WIP2_ARATH » WPP domain-interacting protein 2

WIP2_ARATH » WPP domain-interacting protein 2
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
WIP2_ARATH » WPP domain-interacting protein 2 »
Hydrophobic Thickness 24.8 ± 0.4 Å
Tilt Angle 2 ± 0°
ΔGtransfer -27.8 kcal/mol
ΔGfold -9.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 478-499 (470-500)
Pathways none
PDB none
OPM none
Complexes none
Interactions

WIT1, Complex: WIP2:WIT1, PubMed

Domains none
UniProt annotation for WIP2_ARATH » WPP domain-interacting protein 2
FUNCTION: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips.

SUBUNIT: Homodimer, and heterodimer with WIP1. Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3. Interacts with RANGAP1, RANGAP2, WIT1, WPP1/MAF1, and WPP2/MAF2 (PubMed, PubMed). Interacts with SUN1 and SUN2 (PubMed). Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane WIP proteins, the nucleoskeletal CRWN/LINC proteins, and, possibly, KAKU4 (Probable).

TISSUE SPECIFICITY: Expressed in seedlings, roots, stems, leaves, and flowers.

DEVELOPMENTAL STAGE: First observed in roots and cotyledons of young developing seedlings. Later confined to root tips and vascular tissue around the shoot apex. In flowers, detected in the stamens and at the senescence region of developing siliques.

UniProt features for WIP2_ARATH » WPP domain-interacting protein 2
CHAIN 1 509 WPP domain-interacting protein 2.
COILED 277 302 Potential.
COILED 340 389 Potential.
COILED 431 470 Potential.
MOTIF 44 45 Nuclear localization signal 1 (By similarity).
MOTIF 47 48 Nuclear localization signal 2 (By similarity).
MOTIF 70 71 Nuclear localization signal 3 (By similarity).
Amino Acid Sequence for WIP2_ARATH » WPP domain-interacting protein 2
MDLESESSVL ESVEDNNGLI GDLDKELNSP VETSPLISKG FGLRKWKRRL RRDLVKDDTS VSMENSKALK RVLSGLVDPN AKQMHLPGPE VRQDSVGSVG SVNSVVGFVM GGESYGNGLA FAAGVDSDNS EDRSSTMSHS WDKHRGKVSG GKSVISSGDS SQQRKSSVEK SNKLRGERIK IEKENSHSSM ESADSRSSNF VFMQGASYSL SSREQGGRRM MDYDDENSDH DAHTSKRKDN VEEEEEETED YSQGDCVEES QIKSNGSSDN LDPLIVAVNS FQTLQEALQK ELQKFQELGK EEPITSLHDG GESSSCIHAG HEGASEASSS YRFGSEKMGE MELTSLDSEI LNLVNNVEHL EIKLEEAKRI LEVKETQIRE LESTINVSET CNGGTEIGIE DIFQQKVEAE IEYIIFSRSV GNLKRRIKLI EEEKTLGLSK LDKAETKAEN LKNQAQDLQN HCVEITEIQE VECLKKRAFK TTRCLLLQLG LLFILYYSLL PEPEIAVPT