakoidal processing peptidase 1, chloroplastic TPP1_ARATH Arabidopsis thaliana Thyl. memb. In 156-174 (155-175) 27.6 ± 1.7 13 ± 11 -5.0 -12.9
1.11.08.01. Probable thylakoidal processing peptidase 2, chloroplastic TPP2_ARATH Arabidopsis thaliana Thyl. memb. In 186-204 (185-205) 26.8 ± 1.8 15 ± 11 -4.9 -13.1
1.11.08.01. Signal peptidase I Q9LW08_ARATH Arabidopsis thaliana ER memb. In 15-40 (9-41) 32.8 ± 3.2 31 ± 5 -14.4 -18.5
1.11.08.01. Chloroplast processing peptidase PLSP1_ARATH Arabidopsis thaliana Thyl. memb. In 114-133 (113-134) 29.8 ± 3.0 1 ± 1 -9.0 -14.6
1.11.08.01. Uncharacterized protein Q54RP1_DICDI Dictyostelium discoideum Mito. inner memb. Out 280-302 (278-305) 29.0 ± 2.2 36 ± 0 -11.5 -24.4
1.11.08.01. Mitochondrial inner membrane protease subunit 2 IMP2_YEAST Saccharomyces cerevisiae Mito. inner memb. Out 135-152 (135-152) 26.8 ± 0.8 11 ± 13 -3.9 -12.4
1.11.08.02. Signal peptidase complex catalytic subunit SEC11A SC11A_HUMAN Homo sapiens ER memb. In 18-42 (15-46) 30.8 ± 3.6 30 ± 4 -6.3 -17.9
1.11.08.02. Putative signal peptidase complex catalytic subunit SEC11B SC11B_HUMAN Homo sapiens ER memb. In 6-31 (3-34) 30.8 ± 3.8 31 ± 3 -7.7 -17.6
1.11.08.02. Signal peptidase complex catalytic subunit SEC11C SC11C_HUMAN Homo sapiens ER memb. In 30-55 (27-59) 30.0 ± 3.2 42 ± 4 -8.4 -19.6
1.11.08.02. Signal peptidase complex catalytic subunit sec11 SEC11_DICDI Dictyostelium discoideum ER memb. In 20-41 (20-46) 29.8 ± 3.9 33 ± 3 -10.3 -18.0
1.11.08.02. Signal peptidase complex catalytic subunit SEC11 SEC11_YEAST Saccharomyces cerevisiae ER memb. In 4-27 (4-34) 26.0 ± 4.0 47 ± 0 -10.9 -18.6
1.11.08.02. Uncharacterized protein MJ0260 Y260_METJA Methanococcus jannaschii Archaebacterial memb. Out 174-195 (173-202) 29.8 ± 1.7 30 ± 1 -8.4 -19.2
1.11.09.01. Inactive dipeptidyl peptidase 10 DPP10_HUMAN Homo sapiens Plasma memb. In 32-57 (32-57) 34.4 ± 2.0 21 ± 18 -19.3 -25.6
1.11.09.01. Dipeptidyl peptidase 4 DPP4_HUMAN Homo sapiens Plasma memb. In 4-28 (4-30) 36.4 ± 2.2 13 ± 3 -14.8 -24.9
1.11.09.01. Dipeptidyl aminopeptidase-like protein 6 DPP6_HUMAN Homo sapiens Plasma memb. In 93-117 (93-118) 34.0 ± 1.2 0 ± 0 -19.9 -45.3
1.11.09.01. Seprase SEPR_HUMAN Homo sapiens Plasma memb. In 4-26 (3-27) 32.4 ± 3.2 0 ± 0 -15.2 -42.2
1.11.09.01. Dipeptidyl aminopeptidase A STE13_YEAST Saccharomyces cerevisiae Golgi memb. In 119-144 (114-144) 34.0 ± 5.2 20 ± 19 -20.5 -27.6
1.11.09.01. Dipeptidyl aminopeptidase B DAP2_YEAST Saccharomyces cerevisiae Vacuole memb. In 20-48 (12-48) 28.0 ± 0.8 48 ± 1 -14.8 -22.8
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 19 UBP19_HUMAN Homo sapiens ER memb. In 1287-1309 (1284-1309) 33.0 ± 3.0 1 ± 0 -15.0 -21.0
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 30 UBP30_HUMAN Homo sapiens Mito. outer memb. Out 35-57 (35-63) 32.6 ± 3.9 4 ± 10 -13.0 -14.5
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 27 UBP27_ARATH Arabidopsis thaliana Mito. outer memb. Out 26-46 (23-47) 29.0 ± 2.1 9 ± 7 -9.1 -11.9
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 19 UBP19_ARATH Arabidopsis thaliana ER memb. Out 13-34 (12-36) 30.0 ± 2.5 13 ± 2 -16.3 -24.5
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 16 UBP16_ARATH Arabidopsis thaliana Mito. outer memb. Out 7-27 (7-37) 31.2 ± 2.5 5 ± 4 -12.4 -21.0
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 18 UBP18_ARATH Arabidopsis thaliana Membrane Out 10-31 (10-36) 30.8 ± 3.3 11 ± 11 -15.7 -25.2
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 15 UBP15_ARATH Arabidopsis thaliana Membrane Out 8-27 (8-31) 28.0 ± 3.8 25 ± 0 -15.9 -26.4
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 27 F4JVD6_ARATH Arabidopsis thaliana Mito. outer memb. Out 26-46 (23-47) 29.0 ± 2.1 9 ± 7 -9.1 -11.9
1.11.10.01. Ubiquitin carboxyl-terminal hydrolase 1 UBP1_YEAST Saccharomyces cerevisiae ER memb. Out 36-53 (36-53) 26.8 ± 0.6 6 ± 1 -7.7 -18.2
1.11.11.01. Probable protease SohB SOHB_ECOLI Escherichia coli Gram-neg. inner Out 10-32 (6-38) 32.4 ± 5.4 2 ± 1 -23.0 -24.3
1.11.11.01. Protease 4 SPPA_ECOLI Escherichia coli Gram-neg. inner In 22-43 (22-46) 28.8 ± 3.6 33 ± 0 -15.8 -23.1
1.11.11.01. Putative protease MJ0651 Y651_METJA Methanococcus jannaschii Archaebacterial memb. Und 2-28 (2-30) 30.8 ± 4.8 52 ± 0 -25.5 -28.0
1.11.12.01. Signal peptidase complex subunit 3 SPCS3_HUMAN Homo sapiens ER memb. In 11-32 (7-36) 32.8 ± 2.2 0 ± 0 -15.4 -31.5
1.11.12.01. Signal peptidase complex subunit 3A SPC3A_ARATH Arabidopsis thaliana ER memb. In 8-29 (6-29) 30.6 ± 3.1 13 ± 7 -15.6 -19.1
1.11.12.01. Signal peptidase complex subunit 3B SPC3B_ARATH Arabidopsis thaliana ER memb. In 8-29 (6-29) 30.6 ± 2.8 13 ± 6 -16.3 -19.3
1.11.12.01. Signal peptidase complex subunit 3 SPCS3_DICDI Dictyostelium discoideum ER memb. In 8-29 (4-30) 30.4 ± 3.9 1 ± 24 -11.3 -21.3
1.11.12.01. Signal peptidase complex subunit SPC3 SPC3_YEAST Saccharomyces cerevisiae ER memb. In 13-33 (11-35) 30.0 ± 2.1 3 ± 3 -10.9 -20.1
1.11.13.01. Uncharacterized protein MJ1495 Y1495_METJA Methanococcus jannaschii Archaebacterial memb. In 15-39 (13-45) 31.2 ± 4.2 21 ± 16 -23.0 -28.2
