VAMP2_HUMAN » Vesicle-associated membrane protein 2

VAMP2_HUMAN » Vesicle-associated membrane protein 2
Magnify VAMP2_HUMAN » Vesicle-associated membrane protein 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VAMP2_HUMAN » Vesicle-associated membrane protein 2 » VAMP-2; Synaptobrevin-2;
Hydrophobic Thickness 35.2 ± 4.6 Å
Tilt Angle 17 ± 0°
ΔGtransfer -29.3 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 89-114 (89-115)
Pathways

Insulin secretion (KEGG)

Membrane Trafficking (Reactome)

Neuronal System (Reactome)

Salivary secretion (KEGG)

SNARE interactions in vesicular transport (KEGG)

Synaptic vesicle cycle (KEGG)

Vasopressin-regulated water reabsorption (KEGG)

PDB 3rl0 (A/E...=28-60), 3rk2 (A/E=28-60), 3rk3 (A=28-60), 3fii (B=27-57), 3fie (C/D=22-57)
OPM 1kil (RAT), 2kog (RAT), 3hd7 (RAT)
Complexes

CPLX1:VAMP2:SNP25:STX1A_RAT

SNP25:VAMP2:STX1A_RAT

VAMP2:NSF:SNAA:STX1A_RAT

Interactions

SC22B, Complex: SC22B:VAMP2, PubMed

STX12, Complex: VAMP3:VAMP2:SNP25:STX12:SNAB, PubMed

STX1A, Complex: CPLX1:SNP25:STX1A:VAMP2, PDBID: 1kil

STX1B, Complex: STX1B:VAMP2, PubMed

STX2, Complex: STX2:VAMP2, PubMed

STX3, Complex: VAMP2:STX3, PubMed

STX4, Complex: SNAA:STX4:NSF:VAMP3:VAMP2, PubMed

SYT1, Complex: SYT1:SNP25:UN13B:VAMP2, PubMed

TIM50, Complex: VAMP2:TIM50, PubMed

TMEDA, Complex: VAMP2:TMEDA, PubMed

VAMP3, Complex: VAMP2:VAMP3, PubMed

VAMP8, Complex: VAMP8:VAMP2, PubMed

VAPA, Complex: VAMP2:VAPA, PubMed

VAPB, Complex: VAPB:VAMP2, PubMed

Domains

AA: 28-116, PDBID: 1KIL, Subunit A, Seq Identity:100%, Synaptobrevin

UniProt annotation for VAMP2_HUMAN » Vesicle-associated membrane protein 2
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane.

SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with BVES and STX4 (By similarity). Interacts with VAPA and VAPB.

TISSUE SPECIFICITY: Nervous system and skeletal muscle.

UniProt features for VAMP2_HUMAN » Vesicle-associated membrane protein 2
CHAIN 2 116 Vesicle-associated membrane protein 2.
DOMAIN 31 91 v-SNARE coiled-coil homology.
Amino Acid Sequence for VAMP2_HUMAN » Vesicle-associated membrane protein 2
MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IVYFSS