WAKLG_ARATH » Wall-associated receptor kinase-like 8

WAKLG_ARATH » Wall-associated receptor kinase-like 8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
WAKLG_ARATH » Wall-associated receptor kinase-like 8 »
Hydrophobic Thickness 31.4 ± 4.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -18.2 kcal/mol
ΔGfold -13.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 318-339 (314-343)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BET12, Complex: WAKLG:BET12

BETL2, Complex: WAKLG:BETL2

CRK40, Complex: WAKLG:CRK40

PAM74, Complex: WAKLG:PAM74

UBC34, Complex: WAKLG:UBC34

WAK3, Complex: WAKLG:WAK3

Domains

AA: 30-142, Wall-associated receptor kinase galacturonan-binding

AA: 171-270, Wall-associated kinase

AA: 390-660, PDBID: 3OMV, Subunit A, Seq Identity:42%, Protein tyrosine kinase

UniProt annotation for WAKLG_ARATH » Wall-associated receptor kinase-like 8
FUNCTION: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

DOMAIN: The EGF-like region is specific to this family of proteins and seems to consist of the C-terminal of an EGF-like domain fused to the N-terminal of another one.

UniProt features for WAKLG_ARATH » Wall-associated receptor kinase-like 8
SIGNAL 1 23 Potential.
CHAIN 24 720 Wall-associated receptor kinase-like 8.
DOMAIN 390 663 Protein kinase.
REGION 252 310 Atypical EGF-like.
ACT_SITE 515 515 Proton acceptor (By similarity).
DISULFID 254 266 By similarity.
DISULFID 288 301 By similarity.
DISULFID 296 310 By similarity.
Amino Acid Sequence for WAKLG_ARATH » Wall-associated receptor kinase-like 8
MGVDVKRFLV VMLLLRICEY AAASTFPLAL RNCSDHCGNV SVPYPFGIGK GCYKNKWFEI VCKSSSDQQP ILLLPRIRRA VTSFNLGDPF SISVYNKFYI QSPLKHSGCP NRDGYSSSSL NLKGSPFFIS ENNKFTAVGC NNKAFMNVTG LQIVGCETTC GNEIRSYKGA NTSCVGYKCC QMTIPPLLQL QVFDATVEKL EPNKQGCQVA FLTQFTLSGS LFTPPELMEY SEYTTIELEW RLDLSYMTSK RVLCKGNTFF EDSYQCSCHN GYEGNPYIPG GCQDIDECRD PHLNKCGKRK CVNVLGSYRC EKTWPAILSG TLSSGLLLLI FGMWLLCKAN RKRKVAKQKR KFFQRNGGLL LQQQTSFLHG SVNRTKVFSS NDLENATDRF NASRILGQGG QGTVYKGMLE DGMIVAVKKS KALKEENLEE FINEIILLSQ INHRNVVKIL GCCLETEVPI LVYEFIPNRN LFDHLHNPSE DFPMSWEVRL CIACEVADAL SYLHSAVSIP IYHRDVKSTN ILLDEKHRAK VSDFGISRSV AIDDTHLTTI VQGTIGYVDP EYLQSNHFTG KSDVYSFGVL LIELLTGEKP VSLLRRQEVR MLGAYFLEAM RNDRLHEILD ARIKEECDRE EVLAVAKLAR RCLSLNSEHR PTMRDVFIEL DRMQSKRKGT QSQAQNGEEH AHIQIAMPES MSLSYSSPNI VVENSSFSLD TKPLMPHKTQ