1.11.13.01. Uncharacterized protein MJ0137 Y137_METJA Methanococcus jannaschii Archaebacterial memb. In 9-28 (8-28) 29.0 ± 2.5 15 ± 10 -12.3 -13.2
1.11.14.01. Protein MRG3-like MGR3L_YEAST Saccharomyces cerevisiae Mito. inner memb. In 51-72 (50-76) 30.6 ± 2.0 7 ± 4 -7.3 -16.2
1.11.14.01. Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3 MGR3_YEAST Saccharomyces cerevisiae Mito. inner memb. In 79- 97 (77-100) 27.2 ± 1.9 1 ± 1 -6.2 -15.8
1.11.15.01. Nicastrin NICA_HUMAN Homo sapiens Plasma memb. Out 667-690 (667-694) 34.4 ± 1.8 9 ± 6 -16.9 -23.8
1.11.15.01. Nicastrin NICA_ARATH Arabidopsis thaliana Plasma memb. Out 644-673 (642-674) 34.4 ± 2.6 35 ± 8 -13.6 -19.4
1.11.15.01. Nicastrin NICA_DICDI Dictyostelium discoideum Plasma memb. Out 626-652 (623-656) 35.2 ± 4.4 23 ± 11 -12.8 -27.9
1.11.15.02. Nicalin NCLN_HUMAN Homo sapiens ER memb. Out 521-542 (521-544) 31.8 ± 2.0 22 ± 11 -11.7 -17.9
1.11.15.02. Nicalin Q9M292_ARATH Arabidopsis thaliana ER memb. Out 515-544 (513-545) 42.8 ± 0.4 0 ± 0 -21.0 -49.6
1.11.16.01. Metalloprotease TIKI2 TIKI2_HUMAN Homo sapiens Plasma memb. Out 492-514 (491-514) 32.6 ± 2.4 3 ± 0 -10.6 -18.4
1.11.16.01. Metalloprotease TIKI1 TIKI1_HUMAN Homo sapiens Plasma memb. Out 478-501 (473-501) 34.0 ± 2.4 4 ± 1 -8.0 -19.2
1.11.16.01. TraB domain-containing protein TRABD_HUMAN Homo sapiens Plasma memb. Out 327-350 (325-352) 32.0 ± 3.0 19 ± 7 -4.4 -17.4
1.11.16.01. At1g05270 Q8GXY6_ARATH Arabidopsis thaliana Membrane Out 345-367 (342-370) 29.6 ± 1.2 0 ± 0 -12.2 -32.4
1.11.16.01. TraB family protein F4ITP5_ARATH Arabidopsis thaliana Plasma memb. Out 332-359 (331-359) 36.8 ± 2.2 27 ± 18 -9.1 -21.9
1.11.16.01. Uncharacterized protein Q556R8_DICDI Dictyostelium discoideum Membrane Out 677-698 (676-700) 30.0 ± 1.4 17 ± 7 -7.4 -19.9
1.11.17.01. Uncharacterized protein YpfJ YPFJ_ECOLI Escherichia coli Gram-neg. inner Und 34-52 (32-55) 27.6 ± 2.3 9 ± 7 -7.1 -16.9
1.11.18.01. Phospholipase B1, membrane-associated PLB1_HUMAN Homo sapiens Plasma memb. Out 1415-1440 (1413-1442) 35.2 ± 3.2 10 ± 7 -11.6 -19.1
1.11.18.01. Inactive GDSL esterase/lipase-like protein 25 GDL21_ARATH Arabidopsis thaliana ER memb. In 25-54 (23-56) 30.8 ± 2.4 42 ± 37 -13.7 -20.7
1.11.18.01. GDSL esterase/lipase At2g19060 GDL37_ARATH Arabidopsis thaliana Plasma memb. Out 324-349 (323-349) 36.8 ± 3.2 6 ± 3 -7.5 -14.9
1.11.19.01. Neuropathy target esterase PLPL6_HUMAN Homo sapiens ER memb. Out 45-74 (45-75) 35.2 ± 0.8 0 ± 0 -18.1 -52.3
1.11.19.01. Patatin-like phospholipase domain-containing protein 7 PLPL7_HUMAN Homo sapiens ER memb. Out 12-34 (7-37) 30.8 ± 1.4 0 ± 0 -23.5 -52.7
1.11.19.02. Patatin-like phospholipase domain-containing protein 2 PLPL2_HUMAN Homo sapiens Lipid droplet Out 7-26 (3-32) 26.0 ± 1.8 0 ± 0 -4.0 -23.4
1.11.19.02. Patatin-like phospholipase domain-containing protein 3 PLPL3_HUMAN Homo sapiens ER memb. Out 7-26 (3-27) 25.6 ± 2.2 0 ± 5 -3.0 -24.8
1.11.19.02. Calcium-independent phospholipase A2-gamma PLPL8_HUMAN Homo sapiens ER memb. Out 480-499 (476-499) 29.2 ± 4.0 6 ± 3 -9.2 -14.3
1.11.19.03. Lipase 5 TGL5_YEAST Saccharomyces cerevisiae Lipid droplet Out 181-204 (180-205) 26.0 ± 3.8 39 ± 5 -5.3 -13.6
1.11.19.03. Lipase 3 TGL3_YEAST Saccharomyces cerevisiae Lipid droplet Out 201-223 (199-225) 29.4 ± 2.7 28 ± 6 -3.0 -11.4
1.11.19.03. Lipase 4 TGL4_YEAST Saccharomyces cerevisiae Lipid droplet Out 282-303 (279-304) 26.8 ± 7.0 33 ± 2 -4.3 -12.2
1.11.20.01. Arylacetamide deacetylase AAAD_HUMAN Homo sapiens ER memb. In 3-21 (3-21) 27.2 ± 1.6 10 ± 7 -7.6 -15.1
1.11.20.01. Neutral cholesterol ester hydrolase 1 NCEH1_HUMAN Homo sapiens ER memb. In 3-21 (2-21) 27.0 ± 1.2 11 ± 1 -10.2 -16.3
1.11.20.01. Arylacetamide deacetylase-like 4 ADCL4_HUMAN Homo sapiens ER memb. In 2-24 (2-25) 31.6 ± 1.2 32 ± 5 -19.3 -28.7
1.11.20.01. Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1 ICML1_ARATH Arabidopsis thaliana ER memb. In 149-175 (147-176) 36.0 ± 1.6 1 ± 1 -8.1 -34.2
1.11.20.01. Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2 ICML2_ARATH Arabidopsis thaliana ER memb. In 93-119 (91-126) 39.2 ± 1.8 4 ± 3 -13.6 -36.3
1.11.20.01. Isoprenylcysteine alpha-carbonyl methylesterase ICME ICME_ARATH Arabidopsis thaliana ER memb. In 98-124 (96-130) 33.6 ± 3.8 29 ± 0 -12.5 -24.3
1.11.20.02. Monoacylglycerol lipase ABHD6 ABHD6_HUMAN Homo sapiens Vesicle memb. In 5-34 (5-38) 31.6 ± 1.0 45 ± 0 -17.4 -29.2
1.11.20.02. Epoxide hydrolase 4 EPHX4_HUMAN Homo sapiens Vesicle memb. In 19-40 (15-45) 36.8 ± 8.8 7 ± 3 -4.9 -16.5
1.11.20.02. Mesoderm-specific transcript homolog protein MEST_HUMAN Homo sapiens ER memb. In 10-30 (5-31) 27.8 ± 1.7 10 ± 2 -8.8 -19.6
1.11.20.02. AT5G53050 protein B9DG68_ARATH Arabidopsis thaliana Membrane Out 357-378 (357-381) 29.4 ± 2.0 31 ± 25 -17.6 -22.7
1.11.20.03. Abhydrolase domain-containing protein 1 ABHD1_HUMAN Homo sapiens Vesicle memb. In 13-34 (12-35) 30.2 ± 2.8 11 ± 1 -13.0 -19.8
1.11.20.03. Abhydrolase domain-containing protein 2 ABHD2_HUMAN Homo sapiens Vesicle memb. In 12-33 (11-37) 31.6 ± 3.5 7 ± 17 -6.0 -17.8
1.11.20.03. Abhydrolase domain-containing protein 3 ABHD3_HUMAN Homo sapiens Vesicle memb. In 27-49 (20-55) 32.0 ± 3.0 1 ± 1 -10.6 -18.5
