X3CL1_HUMAN » Fractalkine

X3CL1_HUMAN » Fractalkine
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
X3CL1_HUMAN » Fractalkine » C-X3-C motif chemokine 1;CX3C membrane-anchored chemokine;Neurotactin;Small-inducible cytokine D1;
Hydrophobic Thickness 34.6 ± 1.1 Å
Tilt Angle 1 ± 0°
ΔGtransfer -23.6 kcal/mol
ΔGfold -18.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 341-363 (333-366)
Pathways

Chemokine signaling pathway (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Signal Transduction (Reactome)

TNF signaling pathway (KEGG)

PDB 1b2t (25-100), 1f2l (A/B/C/D=25-98), 3ona (B=24-100), 4xt1 (B=26-101), 4xt3 (B=26-101)
OPM 4xt1, 4xt3
Complexes

US28:X3CL1_HUMAN

X3CL1:X3CL1_HUMAN

Interactions

X3CL1, Complex: Homodimer of fractalkine, PDBID: 1F2L

Domains

AA: 31-89, PDBID: 1B2T, Subunit A, Seq Identity:100%, Small cytokines (intecrine/chemokine), interleukin-8 like

UniProt annotation for X3CL1_HUMAN » Fractalkine
FUNCTION: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.

SUBUNIT: Monomer. Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1.

TISSUE SPECIFICITY: Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.

INDUCTION: By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells.

UniProt features for X3CL1_HUMAN » Fractalkine
SIGNAL 1 24
CHAIN 25 397 Fractalkine.
CHAIN 25 ?339 Processed fractalkine.
REGION 25 100 Chemokine.
REGION 101 341 Mucin-like stalk.
SITE 339 340 Cleavage; to produce soluble form (Potential).
DISULFID 32 58
DISULFID 36 74
Amino Acid Sequence for X3CL1_HUMAN » Fractalkine
MAPISLSWLL RLATFCHLTV LLAGQHHGVT KCNITCSKMT SKIPVALLIH YQQNQASCGK RAIILETRQH RLFCADPKEQ WVKDAMQHLD RQAAALTRNG GTFEKQIGEV KPRTTPAAGG MDESVVLEPE ATGESSSLEP TPSSQEAQRA LGTSPELPTG VTGSSGTRLP PTPKAQDGGP VGTELFRVPP VSTAATWQSS APHQPGPSLW AEAKTSEAPS TQDPSTQAST ASSPAPEENA PSEGQRVWGQ GQSPRPENSL EREEMGPVPA HTDAFQDWGP GSMAHVSVVP VSSEGTPSRE PVASGSWTPK AEEPIHATMD PQRLGVLITP VPDAQAATRR QAVGLLAFLG LLFCLGVAMF TYQSLQGCPR KMAGEMAEGL RYIPRSCGSN SYVLVPV