VSIG1_HUMAN » V-set and immunoglobulin domain-containing protein 1

VSIG1_HUMAN » V-set and immunoglobulin domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
VSIG1_HUMAN » V-set and immunoglobulin domain-containing protein 1 » Cell surface A33 antigen;Glycoprotein A34;
Hydrophobic Thickness 34.4 ± 1.2 Å
Tilt Angle 0 ± 3°
ΔGtransfer -45.8 kcal/mol
ΔGfold -15.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 232-257 (231-263)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 27-137, PDBID: 1DR9, Subunit A, Seq Identity:27%, Immunoglobulin V-set domain

AA: 142-215, PDBID: 1F97, Subunit A, Seq Identity:29%, Immunoglobulin domain

UniProt annotation for VSIG1_HUMAN » V-set and immunoglobulin domain-containing protein 1
TISSUE SPECIFICITY: Detected only in stomach mucosa and testis, and to a much lesser level in pancreas (at protein level). Detected in gastric cancers (31%), esophageal carcinomas (50%) and ovarian cancers (23%).
UniProt features for VSIG1_HUMAN » V-set and immunoglobulin domain-containing protein 1
SIGNAL 1 21 Potential.
CHAIN 22 387 V-set and immunoglobulin domain- containing protein 1.
DOMAIN 22 132 Ig-like V-type 1.
DOMAIN 140 227 Ig-like C2-type 2.
DISULFID 43 116 By similarity.
DISULFID 161 211 By similarity.
Amino Acid Sequence for VSIG1_HUMAN » V-set and immunoglobulin domain-containing protein 1
MVFAFWKVFL ILSCLAGQVS VVQVTIPDGF VNVTVGSNVT LICIYTTTVA SREQLSIQWS FFHKKEMEPI SIYFSQGGQA VAIGQFKDRI TGSNDPGNAS ITISHMQPAD SGIYICDVNN PPDFLGQNQG ILNVSVLVKP SKPLCSVQGR PETGHTISLS CLSALGTPSP VYYWHKLEGR DIVPVKENFN PTTGILVIGN LTNFEQGYYQ CTAINRLGNS SCEIDLTSSH PEVGIIVGAL IGSLVGAAII ISVVCFARNK AKAKAKERNS KTIAELEPMT KINPRGESEA MPREDATQLE VTLPSSIHET GPDTIQEPDY EPKPTQEPAP EPAPGSEPMA VPDLDIELEL EPETQSELEP EPEPEPESEP GVVVEPLSED EKGVVKA