1.11.20.03. Alpha/beta-Hydrolases superfamily protein Q9SF34_ARATH Arabidopsis thaliana Membrane Und 122-143 (122-146) 30.6 ± 3.9 23 ± 2 -17.1 -21.0
1.11.20.03. AT5g02970/F9G14_280 Q9LYY8_ARATH Arabidopsis thaliana Membrane Und 119-140 (119-140) 33.2 ± 3.7 18 ± 1 -18.4 -20.0
1.11.20.03. Uncharacterized protein Q55FN8_DICDI Dictyostelium discoideum Membrane Und 71-92 (70-92) 33.8 ± 2.5 2 ± 0 -14.0 -23.5
1.11.20.04. Alpha/beta-Hydrolases superfamily protein F4HXL0_ARATH Arabidopsis thaliana Membrane Und 688-712 (688-712) 31.6 ± 2.6 29 ± 0 -9.3 -21.8
1.11.20.04. AT3g62590/F26K9_20 Q940L4_ARATH Arabidopsis thaliana Membrane Und 615-633 (611-642) 28.4 ± 4.2 26 ± 1 -8.8 -20.7
1.11.20.04. Putative lipase ATG15 ATG15_YEAST Saccharomyces cerevisiae ER memb. In 14-35 (14-35) 32.0 ± 1.8 16 ± 0 -12.5 -17.8
1.11.20.05. Monoacylglycerol lipase ABHD12 ABD12_HUMAN Homo sapiens Plasma memb. In 69-93 (68-93) 34.4 ± 4.2 9 ± 11 -8.4 -23.0
1.11.20.05. Alpha/beta hydrolase domain-containing protein 13 ABHDD_HUMAN Homo sapiens Plasma memb. In 32-60 (32-61) 34.4 ± 4.0 42 ± 2 -20.5 -28.5
1.11.20.05. Bem46-family protein WAV2 Q8RXP6_ARATH Arabidopsis thaliana Membrane Und 4-29 (4-30) 32.0 ± 2.6 29 ± 0 -12.4 -20.4
1.11.20.05. Alpha/beta-Hydrolases superfamily protein Q9C915_ARATH Arabidopsis thaliana Membrane Und 3-21 (3-25) 30.6 ± 2.6 1 ± 0 -10.8 -18.0
1.11.20.05. Uncharacterized protein Q54H73_DICDI Dictyostelium discoideum Membrane Und 8-29 (2-32) 31.2 ± 3.3 2 ± 1 -12.3 -14.1
1.11.20.05. Tentative alpha/beta-hydrolase YN60_YEAST Saccharomyces cerevisiae Plasma memb. In 4-26 (3-31) 34.0 ± 3.0 1 ± 14 -11.7 -19.1
1.11.20.05. Uncharacterized protein YfhR YFHR_ECOLI Escherichia coli Gram-neg. inner Und 9-29 (8-30) 29.6 ± 2.5 15 ± 3 -8.9 -24.1
1.11.20.06. Alpha/beta hydrolase domain-containing protein 14A ABHEA_HUMAN Homo sapiens Vesicle memb. In 32-52 (29-52) 27.2 ± 1.2 0 ± 0 -13.6 -34.0
1.11.20.07. Transmembrane protein 53 TMM53_HUMAN Homo sapiens Membrane Und 167-200 (167-204) 28.8 ± 2.8 59 ± 5 -27.4 -35.6
1.11.20.07. Uncharacterized protein Q54YR8_DICDI Dictyostelium discoideum Membrane Und 156-178 (154-178) 31.2 ± 1.8 8 ± 6 -20.8 -28.3
1.11.20.07. Uncharacterized protein Q54N85_DICDI Dictyostelium discoideum Membrane Und 194-216 (192-218) 31.6 ± 3.0 2 ± 1 -9.3 -21.3
1.11.20.08. Phospholipid:diacylglycerol acyltransferase 1 PDAT1_ARATH Arabidopsis thaliana ER memb. In 54-73 (52-75) 21.6 ± 1.6 0 ± 1 -9.9 -25.0
1.11.20.08. Putative phospholipid:diacylglycerol acyltransferase 2 PDAT2_ARATH Arabidopsis thaliana ER memb. In 45-66 (44-66) 22.8 ± 1.6 0 ± 1 -9.4 -20.6
1.11.20.08. Lecithin-cholesterol acyltransferase-like 1 LCAT1_ARATH Arabidopsis thaliana Vacuole memb. In 7-25 (4-26) 27.0 ± 1.6 10 ± 8 -11.6 -14.5
1.11.20.08. Phospholipid--sterol O-acyltransferase LCAT2_ARATH Arabidopsis thaliana ER memb. In 7-26 (3-29) 28.2 ± 2.8 8 ± 6 -10.2 -20.7
1.11.20.08. Phospholipid:diacylglycerol acyltransferase PDAT_YEAST Saccharomyces cerevisiae ER memb. In 78- 98 (75-100) 30.4 ± 3.4 5 ± 4 -14.1 -19.2
1.11.20.09. Sterol esterase 1 YEH1_YEAST Saccharomyces cerevisiae Lipid droplet In 12-36 (3-39) 30.8 ± 4.6 30 ± 0 -21.8 -25.4
1.11.20.09. Sterol esterase 2 YEH2_YEAST Saccharomyces cerevisiae Plasma memb. In 10-32 (8-34) 34.8 ± 1.9 0 ± 0 -15.3 -16.5
1.11.20.09. Sterol esterase TGL1 TGL1_YEAST Saccharomyces cerevisiae ER memb. Out 9-33 (8-33) 30.0 ± 2.7 27 ± 1 -4.8 -16.8
1.11.20.10. Protein AUXIN RESPONSE 4 AXR4_ARATH Arabidopsis thaliana ER memb. In 44-68 (43-70) 30.8 ± 4.4 29 ± 3 -18.4 -24.8
1.11.20.11. Steryl acetyl hydrolase 1 SAY1_YEAST Saccharomyces cerevisiae ER memb. In 48-73 (41-77) 30.8 ± 2.2 38 ± 1 -16.6 -27.1
1.11.20.12. Protein SERAC1 SRAC1_HUMAN Homo sapiens ER memb. In 33-55 (30-58) 32.8 ± 3.3 0 ± 12 -6.8 -14.7
1.11.20.13. Epoxide hydrolase 1 HYEP_HUMAN Homo sapiens ER memb. In 2-19 (2-25) 31.6 ± 3.6 1 ± 20 -8.5 -18.7
1.11.20.14. Putative lipase YOR059C YO059_YEAST Saccharomyces cerevisiae Lipid droplet Und 268-290 (267-302) 34.4 ± 2.0 2 ± 0 -20.2 -26.0
1.11.20.15. Uncharacterized protein F4J7E1_ARATH Arabidopsis thaliana Membrane Und 162-182 (161-182) 29.6 ± 1.8 9 ± 8 -6.7 -12.7
1.11.20.15. Uncharacterized protein YPR147C YP147_YEAST Saccharomyces cerevisiae Membrane Und 159-178 (156-178) 28.4 ± 3.1 3 ± 12 -5.3 -11.2
1.11.20.16. Uncharacterized protein Q54DJ5_DICDI Dictyostelium discoideum Membrane Und 24-47 (22-51) 34.4 ± 2.4 4 ± 3 -14.0 -26.7
1.11.20.17. Alpha/beta fold hydrolase family protein Q9LYG5_ARATH Arabidopsis thaliana Membrane Und 28-47 (28-47) 29.4 ± 2.6 2 ± 5 -10.9 -19.1
1.11.20.18. Esterase/lipase/thioesterase family protein Q9C914_ARATH Arabidopsis thaliana Membrane Und 17-38 (13-41) 32.2 ± 2.7 9 ± 7 -16.1 -23.7
1.11.20.18. Alpha/beta-hydrolase domain-containing protein Q9STM1_ARATH Arabidopsis thaliana Membrane Und 31-52 (28-53) 30.0 ± 2.2 2 ± 3 -13.0 -21.2
1.11.20.19. Putative uncharacterized protein At3g58800/T20N10_150 Q9LXS2_ARATH Arabidopsis thaliana Membrane Und 16-38 (11-40) 34.4 ± 1.9 2 ± 3 -19.4 -28.6
1.11.21.01. Phospholipase D3 PLD3_HUMAN Homo sapiens ER memb. In 38-60 (25-62) 34.8 ± 2.2 0 ± 12 -23.9 -22.3
