WAKLI_ARATH » Wall-associated receptor kinase-like 22

WAKLI_ARATH » Wall-associated receptor kinase-like 22
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
WAKLI_ARATH » Wall-associated receptor kinase-like 22 »
Hydrophobic Thickness 30.4 ± 3.8 Å
Tilt Angle 0 ± 3°
ΔGtransfer -50.4 kcal/mol
ΔGfold -16.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 347-371 (347-375)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BETL2, Complex: WAKLI:BETL2

PAM74, Complex: WAKLI:PAM74

UBC34, Complex: WAKLI:UBC34

WAK3, Complex: WAKLI:WAK3

Domains

AA: 34-148, Wall-associated receptor kinase galacturonan-binding

AA: 174-279, Wall-associated kinase

AA: 421-690, PDBID: 3TL8, Subunit A, Seq Identity:49%, Protein kinase domain

UniProt annotation for WAKLI_ARATH » Wall-associated receptor kinase-like 22
FUNCTION: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Required during plant"s response to pathogen infection.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

DOMAIN: The EGF-like region is specific to this family of proteins and seems to consist of the C-terminal of an EGF-like domain fused to the N-terminal of another one.

UniProt features for WAKLI_ARATH » Wall-associated receptor kinase-like 22
SIGNAL 1 27 Potential.
CHAIN 28 751 Wall-associated receptor kinase-like 22.
DOMAIN 421 694 Protein kinase.
REGION 275 336 Atypical EGF-like.
ACT_SITE 546 546 Proton acceptor (By similarity).
DISULFID 277 290 By similarity.
DISULFID 313 327 By similarity.
DISULFID 322 336 By similarity.
Amino Acid Sequence for WAKLI_ARATH » Wall-associated receptor kinase-like 22
MKRRRLFFSV LLSILTLFIN GPLITTAQSP PSSSTSCNRI CGGIEIPFPF GIGRRDCFLN DWYEVVCNST TSGKSLAPFL YKINRELVSI TLRSSIDSSY GVVHIKSPVT SSGCSQRPVK PLPLNLTGKG SPFFITDSNR LVSVGCDNRA LITDIESQIT GCESSCDGDK SRLDKICGGY TCCQAKIPAD RPQVIGVDLE SSGGNTTQGG NCKVAFLTNE TYSPANVTEP EQFYTNGFTV IELGWYFDTS DSRLTNPVGC VNLTETGIYT SAPSCVCEYG NFSGFGYSNC YCNQIGYRGN PYLPGGCIDI DECEEGKGLS SCGELTCVNV PGSWRCELNG VGKIKPLFPG LVLGFPLLFL VLGIWGLIKF VKKRRKIIRK RMFFKRNGGL LLKQQLTTRG GNVQSSKIFS SKELEKATDN FNMNRVLGQG GQGTVYKGML VDGRIVAVKR SKVLDEDKVE EFINEVGVLS QINHRNIVKL MGCCLETEVP ILVYEHIPNG DLFKRLHHDS DDYTMTWDVR LRISVEIAGA LAYLHSAAST PVYHRDVKTT NILLDEKYRA KVSDFGTSRS INVDQTHLTT LVAGTFGYLD PEYFQTSQFT DKSDVYSFGV VLVELITGEK PFSVMRPEEN RGLVSHFNEA MKQNRVLDIV DSRIKEGCTL EQVLAVAKLA RRCLSLKGKK RPNMREVSVE LERIRSSPED LELHIEEEDE EECAMEINMD DSWSVDMTAP ASLFDLSPKL DVEPLVPQRT W