VOPP1_HUMAN » Vesicular, overexpressed in cancer, prosurvival protein 1

VOPP1_HUMAN » Vesicular, overexpressed in cancer, prosurvival protein 1
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VOPP1_HUMAN » Vesicular, overexpressed in cancer, prosurvival protein 1 » EGFR-coamplified and overexpressed protein;ECop; Glioblastoma-amplified secreted protein;Putative NF-kappa-B-activating protein 055N;
Hydrophobic Thickness 34.8 ± 2.9 Å
Tilt Angle 1 ± 2°
ΔGtransfer -21.9 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 60-82 (56-86)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for VOPP1_HUMAN » Vesicular, overexpressed in cancer, prosurvival protein 1
FUNCTION: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.

TISSUE SPECIFICITY: Widely expressed with highest levels in thymus and ovary.

UniProt features for VOPP1_HUMAN » Vesicular, overexpressed in cancer, prosurvival protein 1
SIGNAL 1 22 Potential.
CHAIN 23 172 Vesicular, overexpressed in cancer, prosurvival protein 1.
Amino Acid Sequence for VOPP1_HUMAN » Vesicular, overexpressed in cancer, prosurvival protein 1
MRRQPAKVAA LLLGLLLECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC CVRALSIQRL WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK