VLDLR_HUMAN » Very low-density lipoprotein receptor

VLDLR_HUMAN » Very low-density lipoprotein receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
VLDLR_HUMAN » Very low-density lipoprotein receptor » VLDL receptor; VLDL-R;
Hydrophobic Thickness 29.2 ± 3.7 Å
Tilt Angle 1 ± 0°
ΔGtransfer -24.6 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 798-818 (796-827)
Pathways none
PDB 1v9u (111-151), 3dpr (113-151)
OPM none
Complexes none
Interactions none
Domains

AA: 31-67, PDBID: 2M0P, Subunit A, Seq Identity:58%, Low-density lipoprotein receptor domain class A

AA: 70-108, PDBID: 2KNX, Subunit A, Seq Identity:57%, Low-density lipoprotein receptor domain class A

AA: 111-149, PDBID: 1V9U, Subunit 5, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 152-188, PDBID: 1N7D, Subunit A, Seq Identity:61%, Low-density lipoprotein receptor domain class A

AA: 191-229, PDBID: 1N7D, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

AA: 237-273, PDBID: 1AJJ, Subunit A, Seq Identity:66%, Low-density lipoprotein receptor domain class A

AA: 276-312, PDBID: 1D2J, Subunit A, Seq Identity:66%, Low-density lipoprotein receptor domain class A

AA: 316-355, PDBID: 1N7D, Subunit A, Seq Identity:69%, Low-density lipoprotein receptor domain class A

AA: 360-394, PDBID: 3S94, Subunit A, Seq Identity:54%, Coagulation Factor Xa inhibitory site

AA: 396-434, PDBID: 1EMN, Subunit A, Seq Identity:46%, Calcium-binding EGF domain

AA: 481-522, PDBID: 3S94, Subunit B, Seq Identity:34%, Low-density lipoprotein receptor repeat class B

AA: 525-565, PDBID: 1IJQ, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor repeat class B

AA: 568-609, PDBID: 1IJQ, Subunit A, Seq Identity:72%, Low-density lipoprotein receptor repeat class B

AA: 612-654, PDBID: 1IJQ, Subunit A, Seq Identity:55%, Low-density lipoprotein receptor repeat class B

AA: 655-695, PDBID: 1IJQ, Subunit A, Seq Identity:44%, Low-density lipoprotein receptor repeat class B

UniProt annotation for VLDLR_HUMAN » Very low-density lipoprotein receptor
FUNCTION: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).

SUBUNIT: Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Interacts with PCSK9.

TISSUE SPECIFICITY: Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

DISEASE: Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1) OMIM: A congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation, cerebellar hypoplasia and mild cerebral gyral simplification. Additional features include short stature, strabismus, pes planus and, rarely, seizures. mutations affecting the gene represented in this entry.

UniProt features for VLDLR_HUMAN » Very low-density lipoprotein receptor
SIGNAL 1 27 Potential.
CHAIN 28 873 Very low-density lipoprotein receptor.
DOMAIN 31 69 LDL-receptor class A 1.
DOMAIN 70 110 LDL-receptor class A 2.
DOMAIN 111 151 LDL-receptor class A 3.
DOMAIN 152 190 LDL-receptor class A 4.
DOMAIN 191 231 LDL-receptor class A 5.
DOMAIN 237 275 LDL-receptor class A 6.
DOMAIN 276 314 LDL-receptor class A 7.
DOMAIN 316 355 LDL-receptor class A 8.
DOMAIN 356 395 EGF-like 1.
DOMAIN 396 435 EGF-like 2; calcium-binding (Potential).
REPEAT 439 480 LDL-receptor class B 1.
REPEAT 481 524 LDL-receptor class B 2.
REPEAT 525 567 LDL-receptor class B 3.
REPEAT 568 611 LDL-receptor class B 4.
REPEAT 612 654 LDL-receptor class B 5.
REPEAT 655 697 LDL-receptor class B 6.
DOMAIN 702 750 EGF-like 3.
REGION 751 790 Clustered O-linked oligosaccharides.
MOTIF 832 837 Endocytosis signal (Potential).
DISULFID 33 45 By similarity.
DISULFID 40 58 By similarity.
DISULFID 52 67 By similarity.
DISULFID 72 84 By similarity.
DISULFID 79 97 By similarity.
DISULFID 91 108 By similarity.
DISULFID 113 127
DISULFID 120 140
DISULFID 134 149
DISULFID 154 166 By similarity.
DISULFID 161 179 By similarity.
DISULFID 173 188 By similarity.
DISULFID 193 205 By similarity.
DISULFID 200 218 By similarity.
DISULFID 212 229 By similarity.
DISULFID 239 251 By similarity.
DISULFID 246 264 By similarity.
DISULFID 258 273 By similarity.
DISULFID 278 290 By similarity.
DISULFID 285 303 By similarity.
DISULFID 297 312 By similarity.
DISULFID 318 331 By similarity.
DISULFID 326 344 By similarity.
DISULFID 338 355 By similarity.
DISULFID 360 371 By similarity.
DISULFID 367 380 By similarity.
DISULFID 382 394 By similarity.
DISULFID 400 410 By similarity.
DISULFID 406 419 By similarity.
DISULFID 421 434 By similarity.
DISULFID 706 719 By similarity.
DISULFID 715 734 By similarity.
DISULFID 736 749 By similarity.
CROSSLNK 839 839 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
Amino Acid Sequence for VLDLR_HUMAN » Very low-density lipoprotein receptor
MGTSALWALW LLLALCWAPR ESGATGTGRK AKCEPSQFQC TNGRCITLLW KCDGDEDCVD GSDEKNCVKK TCAESDFVCN NGQCVPSRWK CDGDPDCEDG SDESPEQCHM RTCRIHEISC GAHSTQCIPV SWRCDGENDC DSGEDEENCG NITCSPDEFT CSSGRCISRN FVCNGQDDCS DGSDELDCAP PTCGAHEFQC STSSCIPISW VCDDDADCSD QSDESLEQCG RQPVIHTKCP ASEIQCGSGE CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDISKVCNQ EQDCRDWSDE PLKECHINEC LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC QNPGICSQIC INLKGGYKCE CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD IRKIGLERKE YIQLVEQLRN TVALDADIAA QKLFWADLSQ KAIFSASIDD KVGRHVKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA TLDGTKRKFL FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTADIQ WPNGITLDLI KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL TIFEDRVYWI DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP SGKNWCEEDM ENGGCEYLCL PAPQINDHSP KYTCSCPSGY NVEENGRDCQ STATTVTYSE TKDTNTTEIS ATSGLVPGGI NVTTAVSEVS VPPKGTSAAW AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT TEEDLSIDIG RHSASVGHTY PAISVVSTDD DLA