WAK4_ARATH » Wall-associated receptor kinase 4

WAK4_ARATH » Wall-associated receptor kinase 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
WAK4_ARATH » Wall-associated receptor kinase 4 »
Hydrophobic Thickness 32.4 ± 2.6 Å
Tilt Angle 3 ± 2°
ΔGtransfer -43.0 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 332-357 (330-361)
Pathways none
PDB none
OPM none
Complexes none
Interactions

UBC34, Complex: WAK4:UBC34

WAK3, Complex: WAK4:WAK3

Domains

AA: 25-125, Wall-associated receptor kinase galacturonan-binding

AA: 279-324, PDBID: 1NT0, Subunit A, Seq Identity:36%, Calcium-binding EGF domain

AA: 411-680, PDBID: 1FMK, Subunit A, Seq Identity:42%, Protein tyrosine kinase

UniProt annotation for WAK4_ARATH » Wall-associated receptor kinase 4
FUNCTION: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

TISSUE SPECIFICITY: Strictly expressed in siliques.

UniProt features for WAK4_ARATH » Wall-associated receptor kinase 4
SIGNAL 1 22 Potential.
CHAIN 23 738 Wall-associated receptor kinase 4.
DOMAIN 232 278 EGF-like 1.
DOMAIN 279 325 EGF-like 2; calcium-binding (Potential).
DOMAIN 410 693 Protein kinase.
ACT_SITE 535 535 Proton acceptor (By similarity).
DISULFID 236 250 By similarity.
DISULFID 244 261 By similarity.
DISULFID 263 277 By similarity.
DISULFID 283 300 By similarity.
DISULFID 294 309 By similarity.
DISULFID 311 324 By similarity.
Amino Acid Sequence for WAK4_ARATH » Wall-associated receptor kinase 4
MKVQRLFLVA IFCLSYMQLV KGQTLPRCPE KCGNVTLEYP FGFSPGCWRA EDPSFNLSCV NENLFYKGLE VVEISHSSQL RVLYPASYIC YNSKGKFAKG TYYWSNLGNL TLSGNNTITA LGCNSYAFVS SNGTRRNSVG CISACDALSH EANGECNGEG CCQNPVPAGN NWLIVRSYRF DNDTSVQPIS EGQCIYAFLV ENGKFKYNAS DKYSYLQNRN VGFPVVLDWS IRGETCGQVG EKKCGVNGIC SNSASGIGYT CKCKGGFQGN PYLQNGCQDI NECTTANPIH KHNCSGDSTC ENKLGHFRCN CRSRYELNTT TNTCKPKGNP EYVEWTTIVL GTTIGFLVIL LAISCIEHKM KNTKDTELRQ QFFEQNGGGM LMQRLSGAGP SNVDVKIFTE EGMKEATDGY DENRILGQGG QGTVYKGILP DNSIVAIKKA RLGDNSQVEQ FINEVLVLSQ INHRNVVKLL GCCLETEVPL LVYEFISSGT LFDHLHGSMF DSSLTWEHRL RMAVEIAGTL AYLHSSASIP IIHRDIKTAN ILLDENLTAK VADFGASRLI PMDKEDLATM VQGTLGYLDP EYYNTGLLNE KSDVYSFGVV LMELLSGQKA LCFERPQTSK HIVSYFASAT KENRLHEIID GQVMNENNQR EIQKAARIAV ECTRLTGEER PGMKEVAAEL EALRVTKTKH KWSDEYPEQE DTEHLVGVQK LSAQGETSSS IGYDSIRNVA ILDIEAGR