VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A

VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A » VAMP-A; VAMP-associated protein A; VAP-A; 33 kDa VAMP-associated protein;VAP-33;
Hydrophobic Thickness 30.4 ± 1.4 Å
Tilt Angle 2 ± 1°
ΔGtransfer -44.9 kcal/mol
ΔGfold -15.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 227-247 (227-247)
Pathways

Tight junction (KEGG)

PDB 2rr3 (A=11-135)
OPM none
Complexes none
Interactions

1B42, Complex: 1B42:VAPA, PubMed

A4, Complex: VAPA:A4, PubMed

EGFR, Complex: VAPA:EGFR, PubMed

ERBB2, Complex: VAPA:ERBB2, PubMed

ESR1, Complex: VAPA:ESR1, PubMed

ITA4, Complex: ITA4:VAPA, PubMed

RMD3, Complex: RMD3:VAPA, PubMed

VAMP1, Complex: VAMP1:VAPA, PubMed

VAMP2, Complex: VAMP2:VAPA, PubMed

VAPB, Complex: VAPB:VAPA, PubMed

VCAM1, Complex: VCAM1:VAPA, PubMed

Domains

AA: 14-120, PDBID: 2RR3, Subunit A, Seq Identity:100%, MSP (Major sperm protein) domain

UniProt annotation for VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A
FUNCTION: May play a role in vesicle trafficking.

SUBUNIT: Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN. Interacts with OSBPL1A. Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation. Interacts with OSBP. Interacts (via C-terminus) with RSAD2/viperin (via C- terminus). Interacts with HCV protein NS5A and NS5B. Interacts with IFITM3.

TISSUE SPECIFICITY: Ubiquitous.

UniProt features for VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A
CHAIN 1 249 Vesicle-associated membrane protein- associated protein A.
DOMAIN 14 131 MSP.
COILED 169 205 Potential.
Amino Acid Sequence for VAPA_HUMAN » Vesicle-associated membrane protein-associated protein A
MASASGAMAK HEQILVLDPP TDLKFKGPFT DVVTTNLKLR NPSDRKVCFK VKTTAPRRYC VRPNSGIIDP GSTVTVSVML QPFDYDPNEK SKHKFMVQTI FAPPNTSDME AVWKEAKPDE LMDSKLRCVF EMPNENDKLN DMEPSKAVPL NASKQDGPMP KPHSVSLNDT ETRKLMEECK RLQGEMMKLS EENRHLRDEG LRLRKVAHSD KPGSTSTASF RDNVTSPLPS LLVVIAAIFI GFFLGKFIL