ZP1_HUMAN » Zona pellucida sperm-binding protein 1

ZP1_HUMAN » Zona pellucida sperm-binding protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ZP1_HUMAN » Zona pellucida sperm-binding protein 1 » Zona pellucida glycoprotein 1;Zp-1;
Hydrophobic Thickness 36.0 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -40.3 kcal/mol
ΔGfold -19.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 601-626 (601-631)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 280-547, PDBID: 3NK3, Subunit B, Seq Identity:22%, Zona pellucida-like domain

UniProt annotation for ZP1_HUMAN » Zona pellucida sperm-binding protein 1
FUNCTION: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

SUBUNIT: Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

TISSUE SPECIFICITY: Oocytes.

DOMAIN: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

DISEASE: Oocyte maturation defect (OOMD) OMIM: An infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa. caused by mutations affecting the gene represented in this entry.

UniProt features for ZP1_HUMAN » Zona pellucida sperm-binding protein 1
SIGNAL 1 25 Potential.
CHAIN 26 553 Zona pellucida sperm-binding protein 1.
CHAIN 26 ? Processed zona pellucida sperm-binding protein 1.
PROPEP 554 638 Removed in mature form (By similarity).
DOMAIN 234 274 P-type.
DOMAIN 279 553 ZP.
DISULFID 457 478 By similarity.
Amino Acid Sequence for ZP1_HUMAN » Zona pellucida sperm-binding protein 1
MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL LVFPRPGQTL RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG CHVLEKDGRF HLRVFMEAVL PNGRVDVAQD ATLICPKPDP SRTLDSQLAP PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP SPLDPGHSSV HPTPALPSPG PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS GHLPCIVRRT SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL VSGIHIQKGP QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT QPGPLRLELR IAKDETFSSY YGEDDYPIVR LLREPVHVEV RLLQRTDPNL VLLLHQCWGA PSANPFQQPQ WPILSDGCPF KGDSYRTQMV ALDGATPFQS HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE TCSTACSTGT TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