YMEL1_HUMAN » ATP-dependent zinc metalloprotease YME1L1

YMEL1_HUMAN » ATP-dependent zinc metalloprotease YME1L1
Magnify YMEL1_HUMAN » ATP-dependent zinc metalloprotease YME1L1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
YMEL1_HUMAN » ATP-dependent zinc metalloprotease YME1L1 » ATP-dependent metalloprotease FtsH1;Meg-4;Presenilin-associated metalloprotease;PAMP; YME1-like protein 1;
Hydrophobic Thickness 28.6 ± 2.5 Å
Tilt Angle 1 ± 0°
ΔGtransfer -20.4 kcal/mol
ΔGfold -12.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 292-310 (287-310)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FKBP8, Complex: FKBP8:YMEL1, PubMed

NDUB6, Complex: NDUB6:YMEL1

Domains

AA: 375-506, PDBID: 2CE7, Subunit D, Seq Identity:77%, ATPase family associated with various cellular activities (AAA)

AA: 566-764, PDBID: 1LV7, Subunit A, Seq Identity:45%, Peptidase family M41

UniProt annotation for YMEL1_HUMAN » ATP-dependent zinc metalloprotease YME1L1
FUNCTION: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1.

SUBUNIT: Exists in several complexes of 600-1100 kDa.

TISSUE SPECIFICITY: High expression in cardiac and skeletal muscle mitochondria.

UniProt features for YMEL1_HUMAN » ATP-dependent zinc metalloprotease YME1L1
CHAIN 1 773 ATP-dependent zinc metalloprotease YME1L1.
ACT_SITE 600 600 By similarity.
Amino Acid Sequence for YMEL1_HUMAN » ATP-dependent zinc metalloprotease YME1L1
MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH EAPSSECMFS DFLTKLNIVS IGKGKIFEGY RSMFMEPAKR MKKSLDTTDN WHIRPEPFSL SIPPSLNLRD LGLSELKIGQ IDQLVENLLP GFCKGKNISS HWHTSHVSAQ SFFENKYGNL DIFSTLRSSC LYRHHSRALQ SICSDLQYWP VFIQSRGFKT LKSRTRRLQS TSERLAETQN IAPSFVKGFL LRDRGSDVES LDKLMKTKNI PEAHQDAFKT GFAEGFLKAQ ALTQKTNDSL RRTRLILFVL LLFGIYGLLK NPFLSVRFRT TTGLDSAVDP VQMKNVTFEH VKGVEEAKQE LQEVVEFLKN PQKFTILGGK LPKGILLVGP PGTGKTLLAR AVAGEADVPF YYASGSEFDE MFVGVGASRI RNLFREAKAN APCVIFIDEL DSVGGKRIES PMHPYSRQTI NQLLAEMDGF KPNEGVIIIG ATNFPEALDN ALIRPGRFDM QVTVPRPDVK GRTEILKWYL NKIKFDQSVD PEIIARGTVG FSGAELENLV NQAALKAAVD GKEMVTMKEL EFSKDKILMG PERRSVEIDN KNKTITAYHE SGHAIIAYYT KDAMPINKAT IMPRGPTLGH VSLLPENDRW NETRAQLLAQ MDVSMGGRVA EELIFGTDHI TTGASSDFDN ATKIAKRMVT KFGMSEKLGV MTYSDTGKLS PETQSAIEQE IRILLRDSYE RAKHILKTHA KEHKNLAEAL LTYETLDAKE IQIVLEGKKL EVR