YME1_YEAST » Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1

YME1_YEAST » Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
YME1_YEAST » Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1 » Protein OSD1;Tat-binding homolog 11;Yeast mitochondrial escape protein 1;
Hydrophobic Thickness 28.6 ± 1.5 Å
Tilt Angle 17 ± 0°
ΔGtransfer -17.7 kcal/mol
ΔGfold -3.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 227-248 (224-249)
Pathways none
PDB 2mv3 (A=97-176)
OPM none
Complexes none
Interactions none
Domains

AA: 317-447, PDBID: 2CE7, Subunit D, Seq Identity:71%, ATPase family associated with various cellular activities (AAA)

AA: 507-706, PDBID: 1LV7, Subunit A, Seq Identity:45%, Peptidase family M41

UniProt annotation for YME1_YEAST » Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
FUNCTION: Catalytic subunit of the mitochondrial inner membrane i- AAA protease supercomplex required for mitochondrial inner membrane protein turnover. The protease is probably ATP-dependent. Important to maintain the integrity of the mitochondrial compartment. Required both for the degradation of unassembled subunit 2 of cytochrome c oxidase (COX2) and for efficient assembly of mitochondrial respiratory chain. Binds unfolded substrates in an ATPase-independent manner; binding of folded COX2, a physiological substrate, requires an active ATPase but when COX2 is destabilized an active ATPase is no longer necessary.
UniProt features for YME1_YEAST » Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
CHAIN 1 747 Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1.

ACT_SITE 541 541

Amino Acid Sequence for YME1_YEAST » Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
MNVSKILVSP TVTTNVLRIF APRLPQIGAS LLVQKKWALR SKKFYRFYSE KNSGEMPPKK EADSSGKASN KSTISSIDNS QPPPPSNTND KTKQANVAVS HAMLATREQE ANKDLTSPDA QAAFYKLLLQ SNYPQYVVSR FETPGIASSP ECMELYMEAL QRIGRHSEAD AVRQNLLTAS SAGAVNPSLA SSSSNQSGYH GNFPSMYSPL YGSRKEPLHV VVSESTFTVV SRWVKWLLVF GILTYSFSEG FKYITENTTL LKSSEVADKS VDVAKTNVKF DDVCGCDEAR AELEEIVDFL KDPTKYESLG GKLPKGVLLT GPPGTGKTLL ARATAGEAGV DFFFMSGSEF DEVYVGVGAK RIRDLFAQAR SRAPAIIFID ELDAIGGKRN PKDQAYAKQT LNQLLVELDG FSQTSGIIII GATNFPEALD KALTRPGRFD KVVNVDLPDV RGRADILKHH MKKITLADNV DPTIIARGTP GLSGAELANL VNQAAVYACQ KNAVSVDMSH FEWAKDKILM GAERKTMVLT DAARKATAFH EAGHAIMAKY TNGATPLYKA TILPRGRALG ITFQLPEMDK VDITKRECQA RLDVCMGGKI AEELIYGKDN TTSGCGSDLQ SATGTARAMV TQYGMSDDVG PVNLSENWES WSNKIRDIAD NEVIELLKDS EERARRLLTK KNVELHRLAQ GLIEYETLDA HEIEQVCKGE KLDKLKTSTN TVVEGPDSDE RKDIGDDKPK IPTMLNA