WIT1_ARATH » WPP domain-interacting tail-anchored protein 1

WIT1_ARATH » WPP domain-interacting tail-anchored protein 1
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
WIT1_ARATH » WPP domain-interacting tail-anchored protein 1 »
Hydrophobic Thickness 30.0 ± 2.0 Å
Tilt Angle 0 ± 4°
ΔGtransfer -20.6 kcal/mol
ΔGfold -18.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 678-698 (674-700)
Pathways none
PDB none
OPM none
Complexes none
Interactions

WIP1, Complex: WIP1:WIT1

WIP2, Complex: WIP2:WIT1, PubMed

Domains none
UniProt annotation for WIT1_ARATH » WPP domain-interacting tail-anchored protein 1
FUNCTION: Together with WIT2, required for the nuclear envelope docking of RANGAP proteins in root tips.

SUBUNIT: Homodimer. Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3. Interacts with WIP2, WPP1/MAF1, WPP2/MAF2, RANGAP1 and RANGAP2. Component of a ternary complex composed of WPP1, HSP70-1 and WIT1.

TISSUE SPECIFICITY: Ubiquitous.

UniProt features for WIT1_ARATH » WPP domain-interacting tail-anchored protein 1
CHAIN 1 703 WPP domain-interacting tail-anchored protein 1.
COILED 118 183 Potential.
COILED 236 265 Potential.
COILED 318 461 Potential.
COILED 500 604 Potential.
Amino Acid Sequence for WIT1_ARATH » WPP domain-interacting tail-anchored protein 1
METETEHDRT VSVDDNDSLV PEPSSTKESF FEDLSLTGQV MNPQLSSAGE VLTKVELDFA FVSEKLVNLS LLTMQLGTRE NDFESFVSKK EEDEEEPSSN VDDDDDSAEK ALEFDLLSSI LNSEVKELES LLGFLQNEIQ SARVMISPFQ HDGEAFLDLE GKLNDTEQSL GQLMEQVVEM KKQSSNFQRL SSGLDEQGSW SGGQTSVSQN DGEFGDLSAK INMQTADQQR NVLRMLEKSL AKEMELEKKL SESRNTEREL EMKLYSSEQD VVYMEEVTED AFSRWLEADN AAEVFKGTSK EMSGKLQILQ FNLSGSFKRE DNLKSKLVDS KERLEAKECA LHKLDSSNAR LADFLVAQTE GLKESLQEAE EKLILLNTEN STLSEKVSSL EEQLNEYGIQ TEDADATSGA LITDLERINE ELKDKLAKTE ARAEETESKC KILEESKKEL QDELGNFRDK GFTIHKLASL EKHLRDSDLQ LEHAVAAVEA SKEKQNLLYS TVSDMEDVIE DLKSKVLKAE NRADITEEKL IMVSESNAEV NEELKFFKGR LKEGEKYLQQ AEERKLRTAK DIGVHNKIMK KLVMQLAAER ERLHKQITNL SRENCVLMVK LKKVGKTGYM ESGNGSEVSP KSDQNASSCH QGSRLQATFI SLTNPEEEET GSKSDIGSVR RLDVGALRFK HILVAILVIL ISSIAYVISQ QNM