WIP3_ARATH » WPP domain-interacting protein 3

WIP3_ARATH » WPP domain-interacting protein 3
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
WIP3_ARATH » WPP domain-interacting protein 3 »
Hydrophobic Thickness 30.8 ± 2.8 Å
Tilt Angle 29 ± 7°
ΔGtransfer -21.9 kcal/mol
ΔGfold -11.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 427-449 (423-450)
Pathways none
PDB none
OPM none
Complexes none
Interactions

WIP1, Complex: WIP1:WIP3

Domains none
UniProt annotation for WIP3_ARATH » WPP domain-interacting protein 3
FUNCTION: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips.

SUBUNIT: Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3 (By similarity). Interacts with RANGAP1, WPP1/MAF1, and WPP2/MAF2 (PubMed). Interacts with SUN1 and SUN2 (PubMed). Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane WIP proteins, the nucleoskeletal CRWN/LINC proteins, and, possibly, KAKU4 (Probable).

TISSUE SPECIFICITY: Expressed in seedlings, roots, stems, leaves, and flowers.

DEVELOPMENTAL STAGE: First observed in roots and cotyledons of young developing seedlings. Later confined to root tips and cauline leaves tips. In flowers, detected in the stamens and at the senescence region of developing siliques.

UniProt features for WIP3_ARATH » WPP domain-interacting protein 3
CHAIN 1 459 WPP domain-interacting protein 3.
COILED 331 375 Potential.
MOTIF 60 61 Nuclear localization signal 1 (By similarity).
MOTIF 63 64 Nuclear localization signal 2 (By similarity).
MOTIF 86 87 Nuclear localization signal 3 (By similarity).
Amino Acid Sequence for WIP3_ARATH » WPP domain-interacting protein 3
MNESVPDSVE DNGNSVPANG LLVLPDNDHE EGGVGSPQRS NSVESPGGSV HSTRKGFGLK KWRRIKRDGP VRDEAAPVDD GSKLLKRGLA GLVNPPSKHV EFSSVEARQS SEGSVGSVNM VHHPGVANGF SPDIGCMFAV GQAFEKSEEH SGNTIGGKNV VGGKVVSGSQ EKLWSDTIKR ASEERGDIEK EKPCSSLDSD LRSSDFVFST GSVSVGNHGE KDERLTMNYI GGFSNEGQVK EEVQTYSRSE NGNKEDDGES KKNNNHWADK DALADSIRSF AVLQEVLWKE VQSFQELGKE SVLLHSNTDE LSSDQPSHQN CKEDNSTSSG SKALILKEKV KLLEHKLEEA RAALEAKEAR IQELENSKIE SELECIFQRK IETEIEHLML TRSLSSLQVL QETKKLHSLK EDPVSNRGNI LGKTCKLGFY ILTQLILLVS ILRFLVLQFS PASRLVIPT