UPK3A_HUMAN » Uroplakin-3a

UPK3A_HUMAN » Uroplakin-3a
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UPK3A_HUMAN » Uroplakin-3a » UP3a; Uroplakin III;UPIII;
Hydrophobic Thickness 33.2 ± 4.2 Å
Tilt Angle 41 ± 0°
ΔGtransfer -27.8 kcal/mol
ΔGfold -15.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 208-237 (208-240)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for UPK3A_HUMAN » Uroplakin-3a
FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

SUBUNIT: Heterodimer with uroplakin-1B (UPK1B).

TISSUE SPECIFICITY: Expressed in ureter.

DISEASE: Note=Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.

UniProt features for UPK3A_HUMAN » Uroplakin-3a
SIGNAL 1 18 By similarity.
CHAIN 19 287 Uroplakin-3a.
Amino Acid Sequence for UPK3A_HUMAN » Uroplakin-3a
MPPLWALLAL GCLRFGSAVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD SKEALTGTHE VYLYVLVDSA ISRNASVQDS TNTPLGSTFL QTEGGRTGPY KAVAFDLIPC SDLPSLDAIG DVSKASQILN AYLVRVGANG TCLWDPNFQG LCNAPLSAAT EYRFKYVLVN MSTGLVEDQT LWSDPIRTNQ LTPYSTIDTW PGRRSGGMIV ITSILGSLPF FLLVGFAGAI ALSLVDMGSS DGETTHDSQI TQEAVPKSLG ASESSYTSVN RGPPLDRAEV YSSKLQD