UROL1_HUMAN » Uromodulin-like 1

UROL1_HUMAN » Uromodulin-like 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UROL1_HUMAN » Uromodulin-like 1 » Olfactorin;
Hydrophobic Thickness 34.8 ± 5.4 Å
Tilt Angle 30 ± 0°
ΔGtransfer -28.2 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1267-1295 (1264-1298)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 117-157, PDBID: 1FLE, Subunit I, Seq Identity:40%, WAP-type (Whey Acidic Protein) 'four-disulfide core'

AA: 264-301, PDBID: 2KL7, Subunit A, Seq Identity:52%, Calcium-binding EGF domain

AA: 398-478, PDBID: 2ACM, Subunit A, Seq Identity:29%, SEA domain

AA: 507-551, PDBID: 1TOZ, Subunit A, Seq Identity:42%, Calcium-binding EGF domain

AA: 897-941, PDBID: 1TOZ, Subunit A, Seq Identity:44%, Calcium-binding EGF domain

AA: 993-1233, PDBID: 4WRN, Subunit A, Seq Identity:26%, Zona pellucida-like domain

UniProt annotation for UROL1_HUMAN » Uromodulin-like 1
TISSUE SPECIFICITY: Isoform 4 is expressed at low level in kidney, testis and fetal thymus. Isoform 3 is expressed at low level in prostate, testis and fetal thymus.
UniProt features for UROL1_HUMAN » Uromodulin-like 1
SIGNAL 1 21 Potential.
CHAIN 22 1318 Uromodulin-like 1.
DOMAIN 33 106 EMI.
DOMAIN 114 158 WAP.
DOMAIN 264 313 EGF-like 1; calcium-binding (Potential).
DOMAIN 313 395 Fibronectin type-III 1.
DOMAIN 395 506 SEA 1.
DOMAIN 507 552 EGF-like 2; calcium-binding (Potential).
DOMAIN 703 787 Fibronectin type-III 2.
DOMAIN 787 890 SEA 2.
DOMAIN 897 938 EGF-like 3; calcium-binding (Potential).
DOMAIN 992 1235 ZP.
DISULFID 37 94 Potential.
DISULFID 61 70 Potential.
DISULFID 93 104 Potential.
DISULFID 511 525 By similarity.
DISULFID 519 534 By similarity.
DISULFID 536 551 By similarity.
DISULFID 901 914 By similarity.
DISULFID 908 923 By similarity.
DISULFID 1157 1215 By similarity.
Amino Acid Sequence for UROL1_HUMAN » Uromodulin-like 1
MLRTSGLALL ALVSAVGPSQ ASGFTEKGLS LLGYQLCSHR VTHTVQKVEA VQTSYTSYVS CGGWIPWRRC PKMVYRTQYL VVEVPESRNV TDCCEGYEQL GLYCVLPLNQ SGQFTSRPGA CPAEGPEPST SPCSLDIDCP GLEKCCPWSG GRYCMAPAPQ APERDPVGSW YNVTILVKMD FKELQQVDPR LLNHMRLLHS LVTSALQPMA STVHHLHSAP GNASTTVSRL LLGLPRPLPV ADVSTLLGDI AKRVYEVISV QVQDVNECFY EELNACSGRE LCANLEGSYW CVCHQEAPAT SPRKLNLEWE DCPPVSDYVV LNVTSDSFQV SWRLNSTQNH TFHVRVYRGM ELLRSARTQS QALAVAGLEA GVLYRVKTSY QGCGADVSTT LTIKTNAQVF EVTIKIVNHN LTEKLLNRSS VEYQDFSRQL LHEVESSFPP VVSDLYRSGK LRMQIVSLQA GSVVVRLKLT VQDPGFPMGI STLAPILQPL LASTVFQIDR QGTRVQDWDE CVDSAEHDCS PAAWCINLEG SYTCQCRTTR DATPSRAGRA CEGDLVSPMG GGLSAATGVT VPGLGTGTAA LGLENFTLSP SPGYPQGTPA AGQAWTPEPS PRRGGSNVVG YDRNNTGKGV EQELQGNSIM EPPSWPSPTE DPTGHFLWHA TRSTRETLLN PTWLRNEDSG PSGSVDLPLT STLTALKTPA CVPVSIGRIM VSNVTSTGFH LAWEADLAMD STFQLTLTSM WSPAVVLETW NTSVTLSGLE PGVLHLVEIM AKACGKEGAR AHLKVRTAAR KLIGKVRIKN VRYSESFRNA SSQEYRDFLE LFFRMVRGSL PATMCQHMDA GGVRMEVVSV TNGSIVVEFH LLIIADVDVQ EVSAAFLTAF QTVPLLEVIR GDTFIQDYDE CERKEDDCVP GTSCRNTLGS FTCSCEGGAP DFPVEYSERP CEGDSPGNET WATSPERPLT TAGTKAAFVQ GTSPTPQGLP QRLNLTGAVR VLCEIEKVVV AIQKRFLQQE SIPESSLYLS HPSCNVSHSN GTHVLLEAGW SECGTLMQSN MTNTVVRTTL RNDLSQEGII HHLKILSPIY CAFQNDLLTS SGFTLEWGVY TIIEDLHGAG NFVTEMQLFI GDSPIPQNYS VSASDDVRIE VGLYRQKSNL KVVLTECWAT PSSNARDPIT FSFINNSCPV PNTYTNVIEN GNSNKAQFKL RIFSFINDSI VYLHCKLRVC MESPGATCKI NCNNFRLLQN SETSATHQMS WGPLIRSEGE PPHAEAGLGA GYVVLIVVAI FVLVAGTATL LIVRYQRMNG RYNFKIQSNN FSYQVFYE