VTH1_YEAST » VPS10 homolog 1

VTH1_YEAST » VPS10 homolog 1
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
VTH1_YEAST » VPS10 homolog 1 » Sortilin VTH1;
Hydrophobic Thickness 33.6 ± 2.4 Å
Tilt Angle 3 ± 3°
ΔGtransfer -29.4 kcal/mol
ΔGfold -26.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 1370-1392 (1369-1396)
Pathways none
PDB none
OPM none
Complexes none
Interactions

VPS10, Complex: VPS10:VTH1

Domains

AA: 537-692, PDBID: 3WSX, Subunit A, Seq Identity:23%, Sortilin, neurotensin receptor 3, C-terminal

AA: 737-1184, PDBID: 3WSX, Subunit A, Seq Identity:16%, Sortilin, neurotensin receptor 3,

AA: 1186-1354, PDBID: 3WSX, Subunit A, Seq Identity:29%, Sortilin, neurotensin receptor 3, C-terminal

UniProt annotation for VTH1_YEAST » VPS10 homolog 1
FUNCTION: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.

MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.

UniProt features for VTH1_YEAST » VPS10 homolog 1
SIGNAL 1 21 Potential.
CHAIN 22 1549 VPS10 homolog 1.
REPEAT 57 68 BNR 1.
REPEAT 101 112 BNR 2.
REPEAT 159 170 BNR 3.
REPEAT 228 239 BNR 4.
REPEAT 393 404 BNR 5.
REPEAT 465 476 BNR 6.
REPEAT 511 522 BNR 7.
REPEAT 740 751 BNR 8.
REPEAT 837 848 BNR 9.
REPEAT 1040 1051 BNR 10.
REPEAT 1119 1130 BNR 11.
REPEAT 1160 1171 BNR 12.
Amino Acid Sequence for VTH1_YEAST » VPS10 homolog 1
MALFRALYII WVFLLIPLSN AEEFTPKVTR TLSRYVFDIV NFDDSNTLIR AEEDSVEISF DAGENWKTID EIEEPIESFV VDPFRGHDRA FAFVKTAPKF YVTDDQGKSW RPLTIPISEK ASNYFCDVTT HPIKKKHLII RCDLLTIKNS GLMYVGREIY TTNDGVSFSQ VKPSFGKIDG HISTARCDFI KSSEDSDLGG NDASILCLFR NTEYIESTGS TIDKSELILS ADGGETFKEL VQFKDKVVSR YEILKHHVIV LTQDDMYNEM SSTNIWISND VSTFQVARTP TKIRHVNMGQ IHEDSIGRIV LPVSRERDDE DSNQPGAAEV LISDSEGLKF LPINWIPNNQ FGYINVAYPG FLKGTFFGSF HPFIEYSDRK RKYSRQKVRE ETKVSVDNGL TWTNLKVVDR ENVDLFGCDV TKPERCSLQT HFYDLRNLNP SAGIMMISGI VGDGSAYNWK EEKTFISRDS GLTWRLVHNS TGLYTTGDLG NIIMYIPYRS NENGDVPSKF YYSLDQGKTW GEYDLIMPIY PYRLVSTISD GSGSKFILTG TSITEDPIFI TYSIDFSAVF DYKSCEEGDF EDWNLADGKC VNGAKYKYRR RKQDAQCLVK KAFKDLSLDE TPCNSCTGSD YECSFEFVRD AKGDCIPDYN LIALSDICDK SKGKSVLVKP LQLIKGDKCK TPMKIESVDI PCDEIPKEGS SDKEIVTTEN KFDFEIKFYQ YFDTVADESL VMLNSIGDAY ISHDGGQTIK RFDTDGEKIV EIVFNPYFNS SAYLFGSKGN IFLTHDRGYS FMIAKLPEAR QLGMPLDFSA KAQDTFIYYG GKNCESILSP ECHAVAYLTK DGGETFTEML DNAIHCEFAG TLFKYPSNDD MVMCQVKEKF SQTRSLVSST DFFQDDRKTV FENIIGYLST GGYIIVAVPH EDNELRAYVT NDGAEFTEAK FPYDEDIGKQ DAFTILGSEE GSIFLHLATN LESGHDFGNL LKSNSNGTSF VTLEHAVNRN TFGYVDFEKV QGLEGIIITN IVSNSEKVGE NKEDEQLKTK ITFNDGSDWN FLKPPKKDSE GKKFPCDSVS LDKCSLHLHG YTERKDIRDT YSSGSALGMM FGVGNVGDRL LPYEECSTFL TTDGGETWTE VKKGPHQWEY GDHGGVLVLV PENAETDSIS YSTDFGKTWK DYKFCGDKVL VKDIITVPRD SALRFLLFGE AKNMGSGSFR TYTIDFRNIF ERQCEFDITG RKRADFKYSP LGSRTGCLFG HKTEFLRKTD EKCFIGNIPL SEFSRNVKNC PCTRQDFECD YNFYKASDGT CKLVKGLSSA NGADICKKEP DLIEYYDSSG YRKIPLSTCK GGLKLDAHLA PHPCPGKEKA FREKYSINTG AYALVFVTIL LVIFFVAWFV YDRGIRRNGG FSRFEEIRLG DDGLIENNRT DRVVNIIVRL GLCISLITKS AFQRAKAGTA QLSSKFRARF GNKKGATYSS LLHDQLSDEP DGFHEDSNDL SSFRGQGSNS EIEQEDVDTS QQEHTLRTDL LGASNIPDAL PARSASHESD LAAARSEDK