1.11.21.01. Phospholipase D4 PLD4_HUMAN Homo sapiens ER memb. In 30-54 (25-54) 34.8 ± 2.4 1 ± 3 -14.1 -38.6
1.11.21.01. Inactive phospholipase D5 PLD5_HUMAN Homo sapiens Mito. outer memb. In 65-88 (62-89) 34.8 ± 1.8 2 ± 0 -20.5 -25.9
1.11.21.01. Mitochondrial cardiolipin hydrolase PLD6_HUMAN Homo sapiens Mito. outer memb. Out 6-30 (3-35) 32.0 ± 2.4 0 ± 0 -12.5 -39.3
1.11.22.01. Neutral ceramidase ASAH2_HUMAN Homo sapiens Plasma memb. In 8-37 (8-42) 35.2 ± 4.4 43 ± 11 -26.4 -33.3
1.11.22.01. Neutral/alkaline non-lysosomal ceramidase F4HQM3_ARATH Arabidopsis thaliana Plasma memb. In 12-32 (12-35) 30.2 ± 3.3 22 ± 0 -5.2 -18.2
1.11.23.01. N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial FMP30_YEAST Saccharomyces cerevisiae Mito. inner memb. Und 54-75 (46-81) 26.8 ± 1.5 26 ± 4 -8.3 -15.9
1.11.24.01. Protein phosphatase 1L PPM1L_HUMAN Homo sapiens ER memb. Out 24-41 (24-46) 27.4 ± 2.8 10 ± 1 -7.0 -14.3
1.11.24.01. Probable protein phosphatase 2C 11 P2C11_ARATH Arabidopsis thaliana Membrane Out 36-57 (36-58) 26.8 ± 1.2 2 ± 1 -11.0 -35.9
1.11.24.01. Probable protein phosphatase 2C 51 P2C51_ARATH Arabidopsis thaliana Membrane Out 5-29 (3-29) 28.4 ± 1.6 0 ± 4 -20.6 -42.6
1.11.24.01. Protein phosphatase 2C 57 P2C57_ARATH Arabidopsis thaliana Thyl. memb. In 364-385 (364-387) 31.0 ± 3.8 28 ± 0 -6.0 -14.3
1.11.24.01. Protein phosphatase 2C 70 P2C70_ARATH Arabidopsis thaliana Plasma memb. Out 2-29 (2-29) 34.0 ± 3.2 3 ± 2 -24.5 -49.2
1.11.24.01. Kinase associated protein phosphatase F4K124_ARATH Arabidopsis thaliana Plasma memb. Out 2-29 (2-29) 34.0 ± 3.0 0 ± 1 -24.5 -50.3
1.11.25.01. Serine/threonine-protein phosphatase PGAM5, mitochondrial PGAM5_HUMAN Homo sapiens Mito. outer memb. Out 2-27 (2-28) 29.4 ± 4.4 38 ± 7 -6.5 -10.5
1.11.25.02. Prostatic acid phosphatase, isoform 2 PPAP_HUMAN Homo sapiens Plasma memb. Out 380-402 (377-406) 31.2 ± 1.4 0 ± 0 -24.1 -54.5
1.11.25.02. Lysosomal acid phosphatase PPAL_HUMAN Homo sapiens Lysosome memb. Out 378-406 (378-408) 40.8 ± 1.6 0 ± 0 -26.3 -29.7
1.11.25.02. Testicular acid phosphatase PPAT_HUMAN Homo sapiens Plasma memb. Out 391-415 (391-415) 30.4 ± 3.8 4 ± 3 -14.5 -30.6
1.11.25.02. 2-phosphoxylose phosphatase 1 PXYP1_HUMAN Homo sapiens Golgi memb. In 6-30 (6-30) 33.2 ± 3.0 29 ± 23 -20.4 -24.7
1.11.25.02. Multiple inositol polyphosphate phosphatase 1 MINP1_DICDI Dictyostelium discoideum Plasma memb. Out 566-594 (565-601) 34.4 ± 4.6 29 ± 7 -15.5 -22.9
1.11.26.01. Inositol monophosphatase 3 IMPA3_HUMAN Homo sapiens Golgi memb. In 8-28 (8-29) 28.8 ± 2.7 16 ± 0 -9.2 -17.7
1.11.27.01. Arabinanase/levansucrase/invertase Q9FJW9_ARATH Arabidopsis thaliana Membrane Und 26-46 (18-49) 31.6 ± 1.4 0 ± 0 -19.5 -50.0
1.11.27.01. Glycosyl hydrolase family protein 43 Q9M2X0_ARATH Arabidopsis thaliana Membrane Und 19-39 (19-43) 29.6 ± 2.2 21 ± 1 -10.3 -19.7
1.11.28.01. Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN Homo sapiens Plasma memb. In 74-97 (72-98) 30.4 ± 2.0 9 ± 5 -13.4 -34.1
1.11.28.01. Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 ENPP3_HUMAN Homo sapiens Plasma memb. In 20-45 (17-49) 34.8 ± 3.2 29 ± 23 -21.4 -23.6
1.11.28.01. Ectonucleotide pyrophosphatase/phosphodiesterase family member 4 ENPP4_HUMAN Homo sapiens Plasma memb. Out 404-429 (404-433) 34.4 ± 4.2 37 ± 1 -18.8 -27.2
1.11.28.01. Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 ENPP5_HUMAN Homo sapiens Plasma memb. Out 434-456 (430-459) 33.8 ± 1.7 17 ± 14 -18.6 -25.6
1.11.28.01. Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 ENPP7_HUMAN Homo sapiens Plasma memb. Out 439-458 (439-458) 29.6 ± 2.0 1 ± 1 -1.3 -17.4
1.11.28.01. Alkaline-phosphatase-like protein Q9SU83_ARATH Arabidopsis thaliana Membrane In 47-76 (41-78) 29.2 ± 6.2 49 ± 0 -23.0 -24.5
1.11.28.01. Uncharacterized protein Q54MJ8_DICDI Dictyostelium discoideum Membrane In 136-158 (135-160) 33.6 ± 1.4 9 ± 1 -16.6 -20.7
1.11.28.01. Uncharacterized protein Q54U95_DICDI Dictyostelium discoideum Membrane Out 492-517 (491-519) 32.0 ± 6.2 33 ± 11 -20.4 -27.0
1.11.28.01. Ectonucleotide pyrophosphatase/phosphodiesterase 2 NPP2_YEAST Saccharomyces cerevisiae Plasma memb. In 26-48 (24-48) 33.0 ± 4.0 3 ± 2 -12.1 -22.9
1.11.28.01. Ectonucleotide pyrophosphatase/phosphodiesterase 1 NPP1_YEAST Saccharomyces cerevisiae Plasma memb. In 114-137 (113-137) 34.8 ± 3.8 4 ± 5 -17.6 -23.1
1.11.29.01. Probable polygalacturonase A8MRN3_ARATH Arabidopsis thaliana Plasma memb. Out 430-450 (429-451) 29.4 ± 2.6 15 ± 14 -9.8 -15.7
1.11.29.01. Pectin lyase-like superfamily protein F4IE17_ARATH Arabidopsis thaliana Plasma memb. In 27-49 (18-52) 34.6 ± 1.9 7 ± 5 -11.7 -20.0
1.11.29.01. Pectin lyase-like superfamily protein Q84K13_ARATH Arabidopsis thaliana Plasma memb. In 17-36 (17-39) 29.2 ± 2.6 0 ± 12 -17.5 -21.1
1.11.30.01. CDP-diacylglycerol pyrophosphatase CDH_ECOLI Escherichia coli Gram-neg. inner Out 3-25 (3-27) 34.4 ± 2.1 1 ± 3 -19.4 -23.4
1.11.31.01. Alkaline phosphatase Q54Y02_DICDI Dictyostelium discoideum Vacuole memb. In 79-100 (74-100) 31.2 ± 3.2 19 ± 15 -20.3 -29.2
