UNC5D_HUMAN » Netrin receptor UNC5D

UNC5D_HUMAN » Netrin receptor UNC5D
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UNC5D_HUMAN » Netrin receptor UNC5D » Protein unc-5 homolog 4;Protein unc-5 homolog D;
Hydrophobic Thickness 34.8 ± 2.8 Å
Tilt Angle 2 ± 2°
ΔGtransfer -23.2 kcal/mol
ΔGfold -20.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 381-404 (377-407)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 159-249, PDBID: 4V2A, Subunit A, Seq Identity:57%, Immunoglobulin I-set domain

AA: 256-306, PDBID: 3OJY, Subunit A, Seq Identity:48%, Thrombospondin type 1 domain

AA: 312-359, PDBID: 1LSL, Subunit A, Seq Identity:40%, Thrombospondin type 1 domain

AA: 543-639, PDBID: 3G5B, Subunit A, Seq Identity:47%, ZU5 domain

AA: 687-826, PDBID: 3G5B, Subunit A, Seq Identity:46%, UPA domain

AA: 858-936, PDBID: 1WMG, Subunit B, Seq Identity:60%, Death domain

UniProt annotation for UNC5D_HUMAN » Netrin receptor UNC5D
FUNCTION: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

SUBUNIT: Interacts with the cytoplasmic part of DCC.

UniProt features for UNC5D_HUMAN » Netrin receptor UNC5D
SIGNAL 1 32 Potential.
CHAIN 33 953 Netrin receptor UNC5D.
DOMAIN 54 151 Ig-like.
DOMAIN 153 244 Ig-like C2-type.
DOMAIN 252 306 TSP type-1 1.
DOMAIN 308 360 TSP type-1 2.
DOMAIN 540 645 ZU5.
DOMAIN 859 936 Death.
REGION 703 721 Interaction with DCC (By similarity).
SITE 416 417 Cleavage; by caspase-3 (By similarity).
DISULFID 75 134 By similarity.
DISULFID 180 231 By similarity.
DISULFID 264 301 By similarity.
DISULFID 268 305 By similarity.
DISULFID 279 291 By similarity.
Amino Acid Sequence for UNC5D_HUMAN » Netrin receptor UNC5D
MGRAAATAGG GGGARRWLPW LGLCFWAAGT AAARGTDNGE ALPESIPSAP GTLPHFIEEP DDAYIIKSNP IALRCKARPA MQIFFKCNGE WVHQNEHVSE ETLDESSGLK VREVFINVTR QQVEDFHGPE DYWCQCVAWS HLGTSKSRKA SVRIAYLRKN FEQDPQGREV PIEGMIVLHC RPPEGVPAAE VEWLKNEEPI DSEQDENIDT RADHNLIIRQ ARLSDSGNYT CMAANIVAKR RSLSATVVVY VNGGWSSWTE WSACNVRCGR GWQKRSRTCT NPAPLNGGAF CEGMSVQKIT CTSLCPVDGS WEVWSEWSVC SPECEHLRIR ECTAPPPRNG GKFCEGLSQE SENCTDGLCI LDKKPLHEIK PQSIENASDI ALYSGLGAAV VAVAVLVIGV TLYRRSQSDY GVDVIDSSAL TGGFQTFNFK TVRQGNSLLL NSAMQPDLTV SRTYSGPICL QDPLDKELMT ESSLFNPLSD IKVKVQSSFM VSLGVSERAE YHGKNHSRTF PHGNNHSFST MHPRNKMPYI QNLSSLPTRT ELRTTGVFGH LGGRLVMPNT GVSLLIPHGA IPEENSWEIY MSINQGEPSL QSDGSEVLLS PEVTCGPPDM IVTTPFALTI PHCADVSSEH WNIHLKKRTQ QGKWEEVMSV EDESTSCYCL LDPFACHVLL DSFGTYALTG EPITDCAVKQ LKVAVFGCMS CNSLDYNLRV YCVDNTPCAF QEVVSDERHQ GGQLLEEPKL LHFKGNTFSL QISVLDIPPF LWRIKPFTAC QEVPFSRVWC SNRQPLHCAF SLERYTPTTT QLSCKICIRQ LKGHEQILQV QTSILESERE TITFFAQEDS TFPAQTGPKA FKIPYSIRQR ICATFDTPNA KGKDWQMLAQ KNSINRNLSY FATQSSPSAV ILNLWEARHQ HDGDLDSLAC ALEEIGRTHT KLSNISESQL DEADFNYSRQ NGL