WIP1_ARATH » WPP domain-interacting protein 1

WIP1_ARATH » WPP domain-interacting protein 1
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
WIP1_ARATH » WPP domain-interacting protein 1 »
Hydrophobic Thickness 30.0 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -35.9 kcal/mol
ΔGfold -16.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 459-480 (459-480)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BET11, Complex: BET11:WIP1, PubMed

CYB5E, Complex: CYB5E:WIP1, PubMed

FIS1B, Complex: FIS1B:WIP1, PubMed

GXM3, Complex: GXM3:WIP1, PubMed

IX15L, Complex: IX15L:WIP1, PubMed

SYP51, Complex: SYP51:WIP1, PubMed

SYP61, Complex: SYP61:WIP1, PubMed

TO203, Complex: TO203:WIP1, PubMed

VA722, Complex: VA722:WIP1, PubMed

VAP11, Complex: VAP11:WIP1, PubMed

VTI11, Complex: VTI11:WIP1, PubMed

WIP2, Complex: WIP1:WIP2

WIP3, Complex: WIP1:WIP3

Domains none
UniProt annotation for WIP1_ARATH » WPP domain-interacting protein 1
FUNCTION: Mediates and enhances the nuclear envelope docking of RANGAP proteins mediated by WIT1 and WIT2 in the undifferentiated cells of root tips.

SUBUNIT: Homodimer and heterodimer with WIP2. Component of Ran complexes at least composed of WIT1 or WIT2, RANGAP1 or RANGAP2, and WIP1 or WIP2 or WIP3. Interacts with RANGAP1, RANGAP2, WPP1/MAF1, and WPP2/MAF2 (PubMed, PubMed). Interacts with SUN1 and SUN2 (PubMed). Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane WIP proteins, the nucleoskeletal CRWN/LINC proteins, and, possibly, KAKU4 (Probable).

TISSUE SPECIFICITY: Expressed in seedlings, roots, stems, leaves, and flowers.

DEVELOPMENTAL STAGE: First observed in roots and cotyledons of young developing seedlings. Later confined to root tips, vascular tissue around the shoot apex, and in young leaf primodia. In flowers, detected in the stamens and at the senescence region of developing siliques.

UniProt features for WIP1_ARATH » WPP domain-interacting protein 1
CHAIN 1 489 WPP domain-interacting protein 1.
COILED 323 446 Potential.
MOTIF 80 81 Nuclear localization signal 1.
MOTIF 83 84 Nuclear localization signal 2.
MOTIF 104 105 Nuclear localization signal 3.
Amino Acid Sequence for WIP1_ARATH » WPP domain-interacting protein 1
MDLESESSAL ESVDDNVLIQ QSASNVCDDG RSLDNGSCSD ESVKLLSTSN SVELGKPMSF DSPGDGGGAY SPVLKGQGLR KWRRIRRDLV KDTSANMENS KALKRGLSGV AHSHGKQMQF QSPEVEQESQ GSVGSVNMLK SSGDGFDILG SSGYDSRFVA GVGFSAGMDL EIDDDRSSKS STVARAPKVI RYEKPMISSG QGGNIRVENS KKHRGESVDF EKENSYSSLE SDSRKQSGRM MDYNGENGET SMRKDDAGGE GGESINTDNR YSDEMDPLTE AINGFLALQD ALEKEVQQFQ EIGNEPMPQH HEQVSEANSP HPEIVTLVNN VEQLENMLEE TRSMLEVKES HIRDLESTTN QSKHSWGGTE IVVEDIFRQK IEAEIEYLIY SRSIDNLNSQ MKLIDEQESL AEEQTHETLN KLGRVQTKAA NFTNRAQDLQ NDCIEITGTI KKRACKITSY VLIQLVLLST VVLLLLSQLL PEPDTVVPT