UNC5A_HUMAN » Netrin receptor UNC5A

UNC5A_HUMAN » Netrin receptor UNC5A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UNC5A_HUMAN » Netrin receptor UNC5A » Protein unc-5 homolog 1;Protein unc-5 homolog A;
Hydrophobic Thickness 38.0 ± 3.6 Å
Tilt Angle 2 ± 2°
ΔGtransfer -31.8 kcal/mol
ΔGfold -29.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 303-328 (300-332)
Pathways

Apoptosis (Reactome)

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB 4v2a (1-303)
OPM none
Complexes none
Interactions none
Domains

AA: 149-239, PDBID: 4V2A, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 442-539, PDBID: 3G5B, Subunit A, Seq Identity:51%, ZU5 domain

AA: 589-728, PDBID: 3G5B, Subunit A, Seq Identity:61%, UPA domain

AA: 760-834, PDBID: 1WMG, Subunit B, Seq Identity:57%, Death domain

UniProt annotation for UNC5A_HUMAN » Netrin receptor UNC5A
FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

SUBUNIT: Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity).

INDUCTION: By p53/TP53.

DOMAIN: The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.

MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

UniProt features for UNC5A_HUMAN » Netrin receptor UNC5A
SIGNAL 1 25 Potential.
CHAIN 26 842 Netrin receptor UNC5A.
DOMAIN 44 141 Ig-like.
DOMAIN 155 234 Ig-like C2-type.
DOMAIN 242 294 TSP type-1.
DOMAIN 439 545 ZU5.
DOMAIN 761 841 Death.
REGION 605 623 Interaction with DCC (By similarity).
SITE 340 341 Cleavage; by caspase-3 (By similarity).
DISULFID 65 124 By similarity.
DISULFID 170 221 By similarity.
Amino Acid Sequence for UNC5A_HUMAN » Netrin receptor UNC5A
MAVRPGLWPA LLGIVLAAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP EDVYIVKNKP VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSNGLP TMEVRINVSR QQVEKVFGLE EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE VEWLRNEDLV DPSLDPNVYI TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY VDGSWSPWSK WSACGLDCTH WRSRECSDPA PRNGGEECQG TDLDTRNCTS DLCVHTASGP EDVALYVGLI AVAVCLVLLL LVLILVYCRK KEGLDSDVAD SSILTSGFQP VSIKPSKADN PHLLTIQPDL STTTTTYQGS LCPRQDGPSP KFQLTNGHLL SPLGGGRHTL HHSSPTSEAE EFVSRLSTQN YFRSLPRGTS NMTYGTFNFL GGRLMIPNTG ISLLIPPDAI PRGKIYEIYL TLHKPEDVRL PLAGCQTLLS PIVSCGPPGV LLTRPVILAM DHCGEPSPDS WSLRLKKQSC EGSWEDVLHL GEEAPSHLYY CQLEASACYV FTEQLGRFAL VGEALSVAAA KRLKLLLFAP VACTSLEYNI RVYCLHDTHD ALKEVVQLEK QLGGQLIQEP RVLHFKDSYH NLRLSIHDVP SSLWKSKLLV SYQEIPFYHI WNGTQRYLHC TFTLERVSPS TSDLACKLWV WQVEGDGQSF SINFNITKDT RFAELLALES EAGVPALVGP SAFKIPFLIR QKIISSLDPP CRRGADWRTL AQKLHLDSHL SFFASKPSPT AMILNLWEAR HFPNGNLSQL AAAVAGLGQP DAGLFTVSEA EC