VTCN1_HUMAN » V-set domain-containing T-cell activation inhibitor 1

VTCN1_HUMAN » V-set domain-containing T-cell activation inhibitor 1
Magnify VTCN1_HUMAN » V-set domain-containing T-cell activation inhibitor 1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
VTCN1_HUMAN » V-set domain-containing T-cell activation inhibitor 1 » B7h.5;Immune costimulatory protein B7-H4;Protein B7S1;T-cell costimulatory molecule B7x;
Hydrophobic Thickness 30.6 ± 3.2 Å
Tilt Angle 8 ± 0°
ΔGtransfer -20.6 kcal/mol
ΔGfold -5.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 260-281 (256-281)
Pathways

Cell adhesion molecules (KEGG)

PDB 4gos (30-148)
OPM none
Complexes none
Interactions

BTLA, Complex: BTLA:VTCN1, PubMed

Domains

AA: 40-147, PDBID: 4GOS, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for VTCN1_HUMAN » V-set domain-containing T-cell activation inhibitor 1
FUNCTION: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

TISSUE SPECIFICITY: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

INDUCTION: Up-regulated by IL6/interleukin-6 and IL10/interleukin- 10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen- presenting cells (APCs).

MISCELLANEOUS: May serve as a predictive marker for renal cell carcinoma.

UniProt features for VTCN1_HUMAN » V-set domain-containing T-cell activation inhibitor 1
SIGNAL 1 24 Potential.
CHAIN 25 282 V-set domain-containing T-cell activation inhibitor 1.
DOMAIN 35 146 Ig-like V-type 1.
DOMAIN 153 241 Ig-like V-type 2.
DISULFID 56 130 By similarity.
DISULFID 168 225 By similarity.
Amino Acid Sequence for VTCN1_HUMAN » V-set domain-containing T-cell activation inhibitor 1
MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE DGILSCTFEP DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR TAVFADQVIV GNASLRLKNV QLTDAGTYKC YIITSKGKGN ANLEYKTGAF SMPEVNVDYN ASSETLRCEA PRWFPQPTVV WASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TESEIKRRSH LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK