VASN_HUMAN » Vasorin

VASN_HUMAN » Vasorin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
VASN_HUMAN » Vasorin » Protein slit-like 2;
Hydrophobic Thickness 34.8 ± 0.9 Å
Tilt Angle 5 ± 13°
ΔGtransfer -24.6 kcal/mol
ΔGfold -20.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 574-596 (574-608)
Pathways none
PDB none
OPM none
Complexes none
Interactions

NICA, Complex: NICA:VASN:PSN1, PubMed

NICA, Complex: NICA:VASN, PubMed

Domains

AA: 56-112, PDBID: 3J0A, Subunit A, Seq Identity:47%, Leucine rich repeat

AA: 100-160, PDBID: 3ZYN, Subunit A, Seq Identity:46%, Leucine rich repeat

AA: 192-250, PDBID: 2Z7X, Subunit A, Seq Identity:40%, Leucine rich repeat

AA: 409-440, PDBID: 4XBM, Subunit B, Seq Identity:48%, EGF-like domain

UniProt annotation for VASN_HUMAN » Vasorin
FUNCTION: May act as an inhibitor of TGF-beta signaling.

SUBUNIT: Interacts with TGFB1, TGFB2 and TGFB3.

TISSUE SPECIFICITY: Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.

UniProt features for VASN_HUMAN » Vasorin
SIGNAL 1 23 Potential.
CHAIN 24 673 Vasorin.
DOMAIN 24 51 LRRNT.
REPEAT 52 74 LRR 1.
REPEAT 77 98 LRR 2.
REPEAT 101 122 LRR 3.
REPEAT 125 146 LRR 4.
REPEAT 149 170 LRR 5.
REPEAT 171 191 LRR 6.
REPEAT 193 214 LRR 7.
REPEAT 217 238 LRR 8.
REPEAT 240 262 LRR 9.
REPEAT 265 287 LRR 10.
DOMAIN 298 351 LRRCT.
DOMAIN 405 442 EGF-like.
DOMAIN 458 555 Fibronectin type-III.
DISULFID 409 420 By similarity.
DISULFID 414 430 By similarity.
DISULFID 432 441 By similarity.
Amino Acid Sequence for VASN_HUMAN » Vasorin
MCSRVPLLLP LLLLLALGPG VQGCPSGCQC SQPQTVFCTA RQGTTVPRDV PPDTVGLYVF ENGITMLDAG SFAGLPGLQL LDLSQNQIAS LPSGVFQPLA NLSNLDLTAN RLHEITNETF RGLRRLERLY LGKNRIRHIQ PGAFDTLDRL LELKLQDNEL RALPPLRLPR LLLLDLSHNS LLALEPGILD TANVEALRLA GLGLQQLDEG LFSRLRNLHD LDVSDNQLER VPPVIRGLRG LTRLRLAGNT RIAQLRPEDL AGLAALQELD VSNLSLQALP GDLSGLFPRL RLLAAARNPF NCVCPLSWFG PWVRESHVTL ASPEETRCHF PPKNAGRLLL ELDYADFGCP ATTTTATVPT TRPVVREPTA LSSSLAPTWL SPTEPATEAP SPPSTAPPTV GPVPQPQDCP PSTCLNGGTC HLGTRHHLAC LCPEGFTGLY CESQMGQGTR PSPTPVTPRP PRSLTLGIEP VSPTSLRVGL QRYLQGSSVQ LRSLRLTYRN LSGPDKRLVT LRLPASLAEY TVTQLRPNAT YSVCVMPLGP GRVPEGEEAC GEAHTPPAVH SNHAPVTQAR EGNLPLLIAP ALAAVLLAAL AAVGAAYCVR RGRAMAAAAQ DKGQVGPGAG PLELEGVKVP LEPGPKATEG GGEALPSGSE CEVPLMGFPG PGLQSPLHAK PYI