1.11.31.01. Repressible alkaline phosphatase PPB_YEAST Saccharomyces cerevisiae Vacuole memb. In 32-54 (30-65) 32.8 ± 1.8 10 ± 6 -14.6 -21.2
1.11.31.02. Calcineurin-like metallo-phosphoesterase-like protein F4K1J1_ARATH Arabidopsis thaliana Membrane Und 416-445 (413-450) 42.4 ± 1.2 4 ± 1 -32.4 -63.2
1.11.32.01. Ectonucleoside triphosphate diphosphohydrolase 6 ENTP6_HUMAN Homo sapiens Golgi memb. In 40-61 (35-67) 32.8 ± 2.6 9 ± 4 -8.8 -14.3
1.11.32.01. Apyrase 1 APY1_ARATH Arabidopsis thaliana Golgi memb. In 20-41 (13-41) 32.2 ± 3.6 5 ± 4 -16.7 -22.0
1.11.32.01. Apyrase 2 APY2_ARATH Arabidopsis thaliana Golgi memb. In 20-41 (13-41) 33.2 ± 3.3 5 ± 3 -15.5 -19.4
1.11.32.01. Probable apyrase 3 APY3_ARATH Arabidopsis thaliana Golgi memb. In 26-51 (20-52) 32.4 ± 3.4 30 ± 0 -17.1 -23.4
1.11.32.01. Probable apyrase 4 APY4_ARATH Arabidopsis thaliana Membrane In 44-69 (39-75) 35.2 ± 3.8 28 ± 2 -21.3 -27.5
1.11.32.01. Probable apyrase 5 APY5_ARATH Arabidopsis thaliana Vacuole memb. In 31-53 (25-56) 34.2 ± 1.0 2 ± 6 -18.3 -24.2
1.11.32.01. Golgi apyrase YND1_YEAST Saccharomyces cerevisiae Golgi memb. Out 498-518 (495-525) 32.2 ± 4.0 4 ± 0 -12.1 -20.2
1.11.32.01. Guanosine-diphosphatase GDA1_YEAST Saccharomyces cerevisiae Golgi memb. In 8-28 (8-29) 25.2 ± 1.4 0 ± 0 -16.0 -31.5
1.11.33.01. Uncharacterized protein At2g39920 Y2992_ARATH Arabidopsis thaliana Membrane Und 38-65 (30-67) 40.8 ± 5.6 1 ± 9 -25.8 -29.2
1.11.34.01. Sphingomyelin phosphodiesterase 3 NSMA2_HUMAN Homo sapiens Golgi memb. Out 58-86 (52-86) 34.0 ± 5.8 41 ± 0 -16.6 -27.0
1.11.34.01. Uncharacterized calcium-binding protein At1g02270 YC22_ARATH Arabidopsis thaliana Nucleus memb. Out 25-43 (25-48) 28.0 ± 1.5 21 ± 6 -8.0 -21.5
1.11.34.01. Uncharacterized protein Q55CH5_DICDI Dictyostelium discoideum Membrane In 929-950 (925-954) 29.2 ± 6.4 29 ± 19 -7.7 -15.6
1.11.35.01. Glycerophosphodiester phosphodiesterase 1 GDE1_HUMAN Homo sapiens Plasma memb. Und 6-27 (5-27) 30.0 ± 3.1 2 ± 2 -10.4 -19.1
1.11.35.01. Glycerophosphodiester phosphodiesterase domain-containing protein 3 GDPD3_HUMAN Homo sapiens Membrane In 3-24 (3-25) 32.6 ± 3.9 8 ± 12 -7.8 -15.9
1.11.35.01. Glycerophosphodiester phosphodiesterase GDPD4 GDPD4_ARATH Arabidopsis thaliana Plasma memb. Und 32-54 (29-58) 33.2 ± 2.0 9 ± 7 -18.1 -27.6
1.11.35.01. Glycerophosphodiester phosphodiesterase GDPDL5 GPDL5_ARATH Arabidopsis thaliana Plasma memb. Und 705-727 (705-729) 31.0 ± 2.4 35 ± 5 -13.4 -26.0
1.11.35.01. Glycerophosphodiester phosphodiesterase GDPDL6 GPDL6_ARATH Arabidopsis thaliana Plasma memb. Und 730-752 (730-752) 32.4 ± 2.4 17 ± 1 -11.1 -16.1
1.11.35.01. Putative glycerophosphoryl diester phosphodiesterase 3 F4HQ30_ARATH Arabidopsis thaliana Membrane Und 767-785 (764-785) 28.6 ± 2.9 0 ± 0 -7.1 -18.2
1.11.35.01. Phosphatidylglycerol phospholipase C PGC1_YEAST Saccharomyces cerevisiae Mito. outer memb. In 297-318 (296-321) 29.4 ± 5.2 29 ± 20 -9.0 -14.2
1.11.35.02. Uncharacterized protein Q556N9_DICDI Dictyostelium discoideum Membrane Und 935-963 (931-966) 35.6 ± 5.4 30 ± 2 -32.1 -30.8
1.11.36.01. Sphingomyelin phosphodiesterase 4 NSMA3_HUMAN Homo sapiens ER memb. Out 797-815 (797-821) 27.2 ± 2.1 30 ± 0 -10.1 -18.1
1.11.37.01. Phosphatidylglycerophosphatase C PGPC_ECOLI Escherichia coli Gram-neg. inner In 35-57 (35-59) 31.8 ± 3.0 31 ± 20 -13.7 -23.8
1.11.38.01. N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase NAGPA_HUMAN Homo sapiens Golgi memb. Out 444-470 (444-480) 39.2 ± 0.2 2 ± 0 -23.8 -57.5
1.11.39.01. Klotho KLOT_HUMAN Homo sapiens Plasma memb. Out 979-1004 (976-1006) 36.0 ± 1.2 0 ± 0 -23.3 -41.8
1.11.39.01. Beta-klotho KLOTB_HUMAN Homo sapiens Plasma memb. Out 996-1020 (996-1023) 34.4 ± 2.0 24 ± 4 -16.0 -23.1
1.11.39.01. Lactase-like protein LCTL_HUMAN Homo sapiens ER memb. Out 536-563 (535-566) 39.6 ± 4.6 5 ± 5 -15.8 -25.2
1.11.39.01. Lactase-phlorizin hydrolase LPH_HUMAN Homo sapiens Plasma memb. Out 1882-1904 (1877-1909) 34.0 ± 1.1 1 ± 1 -19.5 -21.5
1.11.39.01. Beta-glucosidase 26, peroxisomal BGL26_ARATH Arabidopsis thaliana Plasma memb. Out 534-558 (534-558) 34.4 ± 3.6 22 ± 10 -8.3 -16.3
1.11.39.02. Uncharacterized family 31 glucosidase KIAA1161 K1161_HUMAN Homo sapiens Nucleus memb. In 57-79 (56-83) 33.2 ± 2.8 0 ± 14 -19.1 -23.0
1.11.39.02. Maltase-glucoamylase, intestinal MGA_HUMAN Homo sapiens Plasma memb. In 11-36 (11-40) 34.0 ± 3.2 35 ± 0 -28.3 -35.0
1.11.39.02. Probable maltase-glucoamylase-like protein LOC93432 MGAL2_HUMAN Homo sapiens Membrane In 7-32 (7-35) 36.0 ± 1.6 0 ± 1 -20.4 -39.7
1.11.39.02. Sucrase-isomaltase, intestinal SUIS_HUMAN Homo sapiens Plasma memb. In 8-35 (8-35) 36.0 ± 5.0 29 ± 1 -28.9 -34.6
1.11.39.03. Hyaluronidase-4 HYAL4_HUMAN Homo sapiens Plasma memb. In 9-33 (6-33) 34.4 ± 1.8 9 ± 5 -8.7 -15.9
1.11.39.04. Glycoprotein endo-alpha-1,2-mannosidase MANEA_HUMAN Homo sapiens Golgi memb. In 7-29 (2-30) 31.6 ± 3.4 27 ± 21 -21.4 -27.0
1.11.39.04. Glycoprotein endo-alpha-1,2-mannosidase-like protein MANEL_HUMAN Homo sapiens Golgi memb. In 8-29 (2-31) 32.4 ± 2.0 7 ± 5 -18.6 -25.7
1.11.39.05. Uncharacterized protein MJ1477 Y1477_METJA Methanococcus jannaschii Archaebacterial memb. Und 12-33 (9-33) 32.8 ± 3.4 11 ± 10 -16.6 -20.8
