VAMP4_HUMAN » Vesicle-associated membrane protein 4

VAMP4_HUMAN » Vesicle-associated membrane protein 4
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VAMP4_HUMAN » Vesicle-associated membrane protein 4 » VAMP-4;
Hydrophobic Thickness 31.2 ± 5.0 Å
Tilt Angle 27 ± 5°
ΔGtransfer -30.3 kcal/mol
ΔGfold -31.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 115-137 (111-140)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM 2nps (MOUSE)
Complexes

STX12:VAMP4:VTI1A:STX6_RAT

Interactions

B2L13, Complex: VAMP4:B2L13

KASH5, Complex: VAMP4:KASH5

STX12, Complex: STX12:VAMP4:VTI1A, PubMed

STX16, Complex: VAMP4:STX16, PubMed

STX4, Complex: STX4:VAMP4, PubMed

STX6, Complex: STX6:VAMP4:VTI1A, PDBID: 2nps

STX7, Complex: STX7:VAMP4, PubMed

STX8, Complex: STX8:VAMP4, PubMed

VTI1A, Complex: STX6:VAMP4:VTI1A, PDBID: 2nps

VTI1B, Complex: VTI1B:VAMP4, PubMed

Domains

AA: 49-137, PDBID: 2NPS, Subunit A, Seq Identity:96%, Synaptobrevin

UniProt annotation for VAMP4_HUMAN » Vesicle-associated membrane protein 4
FUNCTION: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

SUBUNIT: Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.

UniProt features for VAMP4_HUMAN » Vesicle-associated membrane protein 4
CHAIN 1 141 Vesicle-associated membrane protein 4.
DOMAIN 52 112 v-SNARE coiled-coil homology.
Amino Acid Sequence for VAMP4_HUMAN » Vesicle-associated membrane protein 4
MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW WRGCKIKAIM ALVAAILLLV IIILIVMKYR T