VSIG4_HUMAN » V-set and immunoglobulin domain-containing protein 4

VSIG4_HUMAN » V-set and immunoglobulin domain-containing protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
VSIG4_HUMAN » V-set and immunoglobulin domain-containing protein 4 » Protein Z39Ig;
Hydrophobic Thickness 38.8 ± 3.0 Å
Tilt Angle 1 ± 1°
ΔGtransfer -43.0 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 281-306 (281-312)
Pathways none
PDB 2icc (19-137), 2ice (S/T=19-137), 2icf (S=19-137)
OPM none
Complexes none
Interactions

A4, Complex: VSIG4:A4, PubMed

Domains

AA: 24-136, PDBID: 2ICC, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 142-214, PDBID: 1NBQ, Subunit B, Seq Identity:31%, Immunoglobulin domain

UniProt annotation for VSIG4_HUMAN » V-set and immunoglobulin domain-containing protein 4
FUNCTION: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

TISSUE SPECIFICITY: Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.

UniProt features for VSIG4_HUMAN » V-set and immunoglobulin domain-containing protein 4
SIGNAL 1 19
CHAIN 20 399 V-set and immunoglobulin domain- containing protein 4.
DOMAIN 21 131 Ig-like 1.
DOMAIN 143 226 Ig-like 2.
DISULFID 41 113
DISULFID 165 211 By similarity.
Amino Acid Sequence for VSIG4_HUMAN » V-set and immunoglobulin domain-containing protein 4
MGILLGLLLL GHLTVDTYGR PILEVPESVT GPWKGDVNLP CTYDPLQGYT QVLVKWLVQR GSDPVTIFLR DSSGDHIQQA KYQGRLHVSH KVPGDVSLQL STLEMDDRSH YTCEVTWQTP DGNQVVRDKI TELRVQKLSV SKPTVTTGSG YGFTVPQGMR ISLQCQARGS PPISYIWYKQ QTNNQEPIKV ATLSTLLFKP AVIADSGSYF CTAKGQVGSE QHSDIVKFVV KDSSKLLKTK TEAPTTMTYP LKATSTVKQS WDWTTDMDGY LGETSAGPGK SLPVFAIILI ISLCCMVVFT MAYIMLCRKT SQQEHVYEAA RAHAREANDS GETMRVAIFA SGCSSDEPTS QNLGNNYSDE PCIGQEYQII AQINGNYARL LDTVPLDYEF LATEGKSVC