|VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A » VAMP-A; VAMP-associated protein A; VAP-A; 33 kDa VAMP-associated protein;VAP-33;|
|Hydrophobic Thickness||30.4 ± 1.4 Å|
|Tilt Angle||2 ± 1°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome|
|TM Segments||227-247 (227-247)|
Tight junction (KEGG)
|UniProt annotation for VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A|
|FUNCTION: May play a role in vesicle trafficking. SUBUNIT: Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN. Interacts with OSBPL1A. Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation. Interacts with OSBP. Interacts (via C-terminus) with RSAD2/viperin (via C- terminus). Interacts with HCV protein NS5A and NS5B. Interacts with IFITM3. TISSUE SPECIFICITY: Ubiquitous.|
|UniProt features for VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A|
CHAIN 1 249 Vesicle-associated membrane protein- associated protein A. |
DOMAIN 14 131 MSP.
COILED 169 205 Potential.
|Amino Acid Sequence for VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A|
|MASASGAMAK HEQILVLDPP TDLKFKGPFT DVVTTNLKLR NPSDRKVCFK VKTTAPRRYC VRPNSGIIDP GSTVTVSVML QPFDYDPNEK SKHKFMVQTI FAPPNTSDME AVWKEAKPDE LMDSKLRCVF EMPNENDKLN DMEPSKAVPL NASKQDGPMP KPHSVSLNDT ETRKLMEECK RLQGEMMKLS EENRHLRDEG LRLRKVAHSD KPGSTSTASF RDNVTSPLPS LLVVIAAIFI GFFLGKFIL|