WAK2_ARATH » Wall-associated receptor kinase 2

WAK2_ARATH » Wall-associated receptor kinase 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
WAK2_ARATH » Wall-associated receptor kinase 2 »
Hydrophobic Thickness 33.6 ± 3.6 Å
Tilt Angle 4 ± 6°
ΔGtransfer -41.4 kcal/mol
ΔGfold -13.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 329-354 (324-358)
Pathways none
PDB none
OPM none
Complexes none
Interactions

C89A2, Complex: C89A2:WAK2

Domains

AA: 26-127, Wall-associated receptor kinase galacturonan-binding

AA: 278-319, PDBID: 1EMN, Subunit A, Seq Identity:40%, Calcium-binding EGF domain

AA: 404-674, PDBID: 1FMK, Subunit A, Seq Identity:42%, Protein tyrosine kinase

UniProt annotation for WAK2_ARATH » Wall-associated receptor kinase 2
FUNCTION: Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

TISSUE SPECIFICITY: Predominantly expressed in green tissues such as stems and leaves. Detected at organ junctions.

DEVELOPMENTAL STAGE: Expressed in shoot and root apical meristems, and in expanding leaves and sepals.

INDUCTION: Induced by INA and wounding.

UniProt features for WAK2_ARATH » Wall-associated receptor kinase 2
SIGNAL 1 23 Potential.
CHAIN 24 732 Wall-associated receptor kinase 2.
DOMAIN 230 277 EGF-like 1.
DOMAIN 278 319 EGF-like 2; calcium-binding (Potential).
DOMAIN 404 677 Protein kinase.
ACT_SITE 529 529 Proton acceptor (By similarity).
DISULFID 234 249 By similarity.
DISULFID 243 260 By similarity.
DISULFID 262 276 By similarity.
DISULFID 282 295 By similarity.
DISULFID 289 304 By similarity.
DISULFID 306 318 By similarity.
Amino Acid Sequence for WAK2_ARATH » Wall-associated receptor kinase 2
MKVQEGLFVV AVFYLAYTQL VKGQPRKECQ TRCGNVAVEY PFGTSPGCYY PGDESFNLTC NEQEKLFFGN MPVINMSLSG QLRVRLVRSR VCYDSQGKQT DYIAQRTTLG NFTLSELNRF TVVGCNSYAF LRTSGVEKYS TGCISICDSA TTKNGSCSGE GCCQIPVPRG YSFVRVKPHS FHNHPTVHLF NPCTYAFLVE DGMFDFHALE DLNNLRNVTT FPVVLDWSIG DKTCKQVEYR GVCGGNSTCF DSTGGTGYNC KCLEGFEGNP YLPNGCQDIN ECISSRHNCS EHSTCENTKG SFNCNCPSGY RKDSLNSCTR KVRPEYFRWT QIFLGTTIGF SVIMLGISCL QQKIKHRKNT ELRQKFFEQN GGGMLIQRVS GAGPSNVDVK IFTEKGMKEA TNGYHESRIL GQGGQGTVYK GILPDNSIVA IKKARLGNRS QVEQFINEVL VLSQINHRNV VKVLGCCLET EVPLLVYEFI NSGTLFDHLH GSLYDSSLTW EHRLRIATEV AGSLAYLHSS ASIPIIHRDI KTANILLDKN LTAKVADFGA SRLIPMDKEQ LTTIVQGTLG YLDPEYYNTG LLNEKSDVYS FGVVLMELLS GQKALCFERP HCPKNLVSCF ASATKNNRFH EIIDGQVMNE DNQREIQEAA RIAAECTRLM GEERPRMKEV AAELEALRVK TTKYKWSDQY RETGEIEHLL GVQILSAQGE TSSSIGYDSI RNVTTLDIEA GR