VTI1B_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1B

VTI1B_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1B
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VTI1B_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1B » Vesicle transport v-SNARE protein Vti1-like 1;Vti1-rp1;
Hydrophobic Thickness 32.4 ± 2.8 Å
Tilt Angle 31 ± 0°
ΔGtransfer -22.7 kcal/mol
ΔGfold -14.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 203-228 (200-229)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB 2v8s (V=1-96)
OPM none
Complexes

STX7:VTI1B:VAMP8:STX8_MOUSE

Interactions

GOGB1, Complex: GOGB1:VTI1B, PubMed

LRAD1, Complex: VTI1B:LRAD1

STX17, Complex: STX17:VTI1B

STX4, Complex: STX4:VTI1B

STX5, Complex: VTI1B:STX5, PubMed

STX7, Complex: STX7:STX8:VAMP8:VTI1B, PDBID: 1gl2

STX8, Complex: STX7:STX8:VAMP8:VTI1B, PDBID: 1gl2

SYNE4, Complex: SYNE4:VTI1B

TRI59, Complex: VTI1B:TRI59

VAMP4, Complex: VTI1B:VAMP4, PubMed

VAMP8, Complex: STX7:STX8:VAMP8:VTI1B, PDBID: 1gl2

Domains

AA: 18-97, PDBID: 2V8S, Subunit V, Seq Identity:100%, Vesicle transport v-SNARE protein N-terminus

AA: 137-202, PDBID: 1GL2, Subunit C, Seq Identity:97%, Snare region anchored in the vesicle membrane C-terminus

UniProt annotation for VTI1B_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1B
FUNCTION: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

SUBUNIT: Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VIT1B that is required for heterotypic fusion of late endosomes with lysosomes (By similarity). May interact with STX17.

TISSUE SPECIFICITY: Expressed in all tissues examined.

UniProt features for VTI1B_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1B
CHAIN 1 232 Vesicle transport through interaction with t-SNAREs homolog 1B.
COILED 35 98 Potential.
COILED 161 198 Potential.
Amino Acid Sequence for VTI1B_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1B
MASSAASSEH FEKLHEIFRG LHEDLQGVPE RLLGTAGTEE KKKLIRDFDE KQQEANETLA EMEEELRYAP LSFRNPMMSK LRNYRKDLAK LHREVRSTPL TATPGGRGDM KYGIYAVENE HMNRLQSQRA MLLQGTESLN RATQSIERSH RIATETDQIG SEIIEELGEQ RDQLERTKSR LVNTSENLSK SRKILRSMSR KVTTNKLLLS IIILLELAIL GGLVYYKFFR SH