ZFPL1_HUMAN » Zinc finger protein-like 1

ZFPL1_HUMAN » Zinc finger protein-like 1
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
ZFPL1_HUMAN » Zinc finger protein-like 1 » Zinc finger protein MCG4;
Hydrophobic Thickness 30.8 ± 3.6 Å
Tilt Angle 28 ± 0°
ΔGtransfer -24.6 kcal/mol
ΔGfold -18.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 261-286 (261-291)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ATPK, Complex: ZFPL1:ATPK, PubMed

Domains none
UniProt annotation for ZFPL1_HUMAN » Zinc finger protein-like 1
FUNCTION: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

SUBUNIT: Interacts with GOLGA2/GM130.

TISSUE SPECIFICITY: Expressed strongly in the exocrine pancreas.

DOMAIN: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.

UniProt features for ZFPL1_HUMAN » Zinc finger protein-like 1
CHAIN 1 310 Zinc finger protein-like 1.
ZN_FING 1 43 B box-type; degenerate.
ZN_FING 53 101 RING-type; degenerate.
Amino Acid Sequence for ZFPL1_HUMAN » Zinc finger protein-like 1
MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN PNCRLCNIPL ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC NGPIFPPTNL AGPVASALRE KLATVNWARA GLGLPLIDEV VSPEPEPLNT SDFSDWSSFN ASSTPGPEEV DSASAAPAFY SQAPRPPASP GRPEQHTVIH MGNPEPLTHA PRKVYDTRDD DRTPGLHGDC DDDKYRRRPA LGWLARLLRS RAGSRKRPLT LLQRAGLLLL LGLLGFLALL ALMSRLGRAA ADSDPNLDPL MNPHIRVGPS