VAM7B_DICDI » Vesicle-associated membrane protein 7B

VAM7B_DICDI » Vesicle-associated membrane protein 7B
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
VAM7B_DICDI » Vesicle-associated membrane protein 7B »
Hydrophobic Thickness 31.2 ± 3.2 Å
Tilt Angle 35 ± 3°
ΔGtransfer -28.8 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 183-208 (183-209)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 29-108, PDBID: 2VX8, Subunit A, Seq Identity:47%, Regulated-SNARE-like domain

AA: 122-211, PDBID: 5BV0, Subunit C, Seq Identity:42%, Synaptobrevin

UniProt annotation for VAM7B_DICDI » Vesicle-associated membrane protein 7B
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion (By similarity).
UniProt features for VAM7B_DICDI » Vesicle-associated membrane protein 7B
CHAIN 1 260 Vesicle-associated membrane protein 7B.
DOMAIN 7 110 Longin.
DOMAIN 125 186 v-SNARE coiled-coil homology.
Amino Acid Sequence for VAM7B_DICDI » Vesicle-associated membrane protein 7B
MPIIYSLVAR GSSVLAEFTS TNGNFVTITR RILDLIPPND TKMSYVYEKY IFHYLVSDTL TYLCMADEEF GRRIPFTFLD DVKNRFKSMY GDKGKTAIAY GMNSDFSRTL ENLMDHYSNT TRVDTMSRTM AEIDEVKNIL VSDIAPQLLK RGEKIEMLVE RTDTLNQQSF KFKKQSKQLK CAMWWKNVKL MLVLGAIVLI IIFIIVMSYC DGFRSGSKCR SSPSSNSTPT PTPTETPTPT PTPTSTPTPS QLLETLLNQF