VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1

VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1 »
Hydrophobic Thickness 34.8 ± 1.3 Å
Tilt Angle 24 ± 12°
ΔGtransfer -29.7 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 135-157 (131-161)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-117, PDBID: 2OTP, Subunit B, Seq Identity:35%, Immunoglobulin domain

UniProt annotation for VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1
FUNCTION: Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).

FUNCTION: Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.

TISSUE SPECIFICITY: Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.

DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. Both motives are required for full inhibition of FCER1A-mediated degranulation.

UniProt features for VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1
SIGNAL 1 16
CHAIN 17 236 V-set and transmembrane domain-containing protein 1.
DOMAIN 27 114 Ig-like V-type.
DISULFID 49 96 By similarity.
Amino Acid Sequence for VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1
MTAEFLSLLC LGLCLGYEDE KKNEKPPKPS LHAWPSSVVE AESNVTLKCQ AHSQNVTFVL RKVNDSGYKQ EQSSAENEAE FPFTDLKPKD AGRYFCAYKT TASHEWSESS EHLQLVVTDK HDELEAPSMK TDTRTIFVAI FSCISILLLF LSVFIIYRCS QHGSSSEEST KRTSHSKLPE QEAAEADLSN MERVSLSTAD PQGVTYAELS TSALSEAASD TTQEPPGSHE YAALKV