UPK2_HUMAN » Uroplakin-2

UPK2_HUMAN » Uroplakin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UPK2_HUMAN » Uroplakin-2 » UP2; Uroplakin II;UPII;
Hydrophobic Thickness 34.4 ± 3.6 Å
Tilt Angle 21 ± 6°
ΔGtransfer -30.6 kcal/mol
ΔGfold -25.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 156-180 (156-183)
Pathways none
PDB none
OPM none
Complexes none
Interactions

KASH5, Complex: UPK2:KASH5

Domains

AA: 6-184, Uroplakin II

UniProt annotation for UPK2_HUMAN » Uroplakin-2
FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).

SUBUNIT: Interacts with uroplakin-1a (UPK1A).

TISSUE SPECIFICITY: Expressed in ureter.

UniProt features for UPK2_HUMAN » Uroplakin-2
SIGNAL 1 25 Potential.
PROPEP 26 84 By similarity.
CHAIN 85 184 Uroplakin-2.
Amino Acid Sequence for UPK2_HUMAN » Uroplakin-2
MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL GSRK