UN5CL_HUMAN » UNC5C-like protein

UN5CL_HUMAN » UNC5C-like protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
UN5CL_HUMAN » UNC5C-like protein » Protein unc-5 homolog C-like;ZU5 and death domain-containing protein;
Hydrophobic Thickness 34.4 ± 2.6 Å
Tilt Angle 19 ± 2°
ΔGtransfer -20.0 kcal/mol
ΔGfold -9.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 10-34 (10-34)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 103-196, PDBID: 2KXR, Subunit A, Seq Identity:38%, ZU5 domain

AA: 243-370, PDBID: 3G5B, Subunit A, Seq Identity:19%, UPA domain

AA: 413-491, PDBID: 2DBF, Subunit A, Seq Identity:31%, Death domain

UniProt annotation for UN5CL_HUMAN » UNC5C-like protein
FUNCTION: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.

SUBUNIT: Interacts with p65/RELA and NFKB1.

TISSUE SPECIFICITY: Expressed in pancreas, liver and kidney.

UniProt features for UN5CL_HUMAN » UNC5C-like protein
CHAIN 1 518 UNC5C-like protein.
DOMAIN 100 207 ZU5.
DOMAIN 415 494 Death.
REGION 186 400 Interaction with RELA and NFKB1.
Amino Acid Sequence for UN5CL_HUMAN » UNC5C-like protein
MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL GACWTLNGQE EPVSQPTPQL ENEVSRQHLP ATLPEMVAFY QELHTPTQGQ TMVRQLMHKL LVFSAREVDH RGGCLMLQDT GISLLIPPGA VAVGRQERVS LILVWDLSDA PSLSQAQGLV SPVVACGPHG ASFLKPCTLT FKHCAEQPSH ARTYSSNTTL LDAKVWRPLG RPGAHASRDE CRIHLSHFSL YTCVLEAPVG REARKWLQLA VFCSPLVPGQ SHLQLRIYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF NGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKA ADENEDCSAL TNEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS QPPPCNRLPP ELFEQLRMLL EPNSITGNDW RRLASHLGLC GMKIRFLSCQ RSPAAAILEL FEEQNGSLQE LHYLMTVMER LDCASAIQNY LSGTHGGSPG PERGGARDNQ GLELDEKL