UNC5C_HUMAN » Netrin receptor UNC5C

UNC5C_HUMAN » Netrin receptor UNC5C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UNC5C_HUMAN » Netrin receptor UNC5C » Protein unc-5 homolog 3;Protein unc-5 homolog C;
Hydrophobic Thickness 37.6 ± 1.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -52.8 kcal/mol
ΔGfold -26.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 377-402 (374-406)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 167-257, PDBID: 4V2A, Subunit A, Seq Identity:65%, Immunoglobulin I-set domain

AA: 264-313, PDBID: 3OJY, Subunit A, Seq Identity:50%, Thrombospondin type 1 domain

AA: 317-367, PDBID: 3OJY, Subunit A, Seq Identity:46%, Thrombospondin type 1 domain

AA: 531-628, PDBID: 3G5B, Subunit A, Seq Identity:50%, ZU5 domain

AA: 678-817, PDBID: 3G5B, Subunit A, Seq Identity:72%, UPA domain

AA: 849-928, PDBID: 1WMG, Subunit B, Seq Identity:66%, Death domain

UniProt annotation for UNC5C_HUMAN » Netrin receptor UNC5C
FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

SUBUNIT: Interacts with the cytoplasmic part of DCC.

TISSUE SPECIFICITY: Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung.

MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

UniProt features for UNC5C_HUMAN » Netrin receptor UNC5C
SIGNAL 1 40 Potential.
CHAIN 41 931 Netrin receptor UNC5C.
DOMAIN 62 159 Ig-like.
DOMAIN 161 256 Ig-like C2-type.
DOMAIN 260 314 TSP type-1 1.
DOMAIN 316 368 TSP type-1 2.
DOMAIN 528 634 ZU5.
DOMAIN 850 929 Death.
REGION 694 712 Interaction with DCC (By similarity).
SITE 415 416 Cleavage; by caspase-3 (By similarity).
DISULFID 83 142 By similarity.
DISULFID 188 239 By similarity.
DISULFID 272 309 By similarity.
DISULFID 276 313 By similarity.
DISULFID 287 299 By similarity.
Amino Acid Sequence for UNC5C_HUMAN » Netrin receptor UNC5C
MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL LTRPVVLTMH HCADPNTEDW KILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ MGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA NTITTVTGPS AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y