ZP3_HUMAN » Zona pellucida sperm-binding protein 3

ZP3_HUMAN » Zona pellucida sperm-binding protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ZP3_HUMAN » Zona pellucida sperm-binding protein 3 » Sperm receptor;ZP3A/ZP3B;Zona pellucida glycoprotein 3;Zp-3; Zona pellucida protein C;
Hydrophobic Thickness 37.6 ± 1.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -56.4 kcal/mol
ΔGfold -21.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 385-413 (382-416)
Pathways none
PDB none
OPM none
Complexes

ZP3:ZP3_MOUSE

Interactions

FURIN, Complex: ZP3:FURIN, PubMed

PCD17, Complex: PCD17:ZP3, PubMed

SACA3, Complex: SACA3:ZP3, PubMed

ZP3, Complex: Homodimer of zona pellucida sperm-binding protein 3, PDBID: 3EF7

Domains

AA: 46-301, PDBID: 3D4C, Subunit A, Seq Identity:70%, Zona pellucida-like domain

UniProt annotation for ZP3_HUMAN » Zona pellucida sperm-binding protein 3
FUNCTION: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

SUBUNIT: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

TISSUE SPECIFICITY: Oocytes.

DOMAIN: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

UniProt features for ZP3_HUMAN » Zona pellucida sperm-binding protein 3
SIGNAL 1 22
CHAIN 23 350 Zona pellucida sperm-binding protein 3.
CHAIN 23 ? Processed zona pellucida sperm-binding protein 3.
PROPEP 351 424 Removed in mature form (By similarity).
DOMAIN 45 307 ZP.
DISULFID 46 140
DISULFID 78 99
DISULFID 217 282
DISULFID 239 300
Amino Acid Sequence for ZP3_HUMAN » Zona pellucida sperm-binding protein 3
MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV SASE