VAMP1_HUMAN » Vesicle-associated membrane protein 1

VAMP1_HUMAN » Vesicle-associated membrane protein 1
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
VAMP1_HUMAN » Vesicle-associated membrane protein 1 » VAMP-1; Synaptobrevin-1;
Hydrophobic Thickness 33.2 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -44.1 kcal/mol
ΔGfold -19.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 95-117 (91-118)
Pathways

Neuronal System (Reactome)

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

KASH5, Complex: VAMP1:KASH5

STX1A, Complex: STX1A:VAMP1, PubMed

STX1B, Complex: VAMP1:STX1B, PubMed

STX3, Complex: STX3:VAMP1, PubMed

STX4, Complex: VAMP1:STX4, PubMed

VAPA, Complex: VAMP1:VAPA, PubMed

VAPB, Complex: VAPB:VAMP1, PubMed

Domains

AA: 30-118, PDBID: 1KIL, Subunit A, Seq Identity:84%, Synaptobrevin

UniProt annotation for VAMP1_HUMAN » Vesicle-associated membrane protein 1
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane.

SUBUNIT: Interacts with VAPA and VAPB.

TISSUE SPECIFICITY: Nervous system, skeletal muscle and adipose tissue.

DISEASE: Spastic ataxia 1, autosomal dominant (SPAX1) OMIM: An autosomal dominant form of spastic ataxia, a progressive neurodegenerative disorder characterized by lower-limb spasticity and generalized ataxia with dysarthria, impaired ocular movements, and gait disturbance. Note=The disease is caused by mutations affecting the gene represented in this entry. A mutation affecting a critical donor site for the splicing of VAMP1 isoforms leads to the loss of neuron-specific isoform 1 and subsequently results in haploinsufficiency (PubMed). Therefore, there would be less neurotransmitter exocytosis in specific regions of the brain, causing the symptoms of SPAX1.

UniProt features for VAMP1_HUMAN » Vesicle-associated membrane protein 1
CHAIN 1 118 Vesicle-associated membrane protein 1.
DOMAIN 33 93 v-SNARE coiled-coil homology.
Amino Acid Sequence for VAMP1_HUMAN » Vesicle-associated membrane protein 1
MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFT