VTI1A_DICDI » Vesicle transport through interaction with t-SNAREs homolog 1A

VTI1A_DICDI » Vesicle transport through interaction with t-SNAREs homolog 1A
Magnify VTI1A_DICDI » Vesicle transport through interaction with t-SNAREs homolog 1AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VTI1A_DICDI » Vesicle transport through interaction with t-SNAREs homolog 1A »
Hydrophobic Thickness 30.8 ± 3.8 Å
Tilt Angle 29 ± 23°
ΔGtransfer -26.3 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 193-216 (193-216)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM 2nps (RAT)
Complexes

STX12:VAMP4:VTI1A:STX6_RAT

Interactions

STX7A, Complex: STX7A:VTI1A, PubMed

Domains

AA: 11-87, PDBID: 2QYW, Subunit A, Seq Identity:29%, Vesicle transport v-SNARE protein N-terminus

AA: 124-189, PDBID: 2NPS, Subunit C, Seq Identity:37%, Snare region anchored in the vesicle membrane C-terminus

UniProt annotation for VTI1A_DICDI » Vesicle transport through interaction with t-SNAREs homolog 1A
FUNCTION: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.

SUBUNIT: Component of the SNARE complex composed of syn7A, syn8A, vamp7A and vti1A.

DEVELOPMENTAL STAGE: Expressed during development. Expression levels peak at 2 hours, after which they decrease steadily until culmination. Levels increase after 18 hours of development.

UniProt features for VTI1A_DICDI » Vesicle transport through interaction with t-SNAREs homolog 1A
CHAIN 1 217 Vesicle transport through interaction with t-SNAREs homolog 1A.
DOMAIN 123 185 t-SNARE coiled-coil homology.
COILED 36 97 Potential.
Amino Acid Sequence for VTI1A_DICDI » Vesicle transport through interaction with t-SNAREs homolog 1A
MDVFERTEQN FQHVCNSITR RIKQLPNYGG EKKKIAVREV ENDIDEALKF ISEMEKLAQN HPQRIKLQTK TKQYHSDIQK YKREVQLAQL QSSNQTNSNP WSNAPDDYQS QYDNQRQHLL QGSNMLDSTS DRLLRTHQIS AQSEQIGQNI LMDLGKQGEQ IRGMRDKLHE TDDQIKSARK IMTGIARRLA TNKVILSIII LLLMGIIALI ICLKWLR