VTI1A_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1A

VTI1A_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1A
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VTI1A_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1A » Vesicle transport v-SNARE protein Vti1-like 2;Vti1-rp2;
Hydrophobic Thickness 34.0 ± 2.2 Å
Tilt Angle 9 ± 0°
ΔGtransfer -26.9 kcal/mol
ΔGfold -22.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 192-214 (192-216)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM 2nps (RAT)
Complexes

STX12:VAMP4:VTI1A:STX6_RAT

Interactions

STX12, Complex: STX12:VTI1A, PubMed

STX16, Complex: STX16:VTI1A, PubMed

STX6, Complex: STX6:VAMP4:VTI1A, PDBID: 2nps

STX7, Complex: STX7:VTI1A, PubMed

STX8, Complex: VTI1A:STX8, PubMed

VAMP3, Complex: VTI1A:VAMP3, PubMed

VAMP4, Complex: STX6:VAMP4:VTI1A, PDBID: 2nps

VAMP8, Complex: VTI1A:VAMP8, PubMed

Domains

AA: 12-90, PDBID: 1VCS, Subunit A, Seq Identity:98%, Vesicle transport v-SNARE protein N-terminus

AA: 123-188, PDBID: 2NPS, Subunit C, Seq Identity:98%, Snare region anchored in the vesicle membrane C-terminus

UniProt annotation for VTI1A_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1A
FUNCTION: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

SUBUNIT: Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

UniProt features for VTI1A_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1A
CHAIN 1 217 Vesicle transport through interaction with t-SNAREs homolog 1A.
COILED 31 92 Potential.
COILED 112 178 Potential.
Amino Acid Sequence for VTI1A_HUMAN » Vesicle transport through interaction with t-SNAREs homolog 1A
MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEAKE LLEQMDLEVR EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR NELLGDDGNS SENQRAHLLD NTERLERSSR RLEAGYQIAV ETEQIGQEML ENLSHDREKI QRARERLRET DANLGKSSRI LTGMLRRIIQ NRILLVILGI IVVITILMAI TFSVRRH