1.11.39.06. Beta-galactosidase 9 BGAL9_ARATH Arabidopsis thaliana Membrane Und 9-28 (9-33) 27.8 ± 3.3 10 ± 5 -11.0 -17.7
1.11.39.07. Galactose-binding domain-containing protein Q54MD5_DICDI Dictyostelium discoideum Membrane Und 530-549 (527-549) 29.4 ± 2.3 2 ± 1 -12.7 -17.3
1.11.39.07. Uncharacterized protein Q54MB3_DICDI Dictyostelium discoideum Membrane Und 522-542 (518-542) 29.8 ± 3.7 0 ± 1 -12.4 -22.2
1.11.39.08. Glycosyl hydrolase family protein Q9M159_ARATH Arabidopsis thaliana ER memb. Und 34-56 (30-56) 34.4 ± 1.4 5 ± 5 -21.4 -26.1
1.11.40.01. Lysosomal alpha-mannosidase MA2B1_HUMAN Homo sapiens Plasma memb. In 31-48 (31-49) 27.0 ± 3.3 15 ± 4 -6.7 -17.2
1.11.40.01. Alpha-mannosidase 2 MA2A1_HUMAN Homo sapiens Golgi memb. In 6-26 (4-28) 28.8 ± 1.6 0 ± 0 -12.1 -35.1
1.11.40.01. Alpha-mannosidase 2x MA2A2_HUMAN Homo sapiens Golgi memb. In 5-26 (4-28) 30.8 ± 2.6 1 ± 1 -10.7 -29.4
1.11.40.01. Alpha-mannosidase 2 GMAN2_ARATH Arabidopsis thaliana Golgi memb. In 46-77 (40-77) 40.4 ± 0.4 0 ± 5 -24.3 -59.7
1.11.40.01. Alpha-mannosidase D MAND_DICDI Dictyostelium discoideum Plasma memb. Out 1168-1193 (1167-1197) 35.2 ± 3.4 27 ± 21 -21.7 -25.6
1.11.40.01. Alpha-mannosidase E MANE_DICDI Dictyostelium discoideum Plasma memb. Out 1070-1095 (1069-1101) 38.4 ± 1.2 0 ± 0 -19.2 -42.3
1.11.41.01. ER degradation-enhancing alpha-mannosidase-like protein 1 EDEM1_HUMAN Homo sapiens ER memb. In 12-35 (10-37) 31.2 ± 2.8 31 ± 0 -5.8 -15.8
1.11.41.01. Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA MA1A1_HUMAN Homo sapiens Golgi memb. In 38-62 (33-62) 37.6 ± 2.6 7 ± 5 -18.7 -29.8
1.11.41.01. Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB MA1A2_HUMAN Homo sapiens Golgi memb. In 35-57 (35-57) 34.8 ± 0.7 7 ± 5 -18.9 -26.1
1.11.41.01. Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MA1B1_HUMAN Homo sapiens ER memb. In 81-102 (80-111) 33.2 ± 2.1 8 ± 6 -20.9 -26.9
1.11.41.01. Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC MA1C1_HUMAN Homo sapiens Golgi memb. In 20-43 (20-43) 31.6 ± 3.4 31 ± 1 -14.7 -24.2
1.11.41.01. Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 MNS3_ARATH Arabidopsis thaliana Golgi memb. In 45-66 (41-67) 31.6 ± 2.8 6 ± 5 -17.0 -25.4
1.11.41.01. Probable alpha-mannosidase I MNS4 MNS4_ARATH Arabidopsis thaliana ER memb. In 5-28 (3-31) 34.4 ± 4.0 0 ± 0 -16.0 -20.8
1.11.41.01. Probable alpha-mannosidase I MNS5 MNS5_ARATH Arabidopsis thaliana ER memb. In 7-27 (7-28) 28.8 ± 2.2 2 ± 2 -2.0 -15.8
1.11.41.01. Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 MNS1_ARATH Arabidopsis thaliana Golgi memb. In 25-46 (23-50) 32.0 ± 2.8 1 ± 3 -9.1 -22.4
1.11.41.01. Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS2 MNS2_ARATH Arabidopsis thaliana Golgi memb. In 26-47 (24-50) 32.0 ± 2.8 1 ± 1 -8.2 -21.8
1.11.41.01. alpha-1,2-Mannosidase Q54PP9_DICDI Dictyostelium discoideum Membrane In 3-24 (3-26) 29.6 ± 3.4 35 ± 0 -18.5 -22.5
1.11.41.01. alpha-1,2-Mannosidase Q55EU0_DICDI Dictyostelium discoideum Membrane In 6-26 (6-26) 30.8 ± 2.7 22 ± 2 -14.1 -21.9
1.11.41.01. alpha-1,2-Mannosidase Q54CH4_DICDI Dictyostelium discoideum Membrane In 7-29 (7-29) 34.4 ± 1.7 6 ± 5 -18.9 -24.8
1.11.41.01. Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1_YEAST Saccharomyces cerevisiae ER memb. In 5-26 (4-31) 30.4 ± 2.5 12 ± 7 -14.8 -18.7
1.11.41.01. Putative endoplasmic reticulum mannosidase MNL2 MNL2_YEAST Saccharomyces cerevisiae ER memb. In 10-31 (8-33) 29.8 ± 3.9 11 ± 7 -11.3 -22.4
1.11.41.02. Endoglucanase 25 GUN25_ARATH Arabidopsis thaliana Plasma memb. In 72-96 (66-96) 32.0 ± 1.8 0 ± 0 -18.9 -44.2
1.11.41.02. Endoglucanase 7 GUN7_ARATH Arabidopsis thaliana Plasma memb. In 79-104 (74-104) 34.8 ± 3.6 13 ± 0 -18.5 -32.2
1.11.41.02. Endoglucanase 21 GUN21_ARATH Arabidopsis thaliana Plasma memb. In 71-96 (66-96) 34.0 ± 2.6 22 ± 1 -16.3 -26.8
1.11.41.03. Mannosyl-oligosaccharide glucosidase MOGS_HUMAN Homo sapiens ER memb. In 41-65 (37-69) 31.2 ± 5.4 29 ± 22 -12.2 -14.7
1.11.41.03. Mannosyl-oligosaccharide glucosidase GCS1 GCS1_ARATH Arabidopsis thaliana ER memb. In 46-68 (43-74) 32.0 ± 3.8 21 ± 6 -15.9 -26.0
1.11.41.03. Mannosyl-oligosaccharide glucosidase CWH41_YEAST Saccharomyces cerevisiae ER memb. In 7-28 (5-31) 30.4 ± 3.8 26 ± 3 -10.6 -22.8
1.11.42.01. Sperm acrosome membrane-associated protein 1 SACA1_HUMAN Homo sapiens Lysosome memb. Out 217-253 (217-254) 34.0 ± 2.8 56 ± 4 -33.7 -37.2
1.11.42.01. Sperm acrosome membrane-associated protein 3 SACA3_HUMAN Homo sapiens Lysosome memb. In 64-83 (64-87) 27.6 ± 1.3 1 ± 2 -8.0 -17.5
1.11.43.01. ADP-ribosyl cyclase 1 CD38_HUMAN Homo sapiens Plasma memb. In 22-43 (20-43) 33.4 ± 2.6 0 ± 0 -16.6 -23.5
1.11.44.01. Soluble calcium-activated nucleotidase 1 CANT1_HUMAN Homo sapiens ER memb. In 43-62 (41-63) 24.4 ± 3.8 0 ± 0 -11.7 -28.5
1.11.45.01. Probable endonuclease LCL3 LCL3_YEAST Saccharomyces cerevisiae Nucleus inner memb. Und 11-32 (5-35) 33.0 ± 2.4 9 ± 9 -11.5 -17.2
1.11.46.01. Ribonuclease MRP protein subunit RMP1 RMP1_YEAST Saccharomyces cerevisiae Nucleus inner memb. Und 91-112 (87-113) 29.6 ± 2.8 24 ± 4 -5.3 -15.9
