ZP4_HUMAN » Zona pellucida sperm-binding protein 4

ZP4_HUMAN » Zona pellucida sperm-binding protein 4
Magnify ZP4_HUMAN » Zona pellucida sperm-binding protein 4Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ZP4_HUMAN » Zona pellucida sperm-binding protein 4 » Zona pellucida glycoprotein 4;Zp-4; Zona pellucida protein B;
Hydrophobic Thickness 28.0 ± 1.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -41.2 kcal/mol
ΔGfold -13.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 502-530 (502-532)
Pathways

tRNA charging (BioCyc)

PDB none
OPM none
Complexes none
Interactions

FURIN, Complex: FURIN:ZP4, PubMed

Domains

AA: 143-182, PDBID: 1E9T, Subunit A, Seq Identity:35%, Trefoil (P-type) domain

AA: 189-460, PDBID: 5BUP, Subunit A, Seq Identity:29%, Zona pellucida-like domain

UniProt annotation for ZP4_HUMAN » Zona pellucida sperm-binding protein 4
FUNCTION: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

TISSUE SPECIFICITY: Oocytes.

DOMAIN: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

UniProt features for ZP4_HUMAN » Zona pellucida sperm-binding protein 4
SIGNAL 1 18 Potential.
CHAIN 19 462 Zona pellucida sperm-binding protein 4.
CHAIN 19 ? Processed zona pellucida sperm-binding protein 4.
PROPEP 463 540 Removed in mature form (By similarity).
DOMAIN 141 183 P-type.
DOMAIN 188 466 ZP.
DISULFID 367 442 By similarity.
Amino Acid Sequence for ZP4_HUMAN » Zona pellucida sperm-binding protein 4
MWLLRCVLLC VSLSLAVSGQ HKPEAPDYSS VLHCGPWSFQ FAVNLNQEAT SPPVLIAWDN QGLLHELQND SDCGTWIRKG PGSSVVLEAT YSSCYVTEWD SHYIMPVGVE GAGAAEHKVV TERKLLKCPM DLLARDAPDT DWCDSIPARD RLPCAPSPIS RGDCEGLGCC YSSEEVNSCY YGNTVTLHCT REGHFSIAVS RNVTSPPLLL DSVRLALRND SACNPVMATQ AFVLFQFPFT SCGTTRQITG DRAVYENELV ATRDVKNGSR GSVTRDSIFR LHVSCSYSVS SNSLPINVQV FTLPPPFPET QPGPLTLELQ IAKDKNYGSY YGVGDYPVVK LLRDPIYVEV SILHRTDPYL GLLLQQCWAT PSTDPLSQPQ WPILVKGCPY IGDNYQTQLI PVQKALDLPF PSHHQRFSIF TFSFVNPTVE KQALRGPVHL HCSVSVCQPA ETPSCVVTCP DLSRRRNFDN SSQNTTASVS SKGPMILLQA TKDPPEKLRV PVDSKVLWVA GLSGTLILGA LLVSYLAVKK QKSCPDQMCQ