VAM7A_DICDI » Vesicle-associated membrane protein 7A

VAM7A_DICDI » Vesicle-associated membrane protein 7A
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
VAM7A_DICDI » Vesicle-associated membrane protein 7A »
Hydrophobic Thickness 34.8 ± 4.4 Å
Tilt Angle 28 ± 4°
ΔGtransfer -26.9 kcal/mol
ΔGfold -24.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 188-213 (185-216)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

STX7A, Complex: STX7A:VAM7A, PubMed

Domains

AA: 32-108, PDBID: 2DMW, Subunit A, Seq Identity:27%, Regulated-SNARE-like domain

AA: 123-211, PDBID: 5BV0, Subunit C, Seq Identity:36%, Synaptobrevin

UniProt annotation for VAM7A_DICDI » Vesicle-associated membrane protein 7A
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis.

SUBUNIT: Component of the SNARE complex composed of syn7A, syn8A, vamp7A and vti1A.

UniProt features for VAM7A_DICDI » Vesicle-associated membrane protein 7A
CHAIN 1 216 Vesicle-associated membrane protein 7A.
DOMAIN 6 112 Longin.
DOMAIN 126 186 v-SNARE coiled-coil homology.
Amino Acid Sequence for VAM7A_DICDI » Vesicle-associated membrane protein 7A
MSQTDILYAC VSYKGVCLVE HKIANGNFID LARRLITKIP PTSKKIYTSE NHNFHYISEN DLAFLCLCHE KLGVQIPSEF LSDIRQQFIR SYGQSFSQNS PTATYDPFIR VLEERMKYYS NPKSNKMNLV MDQVSEAKGA LTDAIEKTIH RGEKIEIIVD KTERLQSESF VFKSNSVALK RKLWWQNKKL AIAIGLVVCI LIAVITLALL KYFKVI