VTI12_ARATH » Vesicle transport v-SNARE 12

VTI12_ARATH » Vesicle transport v-SNARE 12
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VTI12_ARATH » Vesicle transport v-SNARE 12 » AtVTI12; Vesicle soluble NSF attachment protein receptor VTI1b;AtVTI1b; Vesicle transport v-SNARE protein VTI1b;
Hydrophobic Thickness 31.8 ± 2.3 Å
Tilt Angle 4 ± 2°
ΔGtransfer -25.7 kcal/mol
ΔGfold -22.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 199-220 (198-221)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BETL2, Complex: VTI12:BETL2

ERL1, Complex: VTI12:ERL1

NPS11, Complex: VTI12:NPS11, PubMed

PAM74, Complex: VTI12:PAM74

SYP22, Complex: SYP22:VTI12

SYP41, Complex: SYP41:VTI12

SYP42, Complex: VTI12:SYP42, PubMed

SYP43, Complex: SYP43:VTI12, PubMed

SYP51, Complex: SYP51:VTI12

SYP61, Complex: SYP61:VTI12

Domains

AA: 12-91, PDBID: 1VCS, Subunit A, Seq Identity:29%, Vesicle transport v-SNARE protein N-terminus

AA: 129-194, PDBID: 2NPS, Subunit C, Seq Identity:35%, Snare region anchored in the vesicle membrane C-terminus

UniProt annotation for VTI12_ARATH » Vesicle transport v-SNARE 12
FUNCTION: May function as a v-SNARE responsible for the docking or fusion of transport vesicles within the trans-Golgi network (TGN). May be also involved in retrograde traffic to the cis-Golgi (By similarity).

SUBUNIT: Forms SNARE complexes with the t-SNAREs SYP61 and either SYP41 or SYP42, and with a much lower affinity with SYP51 in the TGN. Interacts also with VPS45, a Sec1 protein, but not with SYP21 or SYP22. Binds to EPSIN2.

TISSUE SPECIFICITY: Expressed in roots, stems, flowers and leaves.

UniProt features for VTI12_ARATH » Vesicle transport v-SNARE 12
CHAIN 1 222 Vesicle transport v-SNARE 12.
COILED 68 95 Potential.
Amino Acid Sequence for VTI12_ARATH » Vesicle transport v-SNARE 12
MSDVFEGYER QYCELSTNLS RKCHSASVLS NGEEKKGKIA EIKSGIDEAD VLIRKMDLEA RSLQPSAKAV CLSKLREYKS DLNQLKKEFK RVSSADAKPS SREELMESGM ADLHAVSADQ RGRLAMSVER LDQSSDRIRE SRRLMLETEE VGISIVQDLS QQRQTLLHAH NKLHGVDDAI DKSKKVLTAM SRRMTRNKWI ITSVIVALVL AIILIISYKL SH