![]() | Golgi lumenal side |
cytoplasmic side |
VTI1_YEAST » t-SNARE VTI1 » Qb-SNARE VTI1;VPS10-interacting protein 1;Vesicle transport v-SNARE protein VTI1; | |
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Hydrophobic Thickness | 29.2 ± 4.0 Å |
Tilt Angle | 30 ± 0° |
ΔGtransfer | -26.2 kcal/mol |
ΔGfold | -24.0 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING |
Topology | In |
TM Segments | 195-216 (191-216) |
Pathways | |
PDB | 3onj (3-99), 3onl (C=3-99) |
OPM | none |
Complexes | none |
Interactions | GOSR1, Complex: GOSR1:VTI1 NYV1, Complex: VTI1:NYV1, PubMed PEP12, Complex: VATB:HSP75:TBA1:YKT6:VTI1:PEP12, PubMed PEP12, Complex: VTI1:PEP12, PubMed SEC22, Complex: SEC22:VTI1 SED5, Complex: SED5:VTI1, PubMed SFT1, Complex: SFT1:VTI1 SNC2, Complex: VTI1:SNC2, PubMed STX8, Complex: VTI1:STX8, PubMed TLG1, Complex: VTI1:TLG1, PubMed TLG2, Complex: VTI1:TLG2, PubMed VAM3, Complex: VTI1:VAM3, PubMed |
Domains | AA: 12-93, PDBID: 3ONJ, Subunit A, Seq Identity:100%, Vesicle transport v-SNARE protein N-terminus AA: 125-190, PDBID: 2NPS, Subunit C, Seq Identity:35%, Snare region anchored in the vesicle membrane C-terminus |
UniProt annotation for VTI1_YEAST » t-SNARE VTI1 |
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FUNCTION: t-SNARE found in various SNARE complexes involved in multiple transport pathways. The composition of the t-SNARE complexes is specific for a limited number of v-SNAREs and therefore allows only the vesicles carrying the matching v-SNARE to fuse. SUBUNIT: Forms SNARE complexes with the t-SNAREs VAM3 and VAM7, and the v-SNAREs NYV1 and YKT6 on vacuolar membranes, which are involved in biosynthetic transport pathways to the vacuole and in homotypic vacuole fusion. Forms SNARE complexes with the cis-Golgi t-SNARE SED5 and the v-SNAREs SFT1 and YTK6, which are involved in retrograde traffic to the cis-Golgi compartment. Forms SNARE complexes with the t-SNAREs TLG1 and TLG2, and either the v-SNARE SNC1 or SNC2, which are involved in traffic from early endosomes to the trans-Golgi network (TGN). Forms SNARE complexes with the t-SNAREs PEP12 and either SYN8 or TLG1, and the v-SNARE SNC1, which are involved in traffic from the TGN to the prevacuolar compartment (PVC). |
UniProt features for VTI1_YEAST » t-SNARE VTI1 |
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CHAIN 2 217 t-SNARE VTI1. DOMAIN 124 186 t-SNARE coiled-coil homology. |
Amino Acid Sequence for VTI1_YEAST » t-SNARE VTI1 |
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MSSLLISYES DFKTTLEQAK ASLAEAPSQP LSQRNTTLKH VEQQQDELFD LLDQMDVEVN NSIGDASERA TYKAKLREWK KTIQSDIKRP LQSLVDSGDR DRLFGDLNAS NIDDDQRQQL LSNHAILQKS GDRLKDASRI ANETEGIGSQ IMMDLRSQRE TLENARQTLF QADSYVDKSI KTLKTMTRRL VANKFISYAI IAVLILLILL VLFSKFK |