VAMP7_HUMAN » Vesicle-associated membrane protein 7

VAMP7_HUMAN » Vesicle-associated membrane protein 7
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VAMP7_HUMAN » Vesicle-associated membrane protein 7 » VAMP-7; Synaptobrevin-like protein 1;Tetanus-insensitive VAMP;Ti-VAMP;
Hydrophobic Thickness 25.6 ± 2.0 Å
Tilt Angle 0 ± 4°
ΔGtransfer -38.5 kcal/mol
ΔGfold -14.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 187-205 (187-206)
Pathways

Membrane Trafficking (Reactome)

SNARE interactions in vesicular transport (KEGG)

PDB 2dmw (1-118)
OPM none
Complexes none
Interactions

STX1A, Complex: STX1A:VAMP7, PubMed

STX3, Complex: VAMP7:STX3, PubMed

STX4, Complex: VAMP7:STX4, PubMed

STX6, Complex: STX6:VAMP7, PubMed

STX7, Complex: STX7:VAMP7, PubMed

STX8, Complex: STX8:VAMP7, PubMed

Domains

AA: 29-108, PDBID: 2DMW, Subunit A, Seq Identity:100%, Regulated-SNARE-like domain

AA: 122-210, PDBID: 4B93, Subunit A, Seq Identity:96%, Synaptobrevin

UniProt annotation for VAMP7_HUMAN » Vesicle-associated membrane protein 7
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

SUBUNIT: Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. May interact with STX17 (By similarity).

TISSUE SPECIFICITY: Detected in all tissues tested.

MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.

MISCELLANEOUS: Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release and target cell killing by natural killer cells.

UniProt features for VAMP7_HUMAN » Vesicle-associated membrane protein 7
CHAIN 2 220 Vesicle-associated membrane protein 7.
DOMAIN 7 110 Longin.
DOMAIN 125 185 v-SNARE coiled-coil homology.
Amino Acid Sequence for VAMP7_HUMAN » Vesicle-associated membrane protein 7
MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY LFHYICQDRI VYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY AMNSEFSSVL AAQLKHHSEN KGLDKVMETQ AQVDELKGIM VRNIDLVAQR GERLELLIDK TENLVDSSVT FKTTSRNLAR AMCMKNLKLT IIIIIVSIVF IYIIVSPLCG GFTWPSCVKK