VTI1_YEAST » t-SNARE VTI1

VTI1_YEAST » t-SNARE VTI1
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
VTI1_YEAST » t-SNARE VTI1 » Qb-SNARE VTI1;VPS10-interacting protein 1;Vesicle transport v-SNARE protein VTI1;
Hydrophobic Thickness 29.2 ± 4.0 Å
Tilt Angle 30 ± 0°
ΔGtransfer -26.2 kcal/mol
ΔGfold -24.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 195-216 (191-216)
Pathways

SNARE interactions in vesicular transport (KEGG)
PDB 3onj (3-99), 3onl (C=3-99)
OPM none
Complexes none
Interactions

GOSR1, Complex: GOSR1:VTI1

NYV1, Complex: VTI1:NYV1, PubMed

PEP12, Complex: VATB:HSP75:TBA1:YKT6:VTI1:PEP12, PubMed

PEP12, Complex: VTI1:PEP12, PubMed

SEC22, Complex: SEC22:VTI1

SED5, Complex: SED5:VTI1, PubMed

SFT1, Complex: SFT1:VTI1

SNC2, Complex: VTI1:SNC2, PubMed

STX8, Complex: VTI1:STX8, PubMed

TLG1, Complex: VTI1:TLG1, PubMed

TLG2, Complex: VTI1:TLG2, PubMed

VAM3, Complex: VTI1:VAM3, PubMed

VPS10, Complex: VPS10:VTI1, PubMed

YHO0, Complex: VTI1:YHO0, PubMed
Domains

AA: 12-93, PDBID: 3ONJ, Subunit A, Seq Identity:100%, Vesicle transport v-SNARE protein N-terminus

AA: 125-190, PDBID: 2NPS, Subunit C, Seq Identity:35%, Snare region anchored in the vesicle membrane C-terminus
UniProt annotation for VTI1_YEAST » t-SNARE VTI1
FUNCTION: t-SNARE found in various SNARE complexes involved in multiple transport pathways. The composition of the t-SNARE complexes is specific for a limited number of v-SNAREs and therefore allows only the vesicles carrying the matching v-SNARE to fuse.

SUBUNIT: Forms SNARE complexes with the t-SNAREs VAM3 and VAM7, and the v-SNAREs NYV1 and YKT6 on vacuolar membranes, which are involved in biosynthetic transport pathways to the vacuole and in homotypic vacuole fusion. Forms SNARE complexes with the cis-Golgi t-SNARE SED5 and the v-SNAREs SFT1 and YTK6, which are involved in retrograde traffic to the cis-Golgi compartment. Forms SNARE complexes with the t-SNAREs TLG1 and TLG2, and either the v-SNARE SNC1 or SNC2, which are involved in traffic from early endosomes to the trans-Golgi network (TGN). Forms SNARE complexes with the t-SNAREs PEP12 and either SYN8 or TLG1, and the v-SNARE SNC1, which are involved in traffic from the TGN to the prevacuolar compartment (PVC).

UniProt features for VTI1_YEAST » t-SNARE VTI1
CHAIN 2 217 t-SNARE VTI1.
DOMAIN 124 186 t-SNARE coiled-coil homology.
Amino Acid Sequence for VTI1_YEAST » t-SNARE VTI1
MSSLLISYES DFKTTLEQAK ASLAEAPSQP LSQRNTTLKH VEQQQDELFD LLDQMDVEVN NSIGDASERA TYKAKLREWK KTIQSDIKRP LQSLVDSGDR DRLFGDLNAS NIDDDQRQQL LSNHAILQKS GDRLKDASRI ANETEGIGSQ IMMDLRSQRE TLENARQTLF QADSYVDKSI KTLKTMTRRL VANKFISYAI IAVLILLILL VLFSKFK