VAMP3_HUMAN » Vesicle-associated membrane protein 3

VAMP3_HUMAN » Vesicle-associated membrane protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
VAMP3_HUMAN » Vesicle-associated membrane protein 3 » VAMP-3; Cellubrevin;CEB; Synaptobrevin-3;
Hydrophobic Thickness 33.4 ± 2.2 Å
Tilt Angle 1 ± 2°
ΔGtransfer -27.7 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 76-98 (72-99)
Pathways

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

4F2, Complex: VAMP3:4F2, PubMed

A4, Complex: A4:VAMP3, PubMed

B2L13, Complex: VAMP3:B2L13

STX16, Complex: VAMP3:STX16, PubMed

STX2, Complex: STX2:VAMP3, PubMed

STX3, Complex: VAMP3:STX3, PubMed

STX4, Complex: STX4:VAMP3, PubMed

STX6, Complex: VAMP3:STX6, PubMed

STX7, Complex: STX7:VAMP3, PubMed

STX8, Complex: STX8:VAMP3, PubMed

VAMP2, Complex: VAMP2:VAMP3, PubMed

VAMP8, Complex: VAMP3:VAMP8, PubMed

VTI1A, Complex: VTI1A:VAMP3, PubMed

Domains

AA: 11-99, PDBID: 1KIL, Subunit A, Seq Identity:82%, Synaptobrevin

UniProt annotation for VAMP3_HUMAN » Vesicle-associated membrane protein 3
FUNCTION: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

SUBUNIT: Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.

UniProt features for VAMP3_HUMAN » Vesicle-associated membrane protein 3
CHAIN 2 100 Vesicle-associated membrane protein 3.
DOMAIN 14 74 v-SNARE coiled-coil homology.
Amino Acid Sequence for VAMP3_HUMAN » Vesicle-associated membrane protein 3
MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA DALQAGASQF ETSAAKLKRK YWWKNCKMWA IGITVLVIFI IIIIVWVVSS