1.11.47.01. Probable pectinesterase/pectinesterase inhibitor 34 PME34_ARATH Arabidopsis thaliana Plasma memb. In 44-66 (35-70) 34.4 ± 2.3 1 ± 15 -20.2 -21.5
1.11.47.01. Putative pectinesterase/pectinesterase inhibitor 45 PME45_ARATH Arabidopsis thaliana Plasma memb. In 23-49 (15-52) 36.0 ± 1.6 0 ± 0 -20.6 -46.9
1.11.47.01. Probable pectinesterase/pectinesterase inhibitor 46 PME46_ARATH Arabidopsis thaliana Plasma memb. In 21-46 (16-53) 38.8 ± 4.8 4 ± 6 -18.8 -22.8
1.11.47.01. Probable pectinesterase/pectinesterase inhibitor 61 PME61_ARATH Arabidopsis thaliana Plasma memb. In 30-58 (25-62) 33.6 ± 2.0 2 ± 1 -20.5 -42.5
1.11.47.01. Probable pectinesterase/pectinesterase inhibitor 64 PME64_ARATH Arabidopsis thaliana Plasma memb. In 34-57 (33-63) 35.6 ± 3.0 7 ± 10 -23.3 -25.8
1.11.47.01. Putative pectinesterase 11 PME11_ARATH Arabidopsis thaliana Plasma memb. In 17-35 (12-39) 26.8 ± 4.0 1 ± 2 -8.0 -9.0
1.11.47.01. Probable pectinesterase/pectinesterase inhibitor 13 PME13_ARATH Arabidopsis thaliana Plasma memb. In 25-49 (15-52) 36.4 ± 3.2 0 ± 0 -18.2 -41.7
1.11.47.01. Probable pectinesterase/pectinesterase inhibitor 21 PME21_ARATH Arabidopsis thaliana Plasma memb. In 14-36 (6-41) 34.8 ± 1.0 3 ± 0 -20.0 -22.1
1.11.47.01. Putative pectinesterase/pectinesterase inhibitor 24 PME24_ARATH Arabidopsis thaliana Plasma memb. In 21-48 (16-53) 34.8 ± 4.6 0 ± 0 -22.9 -45.2
1.11.47.01. Putative pectinesterase/pectinesterase inhibitor 26 PME26_ARATH Arabidopsis thaliana Plasma memb. In 30-54 (20-57) 36.0 ± 3.0 4 ± 0 -17.9 -36.9
1.11.47.01. Putative pectinesterase/pectinesterase inhibitor 28 PME28_ARATH Arabidopsis thaliana Plasma memb. In 16-37 (7-42) 33.0 ± 2.0 1 ± 8 -18.8 -20.5
1.11.47.01. Plant invertase/pectin methylesterase inhibitor domain-containing protein F4JCN4_ARATH Arabidopsis thaliana Plasma memb. In 70- 98 (69-101) 36.8 ± 8.0 29 ± 0 -17.4 -23.4
1.11.48.01. Adipocyte plasma membrane-associated protein APMAP_HUMAN Homo sapiens Plasma memb. In 36-62 (34-63) 34.0 ± 2.2 25 ± 13 -13.9 -28.0
1.11.49.01. Fatty-acid amide hydrolase 1 FAAH1_HUMAN Homo sapiens Plasma memb. Out 4-31 (3-37) 33.6 ± 1.2 0 ± 0 -12.8 -26.2
1.11.49.01. Fatty-acid amide hydrolase 2 FAAH2_HUMAN Homo sapiens Plasma memb. Out 9-31 (5-31) 34.6 ± 2.9 6 ± 1 -5.5 -17.0
1.11.49.01. Amidase family protein F4K6N2_ARATH Arabidopsis thaliana Plasma memb. Out 26-47 (22-48) 32.8 ± 2.9 2 ± 2 -10.8 -20.0
1.11.50.01. Endopolyphosphatase PPN1_YEAST Saccharomyces cerevisiae Vacuole memb. In 21-42 (16-42) 30.4 ± 3.7 16 ± 2 -16.4 -24.7
1.11.50.02. Calcineurin-like metallo-phosphoesterase superfamily protein B3H7B7_ARATH Arabidopsis thaliana Membrane Und 356-377 (354-377) 31.6 ± 3.0 17 ± 10 -13.0 -18.4
1.11.50.02. Uncharacterized protein Q54NN5_DICDI Dictyostelium discoideum Membrane Und 20-40 (20-40) 32.6 ± 1.8 8 ± 5 -9.1 -21.9
1.11.50.02. Uncharacterized protein Q54YD1_DICDI Dictyostelium discoideum Membrane Und 5-29 (3-32) 29.6 ± 3.4 31 ± 3 -14.6 -24.0
1.11.50.02. Uncharacterized protein Q54X09_DICDI Dictyostelium discoideum Membrane Und 348-372 (345-375) 30.8 ± 3.0 29 ± 24 -14.2 -19.3
1.11.50.02. Uncharacterized protein C7G010_DICDI Dictyostelium discoideum Membrane Und 344-373 (341-377) 34.0 ± 5.6 47 ± 2 -22.4 -27.3
1.11.50.02. Uncharacterized protein Q54Q65_DICDI Dictyostelium discoideum Membrane Und 364-393 (358-393) 31.6 ± 1.0 49 ± 0 -21.2 -26.1
1.11.50.02. Phosphatase DCR2 DCR2_YEAST Saccharomyces cerevisiae Membrane Und 7-28 (7-29) 31.4 ± 2.9 12 ± 11 -15.9 -21.5
1.11.50.02. Putative metallophosphoesterase YNL217W YNV7_YEAST Saccharomyces cerevisiae Vacuole memb. In 9-31 (2-32) 33.4 ± 2.7 10 ± 0 -18.8 -20.9
1.11.50.03. Probable inactive purple acid phosphatase 2 PPA2_ARATH Arabidopsis thaliana Plasma memb. Out 615-638 (610-642) 30.8 ± 2.6 0 ± 0 -12.8 -40.0
1.11.50.03. Probable inactive purple acid phosphatase 9 PPA9_ARATH Arabidopsis thaliana Plasma memb. Out 602-627 (599-634) 36.4 ± 1.2 0 ± 0 -9.1 -36.1
1.11.50.03. Purple acid phosphatase Q54NC3_DICDI Dictyostelium discoideum Plasma memb. In 9-32 (7-32) 34.8 ± 2.8 7 ± 2 -12.6 -19.5
1.11.50.03. Purple acid phosphatase Q558S4_DICDI Dictyostelium discoideum Plasma memb. Out 540-564 (538-564) 30.4 ± 3.0 0 ± 1 -20.6 -35.1
1.11.50.04. Uncharacterized protein Q54WW5_DICDI Dictyostelium discoideum Membrane Und 336-361 (327-364) 29.6 ± 4.0 43 ± 0 -21.3 -23.7
1.11.51.01. Peroxisomal coenzyme A diphosphatase NUDT7 NUDT7_HUMAN Homo sapiens Peroxisome memb. Und 186-207 (180-207) 31.8 ± 3.5 6 ± 3 -8.9 -16.1
1.11.51.01. Nudix hydrolase 11 NUD11_ARATH Arabidopsis thaliana Peroxisome memb. Und 183-204 (178-207) 28.4 ± 2.1 31 ± 2 -9.5 -18.7
1.11.51.01. Uncharacterized protein Q7KWR0_DICDI Dictyostelium discoideum Membrane Und 320-342 (320-342) 34.2 ± 3.5 12 ± 6 -11.8 -18.7
1.11.51.01. Uncharacterized protein Q54N32_DICDI Dictyostelium discoideum Membrane Und 38-58 (33-60) 29.6 ± 3.6 15 ± 0 -17.3 -23.9
1.11.52.01. AMP deaminase AMPD_ARATH Arabidopsis thaliana Mito. outer memb. Out 5-26 (5-31) 29.2 ± 1.4 0 ± 0 -15.5 -30.7
1.11.53.01. Complement receptor type 1 CR1_HUMAN Homo sapiens Plasma memb. Out 1973-1997 (1970-2000) 32.0 ± 1.6 3 ± 0 -23.3 -53.7
