TYRO3_HUMAN » Tyrosine-protein kinase receptor TYRO3

TYRO3_HUMAN » Tyrosine-protein kinase receptor TYRO3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
TYRO3_HUMAN » Tyrosine-protein kinase receptor TYRO3 » Tyrosine-protein kinase BYK;Tyrosine-protein kinase DTK;Tyrosine-protein kinase RSE;Tyrosine-protein kinase SKY;Tyrosine-protein kinase TIF;
Hydrophobic Thickness 32.8 ± 1.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -38.9 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 429-453 (429-457)
Pathways none
PDB 1rhf (41-222)
OPM none
Complexes none
Interactions

UFO, Complex: TYRO3:UFO

Domains

AA: 44-135, PDBID: 1RHF, Subunit B, Seq Identity:100%, Immunoglobulin I-set domain

AA: 226-310, PDBID: 2EE2, Subunit A, Seq Identity:27%, Fibronectin type III domain

AA: 324-406, PDBID: 2EDY, Subunit A, Seq Identity:30%, Fibronectin type III domain

AA: 518-786, PDBID: 3QUP, Subunit A, Seq Identity:100%, Protein tyrosine kinase

UniProt annotation for TYRO3_HUMAN » Tyrosine-protein kinase receptor TYRO3
FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

SUBUNIT: Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 (By similarity). Interacts with PIK3R1; this interaction increases PI3-kinase activity (By similarity).

TISSUE SPECIFICITY: Abundant in the brain and lower levels in other tissues.

UniProt features for TYRO3_HUMAN » Tyrosine-protein kinase receptor TYRO3
SIGNAL 1 40 Potential.
CHAIN 41 890 Tyrosine-protein kinase receptor TYRO3.
DOMAIN 41 128 Ig-like C2-type 1.
DOMAIN 139 220 Ig-like C2-type 2.
DOMAIN 225 317 Fibronectin type-III 1.
DOMAIN 322 413 Fibronectin type-III 2.
DOMAIN 518 790 Protein kinase.
ACT_SITE 655 655 Proton acceptor (By similarity).
DISULFID 64 117
DISULFID 160 203
Amino Acid Sequence for TYRO3_HUMAN » Tyrosine-protein kinase receptor TYRO3
MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC