UNC5B_HUMAN » Netrin receptor UNC5B

UNC5B_HUMAN » Netrin receptor UNC5B
Magnify UNC5B_HUMAN » Netrin receptor UNC5BEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UNC5B_HUMAN » Netrin receptor UNC5B » Protein unc-5 homolog 2;Protein unc-5 homolog B;p53-regulated receptor for death and life protein 1;
Hydrophobic Thickness 36.0 ± 2.6 Å
Tilt Angle 0 ± 5°
ΔGtransfer -45.9 kcal/mol
ΔGfold -26.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 376-399 (373-403)
Pathways

Apoptosis (Reactome)

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB none
OPM 3g5b (RAT)
Complexes

UNC5B:UNC5B_MOUSE

Interactions

NEO1, Complex: NEO1:UNC5B, PubMed

UNC5B, Complex: Homodimer of netrin receptor UNC5B, PDBID: 1WMG

Domains

AA: 153-243, PDBID: 4V2A, Subunit A, Seq Identity:66%, Immunoglobulin I-set domain

AA: 250-299, PDBID: 3OJY, Subunit A, Seq Identity:51%, Thrombospondin type 1 domain

AA: 306-353, PDBID: 1LSL, Subunit A, Seq Identity:39%, Thrombospondin type 1 domain

AA: 544-641, PDBID: 3G5B, Subunit A, Seq Identity:90%, ZU5 domain

AA: 691-830, PDBID: 3G5B, Subunit A, Seq Identity:93%, UPA domain

AA: 863-941, PDBID: 3G5B, Subunit A, Seq Identity:92%, Death domain

UniProt annotation for UNC5B_HUMAN » Netrin receptor UNC5B
FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

SUBUNIT: Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain).

TISSUE SPECIFICITY: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.

INDUCTION: By p53/TP53.

MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

UniProt features for UNC5B_HUMAN » Netrin receptor UNC5B
SIGNAL 1 26 Potential.
CHAIN 27 945 Netrin receptor UNC5B.
DOMAIN 48 145 Ig-like.
DOMAIN 147 242 Ig-like C2-type.
DOMAIN 246 300 TSP type-1 1.
DOMAIN 302 354 TSP type-1 2.
DOMAIN 544 688 ZU5.
DOMAIN 865 943 Death.
REGION 689 838 UPA domain (By similarity).
REGION 707 725 Interaction with DCC (By similarity).
SITE 412 413 Cleavage; by caspase-3.
DISULFID 69 128 By similarity.
DISULFID 174 225 By similarity.
DISULFID 258 295 By similarity.
DISULFID 262 299 By similarity.
DISULFID 273 285 By similarity.
Amino Acid Sequence for UNC5B_HUMAN » Netrin receptor UNC5B
MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF LQEPQDAYIV KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA TGLRVREVQI EVSRQQVEEL FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV PVAEVEWLKN EDVIDPTQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCMQNKKTL SDPNSHLLEA SGDAALYAGL VVAIFVVVAI LMAVGVVVYR RNCRDFDTDI TDSSAALTGG FHPVNFKTAR PSNPQLLHPS VPPDLTASAG IYRGPVYALQ DSTDKIPMTN SPLLDPLPSL KVKVYSSSTT GSGPGLADGA DLLGVLPPGT YPSDFARDTH FLHLRSASLG SQQLLGLPRD PGSSVSGTFG CLGGRLSIPG TGVSLLVPNG AIPQGKFYEM YLLINKAEST LPLSEGTQTV LSPSVTCGPT GLLLCRPVIL TMPHCAEVSA RDWIFQLKTQ AHQGHWEEVV TLDEETLNTP CYCQLEPRAC HILLDQLGTY VFTGESYSRS AVKRLQLAVF APALCTSLEY SLRVYCLEDT PVALKEVLEL ERTLGGYLVE EPKPLMFKDS YHNLRLSLHD LPHAHWRSKL LAKYQEIPFY HIWSGSQKAL HCTFTLERHS LASTELTCKI CVRQVEGEGQ IFQLHTTLAE TPAGSLDTLC SAPGSTVTTQ LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RMLAQKLSMD RYLNYFATKA SPTGVILDLW EALQQDDGDL NSLASALEEM GKSEMLVAVA TDGDC