1.11.53.01. Complement receptor type 2 CR2_HUMAN Homo sapiens Plasma memb. Out 973- 999 (973-1004) 32.0 ± 1.6 5 ± 3 -23.1 -43.4
1.11.53.01. Complement decay-accelerating factor DAF_HUMAN Homo sapiens Plasma memb. Out 359-380 (354-380) 31.6 ± 1.6 0 ± 3 -5.5 -29.2
1.11.53.02. Membrane cofactor protein MCP_HUMAN Homo sapiens Plasma memb. Out 344-369 (341-373) 33.6 ± 3.8 23 ± 0 -23.8 -28.2
1.11.53.03. Sushi domain-containing protein 4 SUSD4_HUMAN Homo sapiens Plasma memb. Out 315-347 (312-347) 33.2 ± 3.0 47 ± 0 -22.5 -33.8
1.11.54.01. MANSC domain-containing protein 1 MANS1_HUMAN Homo sapiens Plasma memb. Out 380-412 (380-415) 32.0 ± 1.4 0 ± 3 -23.1 -48.8
1.11.54.01. MANSC domain-containing protein 4 MANS4_HUMAN Homo sapiens Plasma memb. Out 282-306 (275-307) 30.0 ± 2.0 4 ± 1 -12.4 -37.3
1.11.55.01. Kunitz-type protease inhibitor 1 SPIT1_HUMAN Homo sapiens Plasma memb. Out 463-488 (463-492) 34.0 ± 1.6 25 ± 1 -24.0 -29.1
1.11.55.01. Kunitz-type protease inhibitor 2 SPIT2_HUMAN Homo sapiens Plasma memb. Out 196-221 (196-226) 34.8 ± 3.8 20 ± 5 -23.9 -30.5
1.11.56.01. Retinoic acid receptor responder protein 1 TIG1_HUMAN Homo sapiens Vesicle memb. In 21-39 (21-41) 27.2 ± 1.6 15 ± 3 -6.2 -17.5
1.11.57.01. Bcl-2-like protein 1 B2CL1_HUMAN Homo sapiens Mito. outer memb. In 210-231 (201-232) 25.6 ± 2.6 7 ± 4 -9.2 -29.7
1.11.57.01. Bcl-2-like protein 2 B2CL2_HUMAN Homo sapiens Mito. outer memb. In 170-191 (167-192) 28.8 ± 2.6 7 ± 4 -12.5 -30.2
1.11.57.01. Bcl-2-like protein 10 B2L10_HUMAN Homo sapiens Mito. outer memb. In 172-191 (165-193) 28.8 ± 0.6 3 ± 0 -10.1 -32.7
1.11.57.01. Bcl-2-like protein 13 B2L13_HUMAN Homo sapiens Mito. outer memb. In 457-482 (455-484) 29.6 ± 1.6 2 ± 0 -21.8 -33.7
1.11.57.01. Bcl-2 homologous antagonist/killer BAK_HUMAN Homo sapiens Mito. outer memb. In 186-205 (185-206) 30.8 ± 0.0 7 ± 0 -10.1 -25.4
1.11.57.01. Apoptosis regulator BAX BAX_HUMAN Homo sapiens Mito. outer memb. In 170-191 (168-191) 28.0 ± 1.8 1 ± 2 -11.9 -35.9
1.11.57.01. Apoptosis regulator Bcl-2 BCL2_HUMAN Homo sapiens Mito. outer memb. In 214-236 (214-236) 33.6 ± 3.4 2 ± 2 -9.4 -16.7
1.11.57.01. Bcl-2-related ovarian killer protein BOK_HUMAN Homo sapiens ER memb. Und 189-209 (185-209) 15.7 ± 4.0 61 ± 15 -5.7 -15.3
1.11.57.01. Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Homo sapiens Mito. outer memb. In 327-349 (323-349) 22.0 ± 1.8 0 ± 1 -7.1 -19.1
1.11.57.02. Activator of apoptosis harakiri HRK_HUMAN Homo sapiens Mito. outer memb. In 71-88 (68-89) 26.8 ± 1.8 4 ± 2 -8.8 -10.5
1.11.57.03. Bcl-2-interacting killer BIK_HUMAN Homo sapiens Plasma memb. In 133-155 (133-159) 31.2 ± 2.6 32 ± 2 -18.6 -23.4
1.11.58.01. Uncharacterized protein DDB_G0286021 Y8602_DICDI Dictyostelium discoideum Membrane Out 139-171 (136-173) 31.6 ± 6.2 51 ± 10 -15.5 -16.6
1.11.58.01. Uncharacterized protein Q75JG9_DICDI Dictyostelium discoideum Membrane Und 155-175 (150-178) 30.8 ± 4.6 10 ± 11 -10.0 -12.7
1.11.59.01. Receptor-binding cancer antigen expressed on SiSo cells RCAS1_HUMAN Homo sapiens Plasma memb. Out 5-26 (3-29) 20.8 ± 0.8 0 ± 0 -4.4 -15.6
1.11.60.01. Proline-rich membrane anchor 1 PRIMA_HUMAN Homo sapiens Plasma memb. Out 89-118 (86-121) 38.8 ± 4.4 28 ± 2 -25.3 -28.8
1.11.61.01. Tissue factor TF_HUMAN Homo sapiens Plasma memb. Out 248-274 (248-280) 37.2 ± 3.8 23 ± 4 -27.4 -33.3
1.11.63.01. Glioma pathogenesis-related protein 1 GLIP1_HUMAN Homo sapiens Plasma memb. Out 233-255 (229-259) 34.4 ± 2.2 1 ± 1 -17.0 -49.8
1.11.63.01. GLIPR1-like protein 2 GRPL2_HUMAN Homo sapiens Plasma memb. Out 251-276 (251-278) 30.0 ± 2.4 0 ± 1 -14.1 -41.2
1.11.63.01. Peptidase inhibitor 16 PI16_HUMAN Homo sapiens Plasma memb. Out 441-463 (439-463) 33.4 ± 1.6 5 ± 1 -6.9 -20.9
1.11.63.01. Uncharacterized protein Q556Y6_DICDI Dictyostelium discoideum Plasma memb. Out 638-659 (635-659) 33.0 ± 2.8 0 ± 0 -11.4 -19.5
1.11.63.01. Uncharacterized protein Q556T8_DICDI Dictyostelium discoideum Plasma memb. Out 438-457 (434-457) 30.8 ± 2.7 2 ± 1 -9.6 -21.5
1.11.63.01. Uncharacterized protein Q54P01_DICDI Dictyostelium discoideum Plasma memb. Out 738-760 (736-760) 33.8 ± 1.4 2 ± 0 -10.9 -20.4
1.11.63.01. Uncharacterized protein Q54DG5_DICDI Dictyostelium discoideum Plasma memb. Out 315-335 (310-335) 30.2 ± 3.7 5 ± 3 -15.0 -20.7
1.11.63.01. Uncharacterized protein Q8MN43_DICDI Dictyostelium discoideum Plasma memb. Out 442-464 (438-464) 33.6 ± 1.6 2 ± 0 -7.8 -21.4
1.11.63.01. Uncharacterized protein Q86K73_DICDI Dictyostelium discoideum Plasma memb. Out 352-372 (349-372) 31.8 ± 3.1 5 ± 4 -17.7 -25.4
1.11.63.01. Uncharacterized protein Q557J0_DICDI Dictyostelium discoideum Plasma memb. Out 390-410 (386-410) 31.4 ± 3.3 5 ± 3 -10.8 -19.9
1.11.64.01. Lipopolysaccharide assembly protein B LAPB_ECOLI Escherichia coli Gram-neg. inner Out 2-18 (1-24) 29.6 ± 3.8 14 ± 2 -7.7 -22.6
1.11.65.01. Uncharacterized protein MJ0945 Y945_METJA Methanococcus jannaschii Archaebacterial memb. Und 18-40 (18-40) 33.6 ± 2.3 2 ± 2 -7.4 -17.8
1.11.65.02. Expressed protein Q9SLC0_ARATH Arabidopsis thaliana ER memb. Und 169-190 (168-197) 32.0 ± 3.0 3 ± 6 -18.9 -26.1