WIT2_ARATH » WPP domain-interacting tail-anchored protein 2

WIT2_ARATH » WPP domain-interacting tail-anchored protein 2
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
WIT2_ARATH » WPP domain-interacting tail-anchored protein 2 »
Hydrophobic Thickness 30.4 ± 4.0 Å
Tilt Angle 22 ± 5°
ΔGtransfer -24.7 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 605-626 (598-627)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for WIT2_ARATH » WPP domain-interacting tail-anchored protein 2
FUNCTION: Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips.

SUBUNIT: Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3.

TISSUE SPECIFICITY: Ubiquitous.

UniProt features for WIT2_ARATH » WPP domain-interacting tail-anchored protein 2
CHAIN 1 627 WPP domain-interacting tail-anchored protein 2.
COILED 81 152 Potential.
COILED 188 218 Potential.
COILED 312 542 Potential.
Amino Acid Sequence for WIT2_ARATH » WPP domain-interacting tail-anchored protein 2
MEEIIREDYF EALSSRNEEE QEMLRMLTKL EIDSAYTSEK LMNLHVLLMH LLAWDNDLEG MGTLDSSPAS FEKALTFDLL CGILESEVKE VDEVLDVLEA QIVDTSYKIS SCKHGNYIVI EGKLGESAES LKQSRGQVSE ITLQLAQLRR TLHYIRNGTS ENEESVELRQ KYALKPSDLR HKNALRMLEK SLSRELELEK KLMEFQQNEE QLKLKLHYTE EVSSRMEEAS EFIWGRFLEA DNSSEVLTGI SKELVGRLQI LQFSLNGSAQ RESELKSKLE DCTVQLEAKD LLVQKLEGTI SENSEIVSEV LTLREYVKSA EQKLKNTDLE LKSVNASKQE ILVHLAEMEN ANESVKENLF EAESRAESGE AKIKELDAAN LELTEELNFL KDADDKKTKK VNSLEKQVRE LEVQVQNSKV SSEANQEQQN MLYSAIWDME TLIEDLKSKA SKAESRTETV EEQCIVLSTT NSELNKDVSF LRQKAKSLEA MLDLANNEKE RYAQEITTRN KVLMDMMLQL SSERERIQEQ LYSLAKENKI LRVNQCSNTY QRNGSYAGDK ELSFHADGHE IEALAESLQE DERTREEPEK QSVSEKSSEI RRAIKLKHIL VVALVFVLFC SFFGVTY