VAM3_YEAST » Syntaxin VAM3

VAM3_YEAST » Syntaxin VAM3
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Topology in Vacuolar membrane
Topologyvacuole lumenal side
cytoplasmic side
VAM3_YEAST » Syntaxin VAM3 » Vacuolar morphogenesis protein 3;
Hydrophobic Thickness 32.2 ± 2.5 Å
Tilt Angle 2 ± 1°
ΔGtransfer -24.7 kcal/mol
ΔGfold -16.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 261-282 (252-282)
Pathways

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB 1hs7 (23-119)
OPM none
Complexes none
Interactions

ANP1, Complex: VAM3:ANP1

CBP4, Complex: VAM3:CBP4

GDA1, Complex: GDA1:VAM3

GEM1, Complex: VAM3:GEM1

GOSR1, Complex: VAM3:GOSR1

HOC1, Complex: VAM3:HOC1

MMM1, Complex: VAM3:MMM1

MNN11, Complex: MNN11:VAM3

MTC6, Complex: VAM3:MTC6

NYV1, Complex: VAM3:NYV1, PubMed

OST1, Complex: VAM3:OST1

PEP12, Complex: PEP12:VAM3

PSD1, Complex: PSD1:VAM3

QCR8, Complex: QCR8:VAM3

SC6B1, Complex: SC6B1:VAM3

SEC22, Complex: SEC22:VAM3, PubMed

SFT1, Complex: VAM3:SFT1, PubMed

SNC1, Complex: VAM3:SNC1

SNC2, Complex: VAM3:SNC2

SSO2, Complex: SSO2:VAM3, PubMed

STX8, Complex: STX8:VAM3, PubMed

TLG1, Complex: TLG1:VAM3, PubMed

VPS10, Complex: VAM3:VPS10

VPS70, Complex: VAM3:VPS70

VTI1, Complex: VTI1:VAM3, PubMed

YHO0, Complex: YHO0:VAM3, PubMed

Domains

AA: 30-117, PDBID: 1HS7, Subunit A, Seq Identity:100%, Syntaxin-like protein

AA: 226-278, PDBID: 1GL2, Subunit B, Seq Identity:26%, SNARE domain

UniProt annotation for VAM3_YEAST » Syntaxin VAM3
FUNCTION: Required for vacuolar assembly. Provides the t-SNARE function in a late step of the vacuolar assembly. Required for homotypic vacuole membrane fusion, autophagy and fusion of biosynthetic transport vesicles with the vacuole. Required for the delivery of alpha-factor receptor-ligand complexes to the vacuole.

SUBUNIT: Associates with VAM7.

MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.

UniProt features for VAM3_YEAST » Syntaxin VAM3
CHAIN 1 283 Syntaxin VAM3.
DOMAIN 190 252 t-SNARE coiled-coil homology.
COILED 28 48 Potential.
COILED 84 111 Potential.
COILED 169 189 Potential.
Amino Acid Sequence for VAM3_YEAST » Syntaxin VAM3
MSFFDIEAQS SKGNSQQEPQ FSTNQKTKEL SNLIETFAEQ SRVLEKECTK IGSKRDSKEL RYKIETELIP NCTSVRDKIE SNILIHQNGK LSADFKNLKT KYQSLQQSYN QRKSLFPLKT PISPGTSKER KDIHPRTEAV RQDPESSYIS IKVNEQSPLL HNEGQHQLQL QEEQEQQQQG LSQEELDFQT IIHQERSQQI GRIHTAVQEV NAIFHQLGSL VKEQGEQVTT IDENISHLHD NMQNANKQLT RADQHQRDRN KCGKVTLIII IVVCMVVLLA VLS