|VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1 »|
|Hydrophobic Thickness||34.8 ± 1.3 Å|
|Tilt Angle||24 ± 12°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||135-157 (131-161)|
|UniProt annotation for VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1|
|FUNCTION: Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17). FUNCTION: Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes. TISSUE SPECIFICITY: Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells. DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. Both motives are required for full inhibition of FCER1A-mediated degranulation.|
|UniProt features for VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1|
SIGNAL 1 16 |
CHAIN 17 236 V-set and transmembrane domain-containing protein 1.
DOMAIN 27 114 Ig-like V-type.
DISULFID 49 96 By similarity.
|Amino Acid Sequence for VSTM1_HUMAN » V-set and transmembrane domain-containing protein 1|
|MTAEFLSLLC LGLCLGYEDE KKNEKPPKPS LHAWPSSVVE AESNVTLKCQ AHSQNVTFVL RKVNDSGYKQ EQSSAENEAE FPFTDLKPKD AGRYFCAYKT TASHEWSESS EHLQLVVTDK HDELEAPSMK TDTRTIFVAI FSCISILLLF LSVFIIYRCS QHGSSSEEST KRTSHSKLPE QEAAEADLSN MERVSLSTAD PQGVTYAELS TSALSEAASD TTQEPPGSHE YAALKV|